TANG Wei 1 , ZHOU Jun 1 , GAO Xiwen 2 , ZHANG Yajuan 2 , XUE Min 2 , JIE Zhijun 3 , HANG Jingqing 4 , YU Feng 4 , LU Liwen 5 , SONG Ruihong 5 , DUAN Yuxiang 6 , JIN Xiaoyan 6 , CHENG Qijian 7 , CAI Xiaoting 7 , LUO Jianfeng 8 , QU Jieming 1
  • 1. Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University Medical College, Shanghai 200025, P. R. China;
  • 2. Department of Respiratory and Critical Care Medicine, Fudan University Affiliated Minhang Hospital, Shanghai 201199, P. R. China;
  • 3. Department of Respiratory and Critical Care Medicine, Shanghai Fifth People's Hospital Affiliated with Fudan University, Shanghai 200240, P. R. China;
  • 4. Department of Respiratory Medicine, Shanghai Putuo District People's Hospital, Shanghai 200060, P. R. China;
  • 5. Department of Respiratory Medicine, Shanghai Fengxian District Central Hospital, Shanghai 201499, P. R. China;
  • 6. Department of Respiratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, P. R. China;
  • 7. Department of Respiratory Medicine, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P. R. China;
  • 8. Institute of Biostatistics, School of Public Health, Fudan University, Shanghai 200032, P. R. China;
QU Jieming, Email: jmqu0906@163.com
Qingfei Yihuo capsule; Bronchiectasis; Acute exacerbation
10.7507/1671-6205.201810005
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Objective To evaluate the combination efficacy with Qingfei Yihuo capsule and routine antibiotics as well as mucopolytic agents in the treatment of bronchiectasis acute exacerbation.Methods This was a prospective, multi-center, randomized controlled clinical study. The efficacy of Qingfei Yihuo capsule combine with routine antibiotics and mucopolytic agents in the treatment of bronchiectasis acute exacerbation was compared according to the symptom control as well as exacerbation duration. Through randomization, patients received Qingfei Yihuo capsule or placebo combine with routine antibiotics and mucopolytic agents treatment for 10 days. Symptom score of cough, sputum, short of breath pre- and post-treatment as well as the symptom score in daily card were compared between the two groups. The spirometry and St. George respiratory questionnaire (SGRQ) before and after treatment were compared.Results This study was conducted from June 2017 to August 2018. One hundred and ninety patients from 7 centers in 6 hospitals with bronchiectasis acute exacerbation were enrolled in the study. There was statistically improvement of symptom score (including the 9th and 10th treatment days) according to the daily card recording in Qingfei Yihuo capsule group compared to the placebo group, but no statistically significant difference was found in spirometry results or SGRQ.Conclusion Qingfei Yihuo capsule has assistant effect on improving respiratory symptoms of bronchiectasis exacerbation.

Citation： TANG Wei, ZHOU Jun, GAO Xiwen, ZHANG Yajuan, XUE Min, JIE Zhijun, HANG Jingqing, YU Feng, LU Liwen, SONG Ruihong, DUAN Yuxiang, JIN Xiaoyan, CHENG Qijian, CAI Xiaoting, LUO Jianfeng, QU Jieming. Combination treatment of Qingfei Yihuo capsules in brochiectasis exacerbation: a multi-center randomized controlled clinical trial. Chinese Journal of Respiratory and Critical Care Medicine, 2019, 18(4): 352-356. doi: 10.7507/1671-6205.201810005 Copy

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