Research on a portable electrical impedance tomography system for evaluating blood compatibility of biomaterials_Journal of Biomedical Engineering

Authors：

PENG Piao ^1,2 , CHEN Huaihao ² , CHE Bo ² , LI Xuan ² , FAN Chunjian ² , LIU Lei ^2,3 , LUO Teng ^2,3 ,  DENG Linhong ^2,3

1. College of Microelectronics and Control Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China;
2. Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, P. R. China;
3. College of Medical and Health Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China;

Corresponding author：

DENG Linhong, Email: dlh@cczu.edu.cn

Keywords：

Biomaterials; Blood compatibility; Electrical impedance tomography; Hemolysis; Coagulation

DOI：

10.7507/1001-5515.202410058

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The evaluation of blood compatibility of biomaterials is crucial for ensuring the clinical safety of implantable medical devices. To address the limitations of traditional testing methods in real-time monitoring and electrical property analysis, this study developed a portable electrical impedance tomography (EIT) system. The system uses a 16-electrode design, operates within a frequency range of 1 to 500 kHz, achieves a signal to noise ratio (SNR) of 69.54 dB at 50 kHz, and has a data collection speed of 20 frames per second. Experimental results show that the EIT system developed in this study is highly consistent with a microplate reader (R²=0.97) in detecting the hemolytic behavior of industrial-grade titanium (TA3) and titanium alloy—titanium 6 aluminum 4 vanadium (TC4) in anticoagulated bovine blood. Additionally, with the support of a multimodal image fusion Gauss-Newton one-step iterative algorithm, the system can accurately locate and monitor in real-time the dynamic changes in blood permeation and coagulation caused by TC4 in vivo. In conclusion, the EIT system developed in this study provides a new and effective method for evaluating the blood compatibility of biomaterials.

Citation： PENG Piao, CHEN Huaihao, CHE Bo, LI Xuan, FAN Chunjian, LIU Lei, LUO Teng, DENG Linhong. Research on a portable electrical impedance tomography system for evaluating blood compatibility of biomaterials. Journal of Biomedical Engineering, 2025, 42(2): 219-227. doi: 10.7507/1001-5515.202410058 Copy

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35.	Fortune S. Voronoi diagrams and Delaunay triangulations//Goodman J E, O'Rourke J. Handbook of Discrete and Computational Geometry. Chapman and Hall/CRC, 2017: 705-721.

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35. Fortune S. Voronoi diagrams and Delaunay triangulations//Goodman J E, O'Rourke J. Handbook of Discrete and Computational Geometry. Chapman and Hall/CRC, 2017: 705-721.

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Research on a portable electrical impedance tomography system for evaluating blood compatibility of biomaterials

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