Objective To probe into disorder of plasma lipids and apolipoproteins in patients with gallstone,and their position and function in formation of gallstone. MethodsConcentration of plasma lipids and apolipoproteins in 94 healthy subjects and 161 patients with gallstones was investigated. ResultsThe gallstone group had a higher serum mean concentration of TG,Apo CⅡ,Apo CⅢ, and had a lower serum mean concentration of TC，HDLc，HDL2c，HDL3c and LDLc as compared with the control group (P＜0.01 or P＜0.05). Conclusion Higher serum mean concentration of TG，Apo CⅡ，Apo CⅢ, and lower serum mean concentration of TC, HDLc, HDL2c, HDL3c and LDLc, are characteristic of lipids metabolism and important cause of formation of gallstone.
Citation：
YAO Yougui,LI Ning,LIN Qiyuan,et al. A Study on Serum Lipids and Apolipoprotein in Patients with Gallstone. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(3): 186-188. doi:
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付贤波，宫轲，邵晓明，等. 血清脂质、载脂蛋白与胆汁类脂水平及胆囊结石类型的关系 \[J\]. 中华医学杂志，1995;75(11)∶656.
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Gylling H, Kontula K, Miettinen TA,et al. Cholesterol absorption and metabolism and LDL kinetics in healthy men with different apolipoprotein E phenotypes and apolipoprotein B Xba I and LDL receptor Pvu II genotypes [J]. Arterioscler Thromb Vasc Biol，1995; 15（2）∶208.
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- 1. Mohr GC, KritzSilverstein D,BarrettConnor E. Plasma lipids and gallbladder disease [J]. Am J Epidemiol，1991; 134(1)∶78.
- 2. Admirand WH. The physicochemical basis of cholesterol gallstone formation in man [J]. J Clin Invest，1968; 17(5)∶1043.
- 3. Harvey RRC. Will the real cholesterolnucleating and antinucleating proteins please stand up [J]? Gastroenterology，1993; 104(4)∶646.
- 4. Breslow JL. Apolipoprotein genetic variation and human disease \[M\]. Physiol Rev，1988∶68-85.
- 5. Zannis VI，Breslow JL. Genetic mutations affecting human lipoprotein metabolism [J]. Adv Hum Genet，1985; 14（1）∶125.
- 6. Alvaro D, Angelico F, Attili AF, et al. Plasma lipid lipoproteins and biliary lipid composition in female gallstone patients [J]. Biomed Biochem Acta，1986; 45（5）∶761.
- 7. Thijs C, Knipschild P, Brombacher P, et al. Serum lipids and gallstones, a casecontrol study [J]. Gastroenterology，1990; 99（6）∶843.
- 8. Hoeg JM, Meng MS, Ronan R, et al. Human apolipoprotein AI [J]. J Biochem，1986; 261（8）∶3911.
- 9. Mahley RW, Innerarity TL, Rall SC, et al. Plasma lipoproteins:apolipoprotein structure and function [J]. J Lipid Res，1984; 25（11）∶1277.
- 10. Kibe A, Holzbach RT, LaRusso NT, et al. Inhibition of cholesterol crytal formation by apolipoprotein AI and AII in model systems of supersaturated bile: implication a for gallstones pathogenesis in man [J]. Science，1984; 225（3）∶514.
- 11. Bravo E. Hepatic uptake and processing of free cholesterol from different lipoproteins with and without sodium taurocholate administration, an in vivo study in the rat [J]. Biolchem Biophys Acta，1990; 74（5）∶1045.
- 12. 付贤波，宫轲，邵晓明，等. 血清脂质、载脂蛋白与胆汁类脂水平及胆囊结石类型的关系 \[J\]. 中华医学杂志，1995;75(11)∶656.
- 13. Gylling H, Kontula K, Miettinen TA,et al. Cholesterol absorption and metabolism and LDL kinetics in healthy men with different apolipoprotein E phenotypes and apolipoprotein B Xba I and LDL receptor Pvu II genotypes [J]. Arterioscler Thromb Vasc Biol，1995; 15（2）∶208.
