VASOACTIVE MEDIATORS AND LOCAL MICROCIRCULATORY DISTURBANCE IN ACUTE PANCREATITIS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepato-Bilio-Pancreatic Surgery, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

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Keywords：

Acute pancreatitis Vasoactive mediators Microcirculatory impairment

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【Abstract】Objective To summarize the effects of vasoactive mediators on local microvasculature in acute pancreatitis（AP）. Methods Literatures concerning metabolism, receptors, action mechanisms of vasoactive mediators and their effects in AP were reviewed. Results Bradykinin, endothelin, platelet activating factor and nitric oxide were important mediators in the development of microcirculatory disturbance in AP, however the results of experiments were inconsistent. Conclusion The roles which vasoactive mediators play in microcirculatory disturbance of AP are affected by many factors, and await further study.

Citation： CHEN Youdai,GAO Hongkai,ZHOU Zongguang.. VASOACTIVE MEDIATORS AND LOCAL MICROCIRCULATORY DISTURBANCE IN ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(6): 422-424. doi: Copy

1.	Doctrow SR, Aberlleira SM, Curry LA, et al. The bradykinin analog RMP7 increases intracellular free calcium levels in rat brain microvascular endothelial cells 〔Ｊ〕. J Pharmacol Exp Ther, 1994; 274(1)∶ 229.
2.	Bloechle C, Kusterer K, Kuehn RM, et al. Inhibition of bradykinin B2 receptor preserves microcirculation in experimental pancreatitis in rats 〔Ｊ〕. Am J Physiol, 1998; 274(1 Pt 1)∶ G42.
3.	Shibuya K, Sunamura M, Yamauchi J, et al. Analysis of the derangement of the pancreatic microcirculation in a rat caerulein pancreatitis model using an intravital microscope system 〔Ｊ〕. Tohoko J Exp Med, 1996; 180(2)∶ 173.
4.	Weidenbach H, Lerch MM, Gress TM, et al. Vasoactive mediators and the progression from oedematous to necrotising experimental acute pancreatitis 〔Ｊ〕.Gut, 1995; 37(3)∶ 434.
5.	Sun DX(孙篤新), Rui YC, Zeng GQ, et al. Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs 〔Ｊ〕. 中国药理学报，1992; 13(4)∶ 326.
6.	Flickinger BD, Olson MS. Localization of the plateletactivating factor receptor to rat pancreatic microvascular endothelial cells 〔Ｊ〕. Am J Pathol, 1999; 154(5)∶1353.
7.	Wang X, Sun Z, Borjesson A, et al. Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis 〔Ｊ〕.Int J Pancreatol, 1999; 25(1)∶ 45.
8.	Foitzik T, Hotz HG, Eibl G, et al. Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of plateletactivating factor receptor blockade vs. Endothelin receptor blockade 〔Ｊ〕.J Gastrointest Surg, 1999; 3(3)∶ 244.
9.	Liu XH, Kimura T, Ishikawa H, et al. Effect of endothelin1 on the development of hemorrhagic pancreatitis in rats 〔Ｊ〕. Scand J Gastroenterol, 1995; 30(3)∶276.
10.	Plusczyk T, Bersal B, Westermann S, et al. ET1 induces pancreatitislike microvascular deterioration and acinar cell injury 〔Ｊ〕.J Surg Res, 1999; 85(2)∶ 301.
11.	Chen HM, Shyr MH, Lau YT, et al. Leukocyteendothelial adherence correlates with pancreatic nitric oxide production in early ceruleininduced pancreatitis in rats 〔Ｊ〕. Shock, 1998; 10(3)∶ 218.
12.	Inagaki H, Nakao A, Kurokawa T, et al. Neutrophil behavior in pancreas and liver and the role of nitric oxide in rat acute pancreatitis 〔Ｊ〕. Pancreas, 1997;15(3)∶ 304.
13.	Dobosz M, Wajda Z, Hac S, et al. Nitric oxide, heparin and procaine treatment in experimental ceruleineinduced acute pancreatitis in rats 〔Ｊ〕. Arch Immunol Ther Exp, 1999; 47(3)∶ 155.
14.	Bull HA, Hothersall J, Chowdhury N, et al. Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells 〔Ｊ〕. J Invest Dermatol, 1996; 106(4)∶ 655.
15.	Grady EF, Yoshimi SR, Iaa J, et al. Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin1 receptor in rats and mice 〔Ｊ〕.Br J Pharmacol, 2000; 130(3)∶ 505.
16.	Bhatia I, Saluja AK, Hofbauer B, et al. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitisassociated lung injury 〔Ｊ〕. Proc Natl Acad Sci USA, 1998; 95(8)∶ 4760.
17.	Foitzik T, Eibl G, Buhr HJ. Therapy for microcirculatory disorders in severe acute pancreatitis: comparison of delayed therapy with ICAM1 antibodies and a specific endothelin a receptor antagonist 〔Ｊ〕. J Gastrointest Surg, 2000; 4(3)∶ 240.
18.	Frossard JL, Saluja A, Bhagat L, et al. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitisassociated lung injury 〔Ｊ〕. Gastroenterology, 1999;116(3)∶ 694.

