Progress in biocompatibility and surface modification of nickel titanium shape memory alloys_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

BAI Jiyue ¹ ,  XU Yongqing ² , HE Xiaoqing ² , Li Chuan ² , ZHU Min ²

1. Graduate Management Brigade, Army Medical University, Chongqing, 400038, P.R.China;
2. Department of Orthopedics, Kunming General Hospital of Chengdu Military Command, Kunming Yunnan, 650032, P.R.China;

Corresponding author：

XU Yongqing, Email: xuyongqingkm@163.net

Keywords：

Nickel titanium shape memory alloys; biocampatibility; surface modification

DOI：

10.7507/1002-1892.201709089

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the research progress of biocompatibility and surface modification of nickel titanium shape memory alloys (Ni-Ti SMA). Methods The relative researches about Ni-Ti SMA at home and abroad were reviewed, collated, analyzed, and summarized. Results At present, Ni-Ti SMA as an internal fixation material has been widely used in clinic. It has the following advantages: the super elasticity, the shape memory characteristic, the good wear resistance, and the strong corrosion resistance. It also can effectively avoid the internal fixator rupture caused by stress shielding. After surface modification, the biocompatibility of Ni-Ti SMA has been improved. Conclusion The Ni-Ti SMA is the most promising alloy material for the long-term internal fixator because of its excellent material properties.

Citation： BAI Jiyue, XU Yongqing, HE Xiaoqing, Li Chuan, ZHU Min. Progress in biocompatibility and surface modification of nickel titanium shape memory alloys. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(8): 1091-1095. doi: 10.7507/1002-1892.201709089 Copy

