Objective To review the risks and control of disease transmission in clinical transplantation of human allogenic bone.
Methods The related literature on diseases transmission, risks and control, and tissue banking technology in human allogenic bone application was extensively reviewed and analyzed.
Results The tissue is not sterilized in transmission cases relative to human allogenic bone transplantation reported abroad. While no transmission case was reported domestically because of final sterilization and strict performance during preparation.
Conclusion Strict standard operation, virus inactivation, and final sterilization could effectively control the risks of diseases transmission in human allogenic bone transplantation.
Citation：
LIJing, CHENXueying. RISKS AND CONTROL OF DISEASES TRANSMISSION IN TRANSPLANTAION OF HUMAN ALLOGENIC BONE. Chinese Journal of Reparative and Reconstructive Surgery, 2015, 29(5): 649-651. doi: 10.7507/1002-1892.20150139
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Copyright © the editorial department of Chinese Journal of Reparative and Reconstructive Surgery of West China Medical Publisher. All rights reserved
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- 1. 李宝兴. 同种组织移植与组织库. 北京:原子能出版社, 2010:73.
- 2. 宋会平, 王志强. 异体骨的临床应用. 中国修复重建外科杂志, 2006, 20(1):77-80.
- 3. 刘斌. 同种异体骨的易感疾病风险与控制. 中国矫形外科杂志, 2009, 17(15):1164-1169.
- 4. 许伟. 同种骨应用中的风险与管理. 中国医疗器械信息, 2009, 15(12):6-9.
- 5. 孙世荃, 李宝兴. 同种异体骨移植引起的疾病传播. 中国骨肿瘤骨病, 2003, 2(6):333-335.
- 6. Simonds RJ, Holmberg SD, Hurwitz RL, et al. Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. N Engl J Med, 1992, 326(11):726-732.
- 7. Conrad EU, Gretch DR, Obermeyer KR, et al. Transmission of the hepatitis C virus by tissue transplantation. J Bone Joint Surg (Am), 1995, 77(2):214-224.
- 8. 同种组织移植物生产技术要求(Q/DS. J4001-2007). 太原:山西省医用组织库, 2007.
- 9. 国家质量技术监督局. 中华人民共和国国家标准:GB18280-2007医疗保健产品灭菌-辐射. 北京:中国标准出版社, 2007.