1. Doctrow SR, Aberlleira SM, Curry LA, et al. The bradykinin analog RMP7 increases intracellular free calcium levels in rat brain microvascular endothelial cells 〔Ｊ〕. J Pharmacol Exp Ther, 1994; 274(1)∶ 229.
2. Bloechle C, Kusterer K, Kuehn RM, et al. Inhibition of bradykinin B2 receptor preserves microcirculation in experimental pancreatitis in rats 〔Ｊ〕. Am J Physiol, 1998; 274(1 Pt 1)∶ G42.
3. Shibuya K, Sunamura M, Yamauchi J, et al. Analysis of the derangement of the pancreatic microcirculation in a rat caerulein pancreatitis model using an intravital microscope system 〔Ｊ〕. Tohoko J Exp Med, 1996; 180(2)∶ 173.
4. Weidenbach H, Lerch MM, Gress TM, et al. Vasoactive mediators and the progression from oedematous to necrotising experimental acute pancreatitis 〔Ｊ〕.Gut, 1995; 37(3)∶ 434.
5. Sun DX(孙篤新), Rui YC, Zeng GQ, et al. Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs 〔Ｊ〕. 中国药理学报，1992; 13(4)∶ 326.
6. Flickinger BD, Olson MS. Localization of the plateletactivating factor receptor to rat pancreatic microvascular endothelial cells 〔Ｊ〕. Am J Pathol, 1999; 154(5)∶1353.
7. Wang X, Sun Z, Borjesson A, et al. Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis 〔Ｊ〕.Int J Pancreatol, 1999; 25(1)∶ 45.
8. Foitzik T, Hotz HG, Eibl G, et al. Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of plateletactivating factor receptor blockade vs. Endothelin receptor blockade 〔Ｊ〕.J Gastrointest Surg, 1999; 3(3)∶ 244.
9. Liu XH, Kimura T, Ishikawa H, et al. Effect of endothelin1 on the development of hemorrhagic pancreatitis in rats 〔Ｊ〕. Scand J Gastroenterol, 1995; 30(3)∶276.
10. Plusczyk T, Bersal B, Westermann S, et al. ET1 induces pancreatitislike microvascular deterioration and acinar cell injury 〔Ｊ〕.J Surg Res, 1999; 85(2)∶ 301.
11. Chen HM, Shyr MH, Lau YT, et al. Leukocyteendothelial adherence correlates with pancreatic nitric oxide production in early ceruleininduced pancreatitis in rats 〔Ｊ〕. Shock, 1998; 10(3)∶ 218.
12. Inagaki H, Nakao A, Kurokawa T, et al. Neutrophil behavior in pancreas and liver and the role of nitric oxide in rat acute pancreatitis 〔Ｊ〕. Pancreas, 1997;15(3)∶ 304.
13. Dobosz M, Wajda Z, Hac S, et al. Nitric oxide, heparin and procaine treatment in experimental ceruleineinduced acute pancreatitis in rats 〔Ｊ〕. Arch Immunol Ther Exp, 1999; 47(3)∶ 155.
14. Bull HA, Hothersall J, Chowdhury N, et al. Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells 〔Ｊ〕. J Invest Dermatol, 1996; 106(4)∶ 655.
15. Grady EF, Yoshimi SR, Iaa J, et al. Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin1 receptor in rats and mice 〔Ｊ〕.Br J Pharmacol, 2000; 130(3)∶ 505.
16. Bhatia I, Saluja AK, Hofbauer B, et al. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitisassociated lung injury 〔Ｊ〕. Proc Natl Acad Sci USA, 1998; 95(8)∶ 4760.
17. Foitzik T, Eibl G, Buhr HJ. Therapy for microcirculatory disorders in severe acute pancreatitis: comparison of delayed therapy with ICAM1 antibodies and a specific endothelin a receptor antagonist 〔Ｊ〕. J Gastrointest Surg, 2000; 4(3)∶ 240.
18. Frossard JL, Saluja A, Bhagat L, et al. The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitisassociated lung injury 〔Ｊ〕. Gastroenterology, 1999;116(3)∶ 694.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

VASOACTIVE MEDIATORS AND LOCAL MICROCIRCULATORY DISTURBANCE IN ACUTE PANCREATITIS

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