1.	蔡兴博, 丁晶, 徐永清. 镍钛记忆合金在骨科临床中的应用. 国际骨科学杂志, 2017, 38(6): 364-367.
2.	Leitner T, Sabirov I, Pippan R, et al. The effect of severe grain refinement on the damage tolerance of a superelastic NiTi shape memory alloy. J Mech Behav Biomed Mater, 2017, 71: 337-348.
3.	黄亦成, 宓蓉. 镍钛合金在医疗领域应用研究进展. 生物医学工程学进展, 2015, 36(3): 169-172.
4.	马嘉丽, 于振华, 朱明, 等. 镍钛合金血管支架性能研究综述. 金属功能材料, 2015, 22(2): 56-59.
5.	Habijan T, Glogowski T, Kuhn S, et al. Can human mesenchymal stem cells survive on a NiTi implant material subjected to cyclic loading? Acta Biomater, 2011, 7(6): 2733-2739.
6.	郭静, 米丛波, 谭雪英. 4 种镍钛正畸弓丝镍离子析出的体外实验. 中国组织工程研究与临床康复, 2009, 13(21): 4141-4144.
7.	张贺佳, 张扬, 孙晓菊, 等. 3 种正畸用镍钛形状记忆合金弓丝细胞毒性评价. 中国实用口腔科杂志, 2010, 3(8): 477-480.
8.	Kapanen A, Ilvesaro J, Danilov A, et al. Behaviour of nitinol in osteoblast-like ROS-17 cell cultures. Biomaterials, 2002, 23(3): 645-650.
9.	Bogdanski D, Köller M, Müller D, et al. Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material[J]. Biomaterials. 2002, 23(23): 4549-4555.
10.	El Medawar L, Rocher P, Hornez JC, et al. Electrochemical and cytocompatibility assessment of NiTiNOL memory shape alloy for orthodontic use. Biomol Eng, 2002, 19(2-6): 153-160.
11.	Wever DJ, Elstrodt JA, Veldhuizen AG, et al. Scoliosis correction with shape-memory metal: results of an experimental study. Eur Spine J, 2002, 11(2): 100-106.
12.	Olson JL, Velez-Montoya R, Erlanger M. Ocular biocompatibility of nitinol intraocular clips. Invest Ophthalmol Vis Sci, 2012, 53(1): 354-360.
13.	李强, 夏亚一, 刘文忠, 等. 弹性镍钛合金内固定材料表面修饰及其持续动力压应力对骨折愈合的影响. 中国组织工程研究与临床康复, 2007, 11(5): 811-814.
14.	张媛媛, 肖自安, 李周, 等. 镍钛合金在豚鼠听泡的生物相容性观察. 听力学及言语疾病杂志, 2010, 18(3): 211-214.
15.	Assad M, Yahia LH, Rivard CH, et al. In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopy in situ end-labeling (EM-ISEL). J Biomed Mater Res, 1998, 41(1): 154-161.
16.	冯翠娟, 张雪, 王强, 等. 表面氧化镍钛合金对L-929细胞凋亡、总RNA量及caspase-3, 8, 9 mRNA表达影响的研究. 口腔医学, 2011, 31(1): 19-22.
17.	冯翠娟, 王强, 张雪, 等. 镍钛合金表面氧化处理对L-929细胞凋亡相关基因bax/bcl-2 mRNA表达的影响. 中国组织工程研究与临床康复, 2010, 14(12): 2145-2148.
18.	李慧萍. Cr离子注入镍钛合金的表面改性研究. 北京: 北方工业大学, 2014.
19.	Dudek K, Goryczka T. Electrophoretic deposition and characterization of thin hydroxyapatite coatings formed on the surface of NiTi shape memory alloy. Ceramics International, 2016, 42(16): 19124-19132.
20.	张海军, 王栓科, 赵斌. HAP涂层镍钛记忆合金的组织相容性. 中国修复重建外科杂志, 2009, 23(4): 468-472.
21.	朱姿虹. NiTi合金表面无镍层及生物改性层制备与表征. 镇江: 江苏大学, 2016.
22.	Choi J, Bogdanski D, Köller M, et al. Calcium phosphate coating of nickel-titanium shape-memory alloys. Coating procedure and adherence of leukocytes and platelets. Biomaterials, 2003, 24(21): 3689-3696.
23.	Chu CL, Guo C, Sheng XB, et al. Microstructure, nickel suppression and mechanical characteristics of electropolished and photoelectrocatalytically oxidized biomedical nickel titanium shape memory alloy. Acta Biomater, 2009, 5(6): 2238-2245.
24.	Thierry B, Tabrizian M, Trepanier C, et al. Effect of surface treatment and sterilization processes on the corrosion behavior of NiTi shape memory alloy. J Biomed Mater Res, 2000, 51(4): 685-693.
25.	Trépanier C, Tabrizian M, Yahia LH, et al. Effect of modification of oxide layer on NiTi stent corrosion resistance. J Biomed Mater Res, 1998, 43(4): 433-440.
26.	Armitage DA, Parker TL, Grant DM. Biocompatibility and hemocompatibility of surface-modified NiTi alloys. J Biomed Mater Res A, 2003, 66(1): 129-137.
27.	Xu JL, Zhong ZC, Yu DZ, et al. Effect of micro-arc oxidation surface modification on the properties of the NiTi shape memory alloy. J Mater Sci Mater Med, 2012, 23(12): 2839-2846.
28.	Kobayashi S, Ohgoe Y, Ozeki K, et al. Dissolution effect and cytotoxicity of diamond-like carbon coatings on orthodontic archwires. J Mater Sci Mater Med, 2007, 18(12): 2263-2268.
29.	Kapanen A, Kinnunen A, Ryhänen J, et al. TGF-beta1 secretion of ROS-17/2.8 cultures on NiTi implant material. Biomaterials, 2002, 23(16): 3341-3346.
30.	汪爱媛, 李永滨, 许文静, 等. 钛铌涂层镍钛记忆合金的生物安全性及生物相容性. 中国医药生物技术, 2010, 5(1): 32-37.
31.	苏向东, 韩锋, 何力, 等. 低温去合金化脱镍处理镍钛记忆合金的表面特性. 稀有金属材料与工程, 2011, 40(8): 1446-1449.
32.	袁凌伟, 苏向东, 鲁茂森, 等. 低温去合金化镍钛形状记忆合金的血液相容性.中国组织工程研究与临床康复, 2009, 13(34): 6663-6666.
33.	Köhl M, Habijan T, Bram M, et al. Powder metallurgical near-net-shape fabrication of porous NiTi shape memory alloys for use as long-term implants by the combination of the metal injection molding process with the space-holder technique. Advanced Engineering Materials, 2009, 11(12): 959-968.
34.	Wu S, Liu X, Wu G, et al. Wear mechanism and tribological characteristics of porous NiTi shape memory alloy for bone scaffold. J Biomed Mater Res A, 2013, 101(9): 2586-2601.

