Obstractive To observe the clinical effects and safety of endobronchial electrocautery treatment for tracheobronchial obstructive lesions in inoperable tracheobronchial squamous cell carcinoma.Methods Ninety-five patients with advanced and inoperable tracheobronchial squamous cell carcinoma were included. Thirty-four patients with central airway obstruction were treated with endobronchial electrocautery plus chemotherapy ( group A) and 61 patients without central airway obstruction were treated with chemotherapy alone ( group B) . The chemotherapy consisted of cisplatin or carboplatin, plus another thirdgeneration chemotherapy agent. Results In groug A, there were mean improvements in FEV1 of 41. 1% and in peak expiratory flow( PEF) of 65. 6% . There was no significant difference in the survival rates of the patients with and without central airway obstruction. Median survival time of group A was 11. 3 months and those of group B was 11. 6 months. 3, 6, and 12-month survival rates in group A were 87% , 68% and 39% respectively, and those in group B were 93% , 76% , and 45% respectively. Conclusion Endobronchial electrocautery is an effective and safe approach for inoperable tracheobronchial obstructive malignancies with few complications.
Citation：
YE Jun,SHI Zhaoquan,LI Bing,XIU Qingyu. Endobronchial Electrocautery Treatment of Tracheobronchial Obstructive Lesions in Inoperable Tracheobronchial Squamous Cell Carcinoma. Chinese Journal of Respiratory and Critical Care Medicine, 2009, 09(6): 572-574. doi:
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Waechter F, Passweg J, Tamm M, et al. Significant progress in palliative treatment of non-small cell lung cancer in the past decade. Chest, 2005, 127: 738-747.
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van Boxem AJ, Westerga J, Venmans BJ, et al. Photodynamic therapy, Nd-YAG laser and electrocautery for treating early-stage intraluminal cancer: Which to choose? Lung Cancer, 2001, 31: 31-36.
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Boxem T, Muller M, Venmans B, et al. Nd-YAG laser vs bronchoscopic electrocautery for palliation of symptomatic airway obstruction: A cost-effectiveness study. Chest,1999, 116: 1108-1112.
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Coulter TD, Mehta AC. The heat is on: Impact of endobronchial electrosurgery on the need for Nd-YAG laser photoresection. Chest,2000, 118: 516-521.
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Sutedja G, van Kralingen K, Schramel F, et al. Fiberoptic bronchoscopy electrosurgery under local anesthesia for rapid palliation in patients with central airway malignancies: a preliminary report. Thorax, 1994, 49: 1243-1246.
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王辰飞, 李强, 白冲, 等. 支气管镜下腔内高频电刀治疗中央气道良、恶性肿瘤的临床疗效. 第二军医大学学报, 2007, 28: 554-556.
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| 10. |
Colt HG, Harrell JH. Therapeutic rigid bronchoscopy allows level of care changes in patients with acute respiratory failure from central airways obstruction. Chest, 1997, 112: 202-206.
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- 1. Waechter F, Passweg J, Tamm M, et al. Significant progress in palliative treatment of non-small cell lung cancer in the past decade. Chest, 2005, 127: 738-747.
- 2. Santos RS, Raftopoulos Y, Keenan RJ, et al. Bronchoscopic palliation of primary lung cancer: single or multimodality therapy?Surg Endosc , 2004, 18: 931-936.
- 3. Vonk-Noordegraaf A, Postmus PE, Sutedja TG. Tracheobronchial stenting in the terminal care of cancer patients with central airways obstruction. Chest, 2001, 120: 1811-1814.
- 4. Bolliger CT, Mathur PN, Beamis JF, et al. ERS/ATS statement on interventional pulmonology. European Respiratory Society /American Thoracic Society . Eur Respir J, 2002, 19: 356-373.
- 5. van Boxem AJ, Westerga J, Venmans BJ, et al. Photodynamic therapy, Nd-YAG laser and electrocautery for treating early-stage intraluminal cancer: Which to choose? Lung Cancer, 2001, 31: 31-36.
- 6. Boxem T, Muller M, Venmans B, et al. Nd-YAG laser vs bronchoscopic electrocautery for palliation of symptomatic airway obstruction: A cost-effectiveness study. Chest,1999, 116: 1108-1112.
- 7. Coulter TD, Mehta AC. The heat is on: Impact of endobronchial electrosurgery on the need for Nd-YAG laser photoresection. Chest,2000, 118: 516-521.
- 8. Sutedja G, van Kralingen K, Schramel F, et al. Fiberoptic bronchoscopy electrosurgery under local anesthesia for rapid palliation in patients with central airway malignancies: a preliminary report. Thorax, 1994, 49: 1243-1246.
- 9. 王辰飞, 李强, 白冲, 等. 支气管镜下腔内高频电刀治疗中央气道良、恶性肿瘤的临床疗效. 第二军医大学学报, 2007, 28: 554-556.
- 10. Colt HG, Harrell JH. Therapeutic rigid bronchoscopy allows level of care changes in patients with acute respiratory failure from central airways obstruction. Chest, 1997, 112: 202-206.
