Research progress and clinical application of ventricular assist blood pump_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

 ZHANGYan , SUNHansong , HUShengshou

Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, P.R.China;

Corresponding author：

ZHANGYan, Email: waikezhangyan@126.com

Keywords：

Ventricular assist devices; blood pump; heart failure

DOI：

10.7507/1007-4848.201503048

Video：

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Heart failure is a leading cause of death in human populations. Because of the insufficient numbers of donor hearts, ventricular assist as a way for the treatment of heart failure and its clinical use is increasing. Initially ventricular assist devices were approved as a bridge-to-recovery indication, and these systems are now increasingly being used as a bridge-to-transplant (BTT) , destination therapy (DT) or permanent support. According to the different structure and working mechanism, ventricular assist device is generally divided into three generation. This review makes a summary on the type of blood pump and its research progress in clinical application.

Citation： ZHANGYan, SUNHansong, HUShengshou. Research progress and clinical application of ventricular assist blood pump. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2017, 24(2): 152-155. doi: 10.7507/1007-4848.201503048 Copy

1.	Bui AL, Horwich TB, Fonarow GC. Epidemiology and risk profile of heart failure. Nat Rev Cardiol, 2011, 8(1): 30-41.
2.	Kirklin JK, Naftel DC, Pagani FD, et al. Sixth INTERMACS annual report: a 10, 000-patient database. J Heart Lung Transplant, 2014, 33(6): 555-564.
3.	Debakey ME. Left ventricular bypass pump for cardiac assistance. Clinical experience. Am J Cardiol, 1971, 27(1): 3-11.
4.	Portner PM, Oyer PE, McGregor CGA. First human use of an electrically powered implantable entricular assist system. Int J Artif Organs, 1985, 9: 36.
5.	Neragi-Miandoab S. A ventricular assist device as a bridge to recovery, decision making, or transplantation in patients with advanced cardiac failure. Surg Today, 2012, 42(10): 917-926.
6.	Tsiouris A, Brewer RJ, Borgi J, et al. Continuous-flow left ventricular assist device implantation as a bridge to transplantation or destination therapy: racial disparities in outcomes. J Heart Lung Transplant, 2013, 32(3): 299-304.
7.	Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol, 2013, 62(16): e147-e239.
8.	吴清玉, 杨研, 郭少先, 等. 应用左心室机械辅助装置行心脏移植前过渡治疗2年一例. 中华外科杂志, 2004, 42(24): 69-70.
9.	胡盛寿, 孙寒松, 罗新锦, 等. BVS5000左心辅助装置在心力衰竭患者中的临床应用体会. 中华外科杂志, 2008, 46(7): 531-533.
10.	Wheeldon DR, Jansen PG, Portner PM. The Novacor electrical implantable left ventricular assist system. Perfusion, 2000, 15(4): 355-361.
11.	Frazier OH, Rose EA, Oz MC, et al. Multicenter clinical evaluation of the heartmate; vented electric left ventricular assist system in patients awaiting heart transplantation. J Heart Lung Transplant, 2001, 20(2): 201-202.
12.	Slater JP, Rose EA, Levin HR, et al. Low thromboembolic risk without anticoagulation using advanced-design left ventricular assist devices. Ann Thorac Surg, 1996, 62(5): 1321-1328.
13.	Lietz K, Long JW, Kfoury AG, et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation, 2007, 116(5): 497-505.
14.	Rose EA, Moskowitz AJ, Packer M, et al. The REMATCH trial: rationale, design, and end points. Randomized evaluation of mechanical assistance for the treatment of congestive heart failure. Ann Thorac Surg, 1999, 67(3): 723-730.
15.	Simon D, Fischer S, Grossman A, et al. Left ventricular assist device-related infection: treatment and outcome. Clin Infect Dis, 2005, 40(8): 1108-1115.
16.	Lima B, Mack M, Gonzalez-Stawinski GV. Ventricular assist devices: The future is now. Trends Cardiovasc Med, 2015, 25(4): 360-369.
