Objective To explore the effects of propofol and thiopental sodium injection on convulsive seizure in electro-convulsive therapy(ECT) and to provide evidence to help the selection of intravenous anaesthetics in improved ECT.
Methods Total of 111 patients who received ECT in the 3rd Pepole’s Hospital of Panzhihua from July to December 2005 were divided into a thiopental sodium group (n =62) and a propofol group (n =49). These patients received intravenous anaesthesia with suxamethonium plus thiopental sodium or propofol for the implementation of ECT, respectively. The status of convulsive seizure was compared between the two groups.
Results There were no significant differences between the two groups in terms of main demographic data, disease category and ECT parameters (P gt;0.05). Motor seizure and electricity discharge lasted significantly longer in the propofol group than in the thiopental sodium group (P lt;0.01).
Conclusion Thiopental sodium can increase the excitation threshold of brain cortical neurons and decrease the level of convulsive seizure induced by ECT. Propofol may decrease the excitation threshold, and increase the level of convulsive seizure under the same ECT parameters, but may have the potential to induce epileptic seizure.
Citation：
LIU Shaobin,YIN Jixu,ZHU Xinyu. A Comparison of the Effects of Propofol and Thiopental on Convulsive Seizure During Electro-convulsive Therapy. Chinese Journal of Evidence-Based Medicine, 2006, 06(11): 786-789. doi:
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
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- 2. 江开达. 主编. 精神病学. 第1版. 北京:人民卫生出版社; 2005. 292.
- 3. 吴在德. 主编. 外科学. 第5版. 北京: 人民卫生出版社; 2002. 226~227.
- 4. 许律西, 张蔚良, 沈其杰. 无抽搐电休克对特殊患者群体的治疗现状. 中华精神科杂志, 2006; 39(3): 190.
- 5. 陈学诗. 主编. 现代精神疾病治疗学. 第1版. 山东: 山东科学技术出版社; 1997. 324.
- 6. 刘俊杰, 赵俊. 主编. 现代麻醉学. 第1版. 北京: 人民卫生出版社; 1995. 173.
- 7. 徐启明. 主编. 临床麻醉学. 第2版. 北京: 人民卫生出版社; 2005. 88.
- 8. Shen YT. Psychiatry. 3rd edition. Beijing: People’s Medical Publishing House; 1997. 974, 1007–1010.
- 9. Jiang KD. Psychiatry. 1st edition. Beijing: People’s Medical Publishing House; 2005. 292.
- 10. Wu ZD. Surgery. 5th edition. Beijing: People’s Medical Publishing House; 2002. 226–227.
- 11. Xu LX, Zhang WL, Shen QJ. The status quo of MECT in special patient populations. Chinese Journal of Psychiatry, 2006; 39(3): 190.
- 12. Flaishon R, Sebel PS, Sigl J. Bispectral analysis of the EEG for monitoring the hypnotic effect of propofol and propofol/alfentanil. Anesthesiology, 1995; 83(3A): A514–515.
- 13. Leslie K, Sessler DI, Smith WD, et al. Prediction of movement during propofol/nitrous oxide anesthesia. Anesthesiology, 1996; 84: 52–63.
- 14. Chen XS. Modern Psychiatrical Treatment. 1st edition. Shandong: Shandong Science & Technology Publishing House; 1997. 324.
- 15. Liu JJ, Zhao J. Modern Anesthesiology. 1st edition. Beijing: People’s Medical Publishing House; 1995. 173.
- 16. Xu QM. Clinical Anesthesiology. 2nd edition. Beijing: People’s Medical Publishing House; 2005. 88.
