支气管哮喘防治全球创议(GINA)将哮喘的严重程度分为三度四级，其中三级和四级属于中度和重度哮喘。在整个哮喘人群当中，中重度哮喘大约只占1／3，但在临床上轻度哮喘患者很少就诊，中重度哮喘大约占就诊患者的2／3甚至更多。中重度哮喘患者由于症状明显，频繁就诊，因为哮喘控制不良，经常出现急性发作，需要住院治疗，虽然人数不是很多，但占用了大部分的医疗资源。无论是从提高哮喘防治的整体水平的角度，还是从减少哮喘疾病负担的角度，都应当将中重度哮喘作为哮喘长期管理的主要的目标人群。
Citation：
LIU Chuntao. Therapy adjustment for moderate and severe asthma. Chinese Journal of Respiratory and Critical Care Medicine, 2007, 6(5): 329-331. doi:
Copy
Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
| 1. |
National institutes of health，National heart，Lung and Blood Institute.Global strategy for asthma management and prevention.Revised，2006，http：//www.ginasthma.com/ Guidelineitem.asp.
|
| 2. |
Bateman ED，Boushey HA，Bousquet J，et al.Can guideline-defined asthma control be achieved?The Gaining Optimal Asthma ControL study.Am J Respir Crit Care Med，2004，170：836-844.
|
| 3. |
van den Toorn LM，Overbeek SE，de Jongste JC，et al.Airway inflammation is present during clinical remission of atopic asthma.Am J Respir Crit Care Med，2001，164：2107-2113.
|
| 4. |
Bateman ED，Jacques L，Goldfrad C，et al.Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down.J Allergy Clin Immunol，2006，117：563-570.
|
| 5. |
Woolcock AJ，Jenkins CR.Assessment of bronchial responsiveness as a guide to prognosis and therapy in asthma.Med Clin North Am，1990，74：753-765.
|
| 6. |
Rabe KF，Atienza T，Magyar P，et al.Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations：a randomised controlled，double-blind study.Lancet，2006，368：744-753.
|
- 1. National institutes of health，National heart，Lung and Blood Institute.Global strategy for asthma management and prevention.Revised，2006，http：//www.ginasthma.com/ Guidelineitem.asp.
- 2. Bateman ED，Boushey HA，Bousquet J，et al.Can guideline-defined asthma control be achieved?The Gaining Optimal Asthma ControL study.Am J Respir Crit Care Med，2004，170：836-844.
- 3. van den Toorn LM，Overbeek SE，de Jongste JC，et al.Airway inflammation is present during clinical remission of atopic asthma.Am J Respir Crit Care Med，2001，164：2107-2113.
- 4. Bateman ED，Jacques L，Goldfrad C，et al.Asthma control can be maintained when fluticasone propionate/salmeterol in a single inhaler is stepped down.J Allergy Clin Immunol，2006，117：563-570.
- 5. Woolcock AJ，Jenkins CR.Assessment of bronchial responsiveness as a guide to prognosis and therapy in asthma.Med Clin North Am，1990，74：753-765.
- 6. Rabe KF，Atienza T，Magyar P，et al.Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations：a randomised controlled，double-blind study.Lancet，2006，368：744-753.
