Research Progress on Related Gene of Stem Cell Therapy for Acute-on-Chronic Liver Failure_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

 MALin-jie , CHENXiao , ZOULong ,  CHENGang , LIUHong

Department of Hepatobiliary and Pancreatic Surgery, Ganmei Hospital Affiliated to Kunming Medical University, Kunming 65000, Yunnan Province, China;

Corresponding author：

CHENGang, Email: chengang201501@126.com

Keywords：

Stem cells; Acute-on-chronic liver failure; Gene; Mechanism

DOI：

10.7507/1007-9424.20160327

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the changes and mechanism of related genes induced by stem cell therapy in acute-on-chronic liver failure (ACLF) in recent years, and in order to guide the clinical value of ACLF and curative effect evaluation. Methods Through searching Wanfang med, CNKI, Pubmed database and so on in recent years, the differentially expressed genes induced by stem cell therapy for ACLF in recent years was retrieved and the changes of related genes induced during the treatment process were discussed. Results Both at home and abroad had reported that stem cell therapy in the process of ACLF caused mir-27b, TRAIL, and Tg737 genetic changes, some genetic changes had an fixed change trend. Conclusions Stem cells in the treatment of ACLF, cause mir-27b, TRAIL, Tg737 genetic changes, which can provides a new way and method for monitoring stem cell therapy ACLF.

Citation： MA Lin-jie, CHEN Xiao, ZOU Long, CHEN Gang, LIU Hong. Research Progress on Related Gene of Stem Cell Therapy for Acute-on-Chronic Liver Failure. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2016, 23(10): 1276-1279. doi: 10.7507/1007-9424.20160327 Copy

1.	中华医学会感染病学分会肝衰竭与人工肝学组、中华医学会肝病学分会重型肝痛与人工肝学组. 肝衰竭诊疗指南. 中华临床感染病杂志, 2012, 5(6):321-327.
2.	Sarin SK, Choudhury A. Acute-on-chronic liver failure:terminology, mechanisms and management. Nat Rev Gastroenterol Hepatol, 2016, 13(3):131-149.
3.	Zhang J, Gao S, Duan Z, et al. Overview on acute-on-chronic liver failure. Front Med, 2016, 10(1):1-17.
4.	Shi M, Zhang Z, Xu R, et al. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Stem Cells Transl Med, 2012, 1(10):725-731.
5.	Liu XY, Peng F, Pan YJ, et al. Advanced therapeutic strategies for HBV-related acute-on-chronic liver failure. Hepatobiliary Pancreat Dis Int, 2015, 14(4):354-360.
6.	Lehmann TP, Korski K, Gryczka R, et al. Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. Mol Med Rep, 2015, 12(3):4692-4702.
7.	Jiang J, Yi B, Qin C, et al. Upregulation of microRNA-27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2-mediated ERK signaling. Mol Med Rep, 2016, 13(3):2267-2272.
8.	He S, Zhang J, Lin J, et al. Expression and function of microRNA-27b in hepatocellular carcinoma. Mol Med Rep, 2016, 13(3):2801-2808.