1. 蔡兴博, 丁晶, 徐永清. 镍钛记忆合金在骨科临床中的应用. 国际骨科学杂志, 2017, 38(6): 364-367.
2. Leitner T, Sabirov I, Pippan R, et al. The effect of severe grain refinement on the damage tolerance of a superelastic NiTi shape memory alloy. J Mech Behav Biomed Mater, 2017, 71: 337-348.
3. 黄亦成, 宓蓉. 镍钛合金在医疗领域应用研究进展. 生物医学工程学进展, 2015, 36(3): 169-172.
4. 马嘉丽, 于振华, 朱明, 等. 镍钛合金血管支架性能研究综述. 金属功能材料, 2015, 22(2): 56-59.
5. Habijan T, Glogowski T, Kuhn S, et al. Can human mesenchymal stem cells survive on a NiTi implant material subjected to cyclic loading? Acta Biomater, 2011, 7(6): 2733-2739.
6. 郭静, 米丛波, 谭雪英. 4 种镍钛正畸弓丝镍离子析出的体外实验. 中国组织工程研究与临床康复, 2009, 13(21): 4141-4144.
7. 张贺佳, 张扬, 孙晓菊, 等. 3 种正畸用镍钛形状记忆合金弓丝细胞毒性评价. 中国实用口腔科杂志, 2010, 3(8): 477-480.
8. Kapanen A, Ilvesaro J, Danilov A, et al. Behaviour of nitinol in osteoblast-like ROS-17 cell cultures. Biomaterials, 2002, 23(3): 645-650.
9. Bogdanski D, Köller M, Müller D, et al. Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti material[J]. Biomaterials. 2002, 23(23): 4549-4555.
10. El Medawar L, Rocher P, Hornez JC, et al. Electrochemical and cytocompatibility assessment of NiTiNOL memory shape alloy for orthodontic use. Biomol Eng, 2002, 19(2-6): 153-160.
11. Wever DJ, Elstrodt JA, Veldhuizen AG, et al. Scoliosis correction with shape-memory metal: results of an experimental study. Eur Spine J, 2002, 11(2): 100-106.
12. Olson JL, Velez-Montoya R, Erlanger M. Ocular biocompatibility of nitinol intraocular clips. Invest Ophthalmol Vis Sci, 2012, 53(1): 354-360.
13. 李强, 夏亚一, 刘文忠, 等. 弹性镍钛合金内固定材料表面修饰及其持续动力压应力对骨折愈合的影响. 中国组织工程研究与临床康复, 2007, 11(5): 811-814.
14. 张媛媛, 肖自安, 李周, 等. 镍钛合金在豚鼠听泡的生物相容性观察. 听力学及言语疾病杂志, 2010, 18(3): 211-214.
15. Assad M, Yahia LH, Rivard CH, et al. In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopy in situ end-labeling (EM-ISEL). J Biomed Mater Res, 1998, 41(1): 154-161.
16. 冯翠娟, 张雪, 王强, 等. 表面氧化镍钛合金对L-929细胞凋亡、总RNA量及caspase-3, 8, 9 mRNA表达影响的研究. 口腔医学, 2011, 31(1): 19-22.
17. 冯翠娟, 王强, 张雪, 等. 镍钛合金表面氧化处理对L-929细胞凋亡相关基因bax/bcl-2 mRNA表达的影响. 中国组织工程研究与临床康复, 2010, 14(12): 2145-2148.
18. 李慧萍. Cr离子注入镍钛合金的表面改性研究. 北京: 北方工业大学, 2014.
19. Dudek K, Goryczka T. Electrophoretic deposition and characterization of thin hydroxyapatite coatings formed on the surface of NiTi shape memory alloy. Ceramics International, 2016, 42(16): 19124-19132.
20. 张海军, 王栓科, 赵斌. HAP涂层镍钛记忆合金的组织相容性. 中国修复重建外科杂志, 2009, 23(4): 468-472.
21. 朱姿虹. NiTi合金表面无镍层及生物改性层制备与表征. 镇江: 江苏大学, 2016.
