To evaluatae the role of cathepsin B in the pathogenesis of acute pancreatitis. The experimental dogs were divided into three groups based on the severity. An acute edematous pancreatitis group (n＝11), an acute hemorrhagic necrotizing pancreatitis group (n＝12), and a control group (n＝7). Distribution of cathepsin B in pancreatic aciner cell was studied. Results: there was a redistribution of cathepsin B from the lysosomal fraction to the zymogen fraction. The results indicated that cathepsin B play a important role in the pathoagenesis of acute pancreatitis.
Citation：
Wang Maoxu,Liu Houdong,Zeng Rong,et al.. THE ROLE OF CATHEPSIN B IN THE PATHOGENESIS OF ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(6): 338-339. doi:
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- 1. Mc Donald JK, Ellis. In the substrate specificity of cathepsin B1 and B2 including a new flurogonic substrate for cathepsin B1. Life Sci, 1975; 17∶1269.
- 2. Lombardi B, Estes LW, Longnecker DS. Acute hemorrhagic pancreatitis (cmassive necrosis) with fat necrosis induced in mice by dlehionine fed with a cholinedeficient diet. Am J Pathol, 1975; 79∶465.
- 3. Bialek R, Willemer S, Arnold R, et al. Evidence of intracellular activation of serumproteases in acute ceruleininduced pancreatitis in rats. Scand J Gastroenterol, 1991; 26∶130.
- 4. Ohshio G, Saluja A, Steer ML. Effects of shortterm pancreatic duct obstruction in rats. Gastroenterology, 1991; 199∶196.
- 5. Steer ML. Pathognesis of acute pancreatitis. Ann Rev Med, 1988; 39∶95.
- 6. Hirano T, Manake T, Yotsumoto F, et al. Effect of prostaglandin E on the restistribution of lysosomal enzyme in ceruleininduced pancreatitis. Hepatogastroenterology, 1993; 40∶155.
