LI Ruimin 1,2 , XU Weihan 1 , JIN Jianmin 1 , ZHANG Yongxiang 2 , SUN Yongchang 1 Δ
  • 1. Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P. R. China;
  • 2. Department of Respiratory Medicine, Beijing Daxing Teaching Hospital, Capital Medical University, Beijing 102600, P. R. China;
SUN Yongchang, Email: suny@bjmu.edu.cn
Asthma; Chronic obstructive pulmonary disease; Asthma-COPD overlap syndrome
10.7507/1671-6205.201705034
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Objective  To study the clinical application of the GOLD/GINA criteria and the Spanish guideline in the diagnosis of asthma-COPD overlap syndrome (ACOS). Methods  Patients with stable COPD were consecutively enrolled in the study. Clinical data were collected, lung function with bronchodilator test and peak expiratory flow (PEF) were performed, and peripheral blood eosinophils, total IgE, and sputum inflammatory cells were measured. Those overlap with asthma were identified by the 2 different criteria, and the prevalence and features of ACOS were compared. Results  Among 104 cases of stable COPD, 24 (23.1%) and 10 (9.6%) were identified as ACOS by the GOLD/GINA criteria and the Spanish guideline, respectively; the latter 10 cases were all included in the former 24. For the GOLD/GINA criteria, the most common features were symptoms triggered by exercise or emotions, variable airflow limitation, family history of asthma, and other allergic conditions. Mean diurnal PEF variation≥10% was evident in 11 cases (45.8%, 11/24), while bronchodilator test was positive in 16 cases (66.7%, 16/24). For the Spanish guideline, the most common features were diagnosis of asthma before 40, other allergic diseases, positive bronchodilator test on 2 occasions. Conclusions  The GOLD/GINA criteria may be more sensitive for the diagnosis of ACOS, and do not need sophisticated lab tests, which may be more applicable for clinical use. The Spanish guideline is restrictive, and therefore may lead to under-diagnosis.

Citation： LI Ruimin, XU Weihan, JIN Jianmin, ZHANG Yongxiang, SUN Yongchang. A preliminary study on the diagnosis of asthma-COPD overlap syndrome by different criteria. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(6): 557-560. doi: 10.7507/1671-6205.201705034 Copy

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