22. Choi J, Bogdanski D, Köller M, et al. Calcium phosphate coating of nickel-titanium shape-memory alloys. Coating procedure and adherence of leukocytes and platelets. Biomaterials, 2003, 24(21): 3689-3696.
23. Chu CL, Guo C, Sheng XB, et al. Microstructure, nickel suppression and mechanical characteristics of electropolished and photoelectrocatalytically oxidized biomedical nickel titanium shape memory alloy. Acta Biomater, 2009, 5(6): 2238-2245.
24. Thierry B, Tabrizian M, Trepanier C, et al. Effect of surface treatment and sterilization processes on the corrosion behavior of NiTi shape memory alloy. J Biomed Mater Res, 2000, 51(4): 685-693.
25. Trépanier C, Tabrizian M, Yahia LH, et al. Effect of modification of oxide layer on NiTi stent corrosion resistance. J Biomed Mater Res, 1998, 43(4): 433-440.
26. Armitage DA, Parker TL, Grant DM. Biocompatibility and hemocompatibility of surface-modified NiTi alloys. J Biomed Mater Res A, 2003, 66(1): 129-137.
27. Xu JL, Zhong ZC, Yu DZ, et al. Effect of micro-arc oxidation surface modification on the properties of the NiTi shape memory alloy. J Mater Sci Mater Med, 2012, 23(12): 2839-2846.
28. Kobayashi S, Ohgoe Y, Ozeki K, et al. Dissolution effect and cytotoxicity of diamond-like carbon coatings on orthodontic archwires. J Mater Sci Mater Med, 2007, 18(12): 2263-2268.
29. Kapanen A, Kinnunen A, Ryhänen J, et al. TGF-beta1 secretion of ROS-17/2.8 cultures on NiTi implant material. Biomaterials, 2002, 23(16): 3341-3346.
30. 汪爱媛, 李永滨, 许文静, 等. 钛铌涂层镍钛记忆合金的生物安全性及生物相容性. 中国医药生物技术, 2010, 5(1): 32-37.
31. 苏向东, 韩锋, 何力, 等. 低温去合金化脱镍处理镍钛记忆合金的表面特性. 稀有金属材料与工程, 2011, 40(8): 1446-1449.
32. 袁凌伟, 苏向东, 鲁茂森, 等. 低温去合金化镍钛形状记忆合金的血液相容性.中国组织工程研究与临床康复, 2009, 13(34): 6663-6666.
33. Köhl M, Habijan T, Bram M, et al. Powder metallurgical near-net-shape fabrication of porous NiTi shape memory alloys for use as long-term implants by the combination of the metal injection molding process with the space-holder technique. Advanced Engineering Materials, 2009, 11(12): 959-968.
34. Wu S, Liu X, Wu G, et al. Wear mechanism and tribological characteristics of porous NiTi shape memory alloy for bone scaffold. J Biomed Mater Res A, 2013, 101(9): 2586-2601.

Previous Article
更新皮肤伤口诊疗理念，建立愈合质量分级，提高诊疗水平
Next Article
Research progress of chronic wound debridement

Chinese Journal of Reparative and Reconstructive Surgery

Progress in biocompatibility and surface modification of nickel titanium shape memory alloys

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content