17.	Carpenter BA, Gonzalez CJ, Jessen SL, et al. A brief review of ventricular assist devices and a recommended protocol for pathology evaluations. Cardiovasc Pathol, 2013, 22(5): 408-415.
18.	Cho YH, Deo SV, Schirger JA, et al. Implantation of a HeartMate II left ventricular assist device via left thoracotomy. Ann Thorac Surg, 2012, 94(5): 1712-1714.
19.	Kirklin JK, Naftel DC, Pagani FD, et al. Sixth INTERMACS annual report: a 10, 000-patient database. J Heart Lung Transplant, 2014, 33(6): 555-564.
20.	Miller LW, Pagani FD, Russell SD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med, 2007, 357(9): 885-896.
21.	Slaughter MS, Rogers JG, Milano CA, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med, 2009, 361(23): 2241-2251.
22.	Jorde UP, Kushwaha SS, Tatooles AJ, et al. Results of the destination therapy post-food and drug administration approval study with a continuous flow left ventricular assist device: a prospective study using the INTERMACS registry (Interagency Registry for Mechanically Assisted Circulatory Support). J Am Coll Cardiol, 2014, 63(17): 1751-1757.
23.	Jarvik R. Jarvik 2000 pump technology and miniaturization. Heart Fail Clin, 2014, 10(1 Suppl): S27-S38.
24.	Noon GP, Loebe M. Current status of the MicroMed DeBakey noon ventricular assist device. Tex Heart Inst J, 2010, 37(6): 652-653.
25.	Dell'Aquila AM, Schneider SR, Stypmann J, et al. Survival results after implantation of intrapericardial third-generation centrifugal assist device: an INTERMACS-matched comparison analysis. Artif Organs, 2014, 38(5): 383-390.
26.	Critoph C, Chih S, Baumwol J. The world's longest-supported HeartWare ventricular assist device patient: 6 years and counting on minimal anticoagulation. Artif Organs, 2014, 38(5): 434-435.
27.	Nakashima K, Kirsch ME, Vermes E, et al. Off-pump replacement of the INCOR implantable axial-flow pump. J Heart Lung Transplant, 2009, 28(2): 199-201.
28.	Moazami N, Steffen RJ, Naka Y, et al. Lessons learned from the first fully magnetically levitated centrifugal LVAD trial in the United States: the Dura Heart trial. Ann Thorac Surg, 2014, 98(2): 541-547.
29.	Schmitto JD, Hanke JS, Rojas SV, et al. First implantation in man of a new magnetically levitated left ventricular assist device (HeartMate III). J Heart Lung Transplant, 2015, 34(6): 858-860.
30.	Strueber M, Larbalestier R, Jansz P, et al. Results of the post-market Registry to Evaluate the HeartWare Left Ventricular Assist System (ReVOLVE). J Heart Lung Transplant, 2014, 33(5): 486-491.
31.	Aaronson KD, Slaughter MS Miller LW. HeartWare Ventricular Assist Device (HVAD) Bridge to Transplant ADVANCE Trial Investigators. Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation. Circulation, 2012, 125: 3191-3200.
32.	Molina EJ, Boyce SW. Current status of left ventricular assist device technology. Semin Thorac Cardiovasc Surg, 2013, 25(1): 56-63.
33.	Popov AF, Hosseini MT, Zych B, et al. HeartWare left ventricular assist device implantation through bilateral anterior thoracotomy. Ann Thorac Surg, 2012, 93(2): 674-676.
34.	Komoda T, Komoda S, Dandel M, et al. Explantation of INCOR left ventricular assist device after myocardial recovery. J Card Surg, 2008, 23(6): 642-647.
35.	Schmid C, Tjan TD, Etz C, et al. First clinical experience with the Incor left ventricular assist device. J Heart Lung Transplant, 2005, 24(9): 1188-1194.
36.	Agarwal S, High KM. Newer-generation ventricular assist devices. Best Pract Res Clin Anaesthesiol, 2012, 26(2): 117-130.
37.	Sakaguchi T, Matsumiya G, Yoshioka D, et al. DuraHeart magnetically levitated left ventricular assist device: Osaka University experience. Circ J, 2013, 77(7): 1736-1741.