9.	Lü MH, Li CZ, Hu CJ, et al. MicroRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1α in vitro. Biochem Biophys Res Commun, 2012, 421(2):389-395.
10.	李长珠. 骨髓来源细胞参与肝脏损伤后修复的作用及其机制的实验研究. 第三军医大学硕士学位论文, 2011.
11.	李光耀, 刘孟刚, 赵晓彪, 等.大鼠肝再生过程中Mir27b与Tumb1表达相关性研究. 免疫学杂志, 2015,31(1):58-62.
12.	Wu XQ, Dai Y, Yang Y, et al. Emerging role of miRNAs in regulating macrophage activation and polarization in immune response and inflammation. Immunology, 2016, 148(3):237-248.
13.	Lü MH, Hu CJ, Chen L, et al. miR-27b represses migration of mouse MSCs to burned margins and prolongs wound repair through silencing SDF-1a. PLoS One, 2013, 8(7):e68972.
14.	Chen KD, Hsu LW, Goto S, et al. Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats. Transplant Proc, 2014, 46(4):1198-1200.
15.	张爱民, 游绍莉, 万志红, 等. 乙型肝炎病毒相关慢加急性肝衰竭患者肝纤维化、肝功能、病毒学指标及甲胎蛋白水平与预后的关系. 临床肝胆病杂志, 2012, 28(6):459-461.
16.	Ji J, Zhang J, Huang G, et al. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett, 2009,583(4):759-766.
17.	史晓盟, 杨文卓, 匡大鹏, 等. miRNA-27b对人星状细胞系脂代谢与迁移能力的影响.同济大学学报:医学版, 2014, 35(4):19-28.
18.	Chen KD, Goto S, Hsu LW, et al. Identification of miR-27b as a novel signature from the mRNA profiles of adipose-derived mesenchymal stem cells involved in the tolerogenic response. PLoS One,2013,8(4):e60492.
19.	Yan X, Xu L, Qi J, et al. sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease. Immunogenetics, 2009, 61(8):551-556.
20.	漆志平, 赵永忠. TRAIL及其受体与慢性肝病关系的研究进展. 医学综述, 2010, 16(5):658-661.
21.	杨文, 覃山羽, 姜海行, 等.骨髓间充质干细胞体外调控肝星状细胞死亡受体5的表达.中国组织工程研究, 2012, 27(16):4947-4952.
22.	刘成侠. 肝癌穿刺组织中抑癌基因T9737的表达情况及其功能分析. 海南医学院学报, 2015, 22(3):229-232.
23.	张君红, 姜海行, 孟云超, 等.大鼠骨髓间充质干细胞旁分泌HGF上调肝星状细胞DR5及caspase-8的表达. 基础医学与临床, 2012,32(7):804-808.
24.	Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, et al. TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. Lab Invest, 2015, 95(2):223-236.
25.	Wan Z, Xie G, Wu Y, et al. Cytokines elevated in patients with HBV-related acute-on-chronic liver failure promote NK cell mediated cytotoxicity through TRAIL. Dig Liver Dis, 2016, 48(5):528-535.
26.	何选秋, 李咏茵, 张小勇, 等. 自然杀伤细胞在肝脏疾病中的作用. 肝脏, 2014, 19(2):128-131.
27.	陈公英, 何剑琴, 吕国才, 等. 乙型肝炎患者CD4⁺,CD8⁺ T淋巴细胞TRAIL增高与肝损伤相关性的研究. 中华肝脏病杂志, 2004, 12(5):284-286.
28.	邹勇. 肝脏自然杀伤细胞在病毒诱导的肝衰竭中的作用. 华中科技大学博士学位论文, 2009.
29.	王艳海. 慢性乙型肝炎患者外周血NK细胞表达研究. 疾病监测与控制杂志, 2012, 6(10):582-584.
30.	高恒. 分泌型TRAIL基因修饰人脂肪干细胞靶向脑胶质瘤治疗的研究. 苏州大学博士论文, 2013.
31.	高远, 阮柏, 张卓, 等. 抑癌基因Tg737下调对肝癌细胞增殖的影响及其机制. 中华肝胆外科杂志, 2014, 20(12):848-851.
32.	党立力. Tg737基因在胎肝干细胞分化过程中的作用及机制研究. 第四军医大学硕士学位论文, 2014.
33.	党立力, 黄启科, 周亮, 等, T9737基因参与胎肝干细胞正常分化的机制研究. 肝胆外科杂志, 2014, 22(1):55-58.
34.	You N, Liu W, Zhong X, et al. Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell-cycle progression and differentiation arrest. Mol Carcinog, 2012, 51(8):659-673.
35.	王雪. MicroRNA介导间充质干细胞向肝细胞转分化的研究. 第四军医大学硕士学位论文, 2014.

