Objective To probe into the significance of tuftsin in patients with liver cancer. MethodsThe serum tuftsin level of 12 patients with liver cancer before and after the resection，20 cirrhostic and 20 normal controls were measured by radioimmunoassay (RIA). ResultsTuftsin level in preoperative group （449±106） ng/ml was much lower than that in postoperative group (588±129) ng/ml，cirrhotics group (580±187) ng/ml and control group (703±128) ng/ml (P＜0.01). The tuftsin level in postoperative group was also quite lower than that in control group (P＜0.01). Conclusion We should try our best to excise the liver cancer so that a higher tuftsin level might be obtained which can activate NK cell and T cell.
Citation：
SUN Xuejun,HUANG Fengrui,CHU Haibo,et al. Clinical Significance of Serum Tuftsin Level in Patients with Liver Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 103-104. doi:
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- 1. Najjar VA, Nishioka K. Tuftsin: A natural phagocytosisstimulating peptide [J]. Nature, 1970; 228(5)∶672.
- 2. Chu DZ, Nishioka K. Effects of tuftsin on postsplenectomy sepsis [J]. Surgery, 1985; 97(7)∶701.
- 3. Baker C, Gaines H, NivenFairchild A. The effect of tuftsin and splenectomy on mortality after intraabdominal sepsis [J]. J Surg Res, 1984; 36(3)∶499.
- 4. Noyes R, Babcock G, Nishioda K. Antitumor activity of tuftsin on murine melanoma in vivo [J]. Cancer Treatment Reports, 1981; 65(5)∶ 673.
- 5. 高平,李振甲,褚海波,等. Tuftsin放射免疫分析方法的建立和初步应用研究 [J]. 中国免疫学杂志, 1996; 12(3)∶183.
- 6. Nishioka K. Tuftsin, a hormone like tetrapeptide with antimicrobial and antitumor activities [J]. Life Sci, 1981; 28∶1081.
- 7. 顾琴龙.脾脏的白细胞激活因子“Tuftsin”的抗肿瘤作用 [J]. 蚌埠医学院学报, 1988; 13(2)∶140.
- 8. 陈辉树,陈文杰主编.脾肿大的病理与临床 [M]. 第 1版.北京: 北京医科大学、中国协和医科大学联合出版社,1998∶18~19.
- 9. 朱正纲,林言缄,尹浩然.胃癌宿主脾脏免疫状态对扩大根治术的影响 [J]. 中国肿瘤临床, 1994; 21(5)∶387.
- 10. 朱正纲,林言缄,尹浩然,等.进展期胃癌患者脾脏的免疫状态及手术治疗的研究 [J].中华医学杂志, 1992; 72(6)∶330.