1. Bui AL, Horwich TB, Fonarow GC. Epidemiology and risk profile of heart failure. Nat Rev Cardiol, 2011, 8(1): 30-41.
2. Kirklin JK, Naftel DC, Pagani FD, et al. Sixth INTERMACS annual report: a 10, 000-patient database. J Heart Lung Transplant, 2014, 33(6): 555-564.
3. Debakey ME. Left ventricular bypass pump for cardiac assistance. Clinical experience. Am J Cardiol, 1971, 27(1): 3-11.
4. Portner PM, Oyer PE, McGregor CGA. First human use of an electrically powered implantable entricular assist system. Int J Artif Organs, 1985, 9: 36.
5. Neragi-Miandoab S. A ventricular assist device as a bridge to recovery, decision making, or transplantation in patients with advanced cardiac failure. Surg Today, 2012, 42(10): 917-926.
6. Tsiouris A, Brewer RJ, Borgi J, et al. Continuous-flow left ventricular assist device implantation as a bridge to transplantation or destination therapy: racial disparities in outcomes. J Heart Lung Transplant, 2013, 32(3): 299-304.
7. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol, 2013, 62(16): e147-e239.
8. 吴清玉, 杨研, 郭少先, 等. 应用左心室机械辅助装置行心脏移植前过渡治疗2年一例. 中华外科杂志, 2004, 42(24): 69-70.
9. 胡盛寿, 孙寒松, 罗新锦, 等. BVS5000左心辅助装置在心力衰竭患者中的临床应用体会. 中华外科杂志, 2008, 46(7): 531-533.
10. Wheeldon DR, Jansen PG, Portner PM. The Novacor electrical implantable left ventricular assist system. Perfusion, 2000, 15(4): 355-361.
11. Frazier OH, Rose EA, Oz MC, et al. Multicenter clinical evaluation of the heartmate; vented electric left ventricular assist system in patients awaiting heart transplantation. J Heart Lung Transplant, 2001, 20(2): 201-202.
12. Slater JP, Rose EA, Levin HR, et al. Low thromboembolic risk without anticoagulation using advanced-design left ventricular assist devices. Ann Thorac Surg, 1996, 62(5): 1321-1328.
13. Lietz K, Long JW, Kfoury AG, et al. Outcomes of left ventricular assist device implantation as destination therapy in the post-REMATCH era: implications for patient selection. Circulation, 2007, 116(5): 497-505.
14. Rose EA, Moskowitz AJ, Packer M, et al. The REMATCH trial: rationale, design, and end points. Randomized evaluation of mechanical assistance for the treatment of congestive heart failure. Ann Thorac Surg, 1999, 67(3): 723-730.
15. Simon D, Fischer S, Grossman A, et al. Left ventricular assist device-related infection: treatment and outcome. Clin Infect Dis, 2005, 40(8): 1108-1115.
16. Lima B, Mack M, Gonzalez-Stawinski GV. Ventricular assist devices: The future is now. Trends Cardiovasc Med, 2015, 25(4): 360-369.
17. Carpenter BA, Gonzalez CJ, Jessen SL, et al. A brief review of ventricular assist devices and a recommended protocol for pathology evaluations. Cardiovasc Pathol, 2013, 22(5): 408-415.
18. Cho YH, Deo SV, Schirger JA, et al. Implantation of a HeartMate II left ventricular assist device via left thoracotomy. Ann Thorac Surg, 2012, 94(5): 1712-1714.
19. Kirklin JK, Naftel DC, Pagani FD, et al. Sixth INTERMACS annual report: a 10, 000-patient database. J Heart Lung Transplant, 2014, 33(6): 555-564.
20. Miller LW, Pagani FD, Russell SD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med, 2007, 357(9): 885-896.
21. Slaughter MS, Rogers JG, Milano CA, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med, 2009, 361(23): 2241-2251.
22. Jorde UP, Kushwaha SS, Tatooles AJ, et al. Results of the destination therapy post-food and drug administration approval study with a continuous flow left ventricular assist device: a prospective study using the INTERMACS registry (Interagency Registry for Mechanically Assisted Circulatory Support). J Am Coll Cardiol, 2014, 63(17): 1751-1757.
23. Jarvik R. Jarvik 2000 pump technology and miniaturization. Heart Fail Clin, 2014, 10(1 Suppl): S27-S38.
24. Noon GP, Loebe M. Current status of the MicroMed DeBakey noon ventricular assist device. Tex Heart Inst J, 2010, 37(6): 652-653.
25. Dell'Aquila AM, Schneider SR, Stypmann J, et al. Survival results after implantation of intrapericardial third-generation centrifugal assist device: an INTERMACS-matched comparison analysis. Artif Organs, 2014, 38(5): 383-390.
26. Critoph C, Chih S, Baumwol J. The world's longest-supported HeartWare ventricular assist device patient: 6 years and counting on minimal anticoagulation. Artif Organs, 2014, 38(5): 434-435.
27. Nakashima K, Kirsch ME, Vermes E, et al. Off-pump replacement of the INCOR implantable axial-flow pump. J Heart Lung Transplant, 2009, 28(2): 199-201.
28. Moazami N, Steffen RJ, Naka Y, et al. Lessons learned from the first fully magnetically levitated centrifugal LVAD trial in the United States: the Dura Heart trial. Ann Thorac Surg, 2014, 98(2): 541-547.
29. Schmitto JD, Hanke JS, Rojas SV, et al. First implantation in man of a new magnetically levitated left ventricular assist device (HeartMate III). J Heart Lung Transplant, 2015, 34(6): 858-860.
30. Strueber M, Larbalestier R, Jansz P, et al. Results of the post-market Registry to Evaluate the HeartWare Left Ventricular Assist System (ReVOLVE). J Heart Lung Transplant, 2014, 33(5): 486-491.
31. Aaronson KD, Slaughter MS Miller LW. HeartWare Ventricular Assist Device (HVAD) Bridge to Transplant ADVANCE Trial Investigators. Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation. Circulation, 2012, 125: 3191-3200.
32. Molina EJ, Boyce SW. Current status of left ventricular assist device technology. Semin Thorac Cardiovasc Surg, 2013, 25(1): 56-63.
33. Popov AF, Hosseini MT, Zych B, et al. HeartWare left ventricular assist device implantation through bilateral anterior thoracotomy. Ann Thorac Surg, 2012, 93(2): 674-676.
34. Komoda T, Komoda S, Dandel M, et al. Explantation of INCOR left ventricular assist device after myocardial recovery. J Card Surg, 2008, 23(6): 642-647.
35. Schmid C, Tjan TD, Etz C, et al. First clinical experience with the Incor left ventricular assist device. J Heart Lung Transplant, 2005, 24(9): 1188-1194.
36. Agarwal S, High KM. Newer-generation ventricular assist devices. Best Pract Res Clin Anaesthesiol, 2012, 26(2): 117-130.
37. Sakaguchi T, Matsumiya G, Yoshioka D, et al. DuraHeart magnetically levitated left ventricular assist device: Osaka University experience. Circ J, 2013, 77(7): 1736-1741.

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