1. 中华医学会感染病学分会肝衰竭与人工肝学组、中华医学会肝病学分会重型肝痛与人工肝学组. 肝衰竭诊疗指南. 中华临床感染病杂志, 2012, 5(6):321-327.
2. Sarin SK, Choudhury A. Acute-on-chronic liver failure:terminology, mechanisms and management. Nat Rev Gastroenterol Hepatol, 2016, 13(3):131-149.
3. Zhang J, Gao S, Duan Z, et al. Overview on acute-on-chronic liver failure. Front Med, 2016, 10(1):1-17.
4. Shi M, Zhang Z, Xu R, et al. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Stem Cells Transl Med, 2012, 1(10):725-731.
5. Liu XY, Peng F, Pan YJ, et al. Advanced therapeutic strategies for HBV-related acute-on-chronic liver failure. Hepatobiliary Pancreat Dis Int, 2015, 14(4):354-360.
6. Lehmann TP, Korski K, Gryczka R, et al. Relative levels of let-7a, miR-17, miR-27b, miR-125a, miR-125b and miR-206 as potential molecular markers to evaluate grade, receptor status and molecular type in breast cancer. Mol Med Rep, 2015, 12(3):4692-4702.
7. Jiang J, Yi B, Qin C, et al. Upregulation of microRNA-27b contributes to the migration and invasion of gastric cancer cells via the inhibition of sprouty2-mediated ERK signaling. Mol Med Rep, 2016, 13(3):2267-2272.
8. He S, Zhang J, Lin J, et al. Expression and function of microRNA-27b in hepatocellular carcinoma. Mol Med Rep, 2016, 13(3):2801-2808.
9. Lü MH, Li CZ, Hu CJ, et al. MicroRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1α in vitro. Biochem Biophys Res Commun, 2012, 421(2):389-395.
10. 李长珠. 骨髓来源细胞参与肝脏损伤后修复的作用及其机制的实验研究. 第三军医大学硕士学位论文, 2011.
11. 李光耀, 刘孟刚, 赵晓彪, 等.大鼠肝再生过程中Mir27b与Tumb1表达相关性研究. 免疫学杂志, 2015,31(1):58-62.
12. Wu XQ, Dai Y, Yang Y, et al. Emerging role of miRNAs in regulating macrophage activation and polarization in immune response and inflammation. Immunology, 2016, 148(3):237-248.
13. Lü MH, Hu CJ, Chen L, et al. miR-27b represses migration of mouse MSCs to burned margins and prolongs wound repair through silencing SDF-1a. PLoS One, 2013, 8(7):e68972.
14. Chen KD, Hsu LW, Goto S, et al. Regulation of heme oxygenase 1 expression by miR-27b with stem cell therapy for liver regeneration in rats. Transplant Proc, 2014, 46(4):1198-1200.
15. 张爱民, 游绍莉, 万志红, 等. 乙型肝炎病毒相关慢加急性肝衰竭患者肝纤维化、肝功能、病毒学指标及甲胎蛋白水平与预后的关系. 临床肝胆病杂志, 2012, 28(6):459-461.
16. Ji J, Zhang J, Huang G, et al. Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation. FEBS Lett, 2009,583(4):759-766.
17. 史晓盟, 杨文卓, 匡大鹏, 等. miRNA-27b对人星状细胞系脂代谢与迁移能力的影响.同济大学学报:医学版, 2014, 35(4):19-28.
18. Chen KD, Goto S, Hsu LW, et al. Identification of miR-27b as a novel signature from the mRNA profiles of adipose-derived mesenchymal stem cells involved in the tolerogenic response. PLoS One,2013,8(4):e60492.
19. Yan X, Xu L, Qi J, et al. sTRAIL levels and TRAIL gene polymorphisms in Chinese patients with fatty liver disease. Immunogenetics, 2009, 61(8):551-556.
20. 漆志平, 赵永忠. TRAIL及其受体与慢性肝病关系的研究进展. 医学综述, 2010, 16(5):658-661.
21. 杨文, 覃山羽, 姜海行, 等.骨髓间充质干细胞体外调控肝星状细胞死亡受体5的表达.中国组织工程研究, 2012, 27(16):4947-4952.
22. 刘成侠. 肝癌穿刺组织中抑癌基因T9737的表达情况及其功能分析. 海南医学院学报, 2015, 22(3):229-232.
23. 张君红, 姜海行, 孟云超, 等.大鼠骨髓间充质干细胞旁分泌HGF上调肝星状细胞DR5及caspase-8的表达. 基础医学与临床, 2012,32(7):804-808.
24. Fernández-Álvarez S, Gutiérrez-de Juan V, Zubiete-Franco I, et al. TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. Lab Invest, 2015, 95(2):223-236.
25. Wan Z, Xie G, Wu Y, et al. Cytokines elevated in patients with HBV-related acute-on-chronic liver failure promote NK cell mediated cytotoxicity through TRAIL. Dig Liver Dis, 2016, 48(5):528-535.
26. 何选秋, 李咏茵, 张小勇, 等. 自然杀伤细胞在肝脏疾病中的作用. 肝脏, 2014, 19(2):128-131.
27. 陈公英, 何剑琴, 吕国才, 等. 乙型肝炎患者CD4⁺,CD8⁺ T淋巴细胞TRAIL增高与肝损伤相关性的研究. 中华肝脏病杂志, 2004, 12(5):284-286.
28. 邹勇. 肝脏自然杀伤细胞在病毒诱导的肝衰竭中的作用. 华中科技大学博士学位论文, 2009.
29. 王艳海. 慢性乙型肝炎患者外周血NK细胞表达研究. 疾病监测与控制杂志, 2012, 6(10):582-584.
30. 高恒. 分泌型TRAIL基因修饰人脂肪干细胞靶向脑胶质瘤治疗的研究. 苏州大学博士论文, 2013.
31. 高远, 阮柏, 张卓, 等. 抑癌基因Tg737下调对肝癌细胞增殖的影响及其机制. 中华肝胆外科杂志, 2014, 20(12):848-851.
32. 党立力. Tg737基因在胎肝干细胞分化过程中的作用及机制研究. 第四军医大学硕士学位论文, 2014.
33. 党立力, 黄启科, 周亮, 等, T9737基因参与胎肝干细胞正常分化的机制研究. 肝胆外科杂志, 2014, 22(1):55-58.
34. You N, Liu W, Zhong X, et al. Tg737 inhibition results in malignant transformation in fetal liver stem/progenitor cells by promoting cell-cycle progression and differentiation arrest. Mol Carcinog, 2012, 51(8):659-673.
35. 王雪. MicroRNA介导间充质干细胞向肝细胞转分化的研究. 第四军医大学硕士学位论文, 2014.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Research Progress on Related Gene of Stem Cell Therapy for Acute-on-Chronic Liver Failure

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content