Preparation of collagen-polysaccharide composite hydrogels and research progress in biomedical applications_Journal of Biomedical Engineering

Authors：

XU Meihong ¹ ,  JIAO Enxiang ^1,2,3 , SUN Ziru ¹ , YUAN Kunshan ² , FENG Xiangyi ¹ , LIU Yuanbiao ^1,2 , GUO Kai ^1,2 , LI Kun ^1,2 ,  ZHANG Haijun ^1,2,3 , ZHANG Xuehai ¹

1. College of Materials Science and Engineering, Shandong University of Technology, Zibo, Shandong 255000, P. R. China;
2. National Local Joint Engineering Laboratory of Biomedical Material Modification Technology, Dezhou, Shandong 253000, P. R. China;
3. School of Medicine, Tongji University, Shanghai 200000, P. R. China;

Corresponding author：

JIAO Enxiang, Email: jiaoex@sdut.edu.cn

Keywords：

Collagen; Polysaccharide; Hydrogels; Biomedicine

DOI：

10.7507/1001-5515.202407008

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Collagen contains abundant cell binding motifs, which are conducive to adhesion, migration, and differentiation, maintain cell vitality and promote cell proliferation. However, pure collagen hydrogel has some shortcomings such as poor mechanical properties, poor thermal stability and fast degradation. Numerous studies have shown that the properties of collagen can be improved by combining it with natural polysaccharides such as alginate, chitosan, hyaluronic acid and cellulose. In this paper, the research status and biological application fields of four kinds of composite hydrogels, including collagen-alginate composite hydrogels, collagen-chitosan hydrogels, collagen-hyaluronic acid hydrogels and collagen-cellulose hydrogels, were summarized. The common preparation methods of four kinds of composite hydrogels were introduced, and the future development direction of collagen-based composite hydrogels was prospected.

Citation： XU Meihong, JIAO Enxiang, SUN Ziru, YUAN Kunshan, FENG Xiangyi, LIU Yuanbiao, GUO Kai, LI Kun, ZHANG Haijun, ZHANG Xuehai. Preparation of collagen-polysaccharide composite hydrogels and research progress in biomedical applications. Journal of Biomedical Engineering, 2024, 41(6): 1286-1292. doi: 10.7507/1001-5515.202407008 Copy

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