Objective To investigate the expression of tumor suppressor gene Lumican mRNA in gastric cancer and its role in the development of gastric cancer.
Methods The expressions of Lumican mRNA in gastric cancer tissues, tissues near tumor and normal tissues were detected by using reverse transcription polymerase chain reaction (RT-PCR), clinical pathology for those tissues was studied as well.
Results The expression absence rates of Lumican mRNA were 42.4% (28/66), 15.2% (10/66) and 0 in gastric cancer tissues, tissues near tumor and normal tissues respectively. The expression absence rate of Lumican mRNA in patients with lymph node metastasis was 61.1%, which was significantly higher than that of the patients without lymph node metastasis (20.0%, χ2=11.323, P=0.001). The expression absence rate of Lumican mRNA in the gastric cancer at the advanced stages (stages Ⅲ, Ⅳ) was 61.5%, which was significantly higher than that in the gastric cancer at the early stages (stages Ⅰ, Ⅱ, 30.0%, χ2=6.417， P=0.011). The expression absence rates of Lumican mRNA in the high, moderate and poor differentiation tumors were 38.5% (10/26), 38.5% (10/26) and 57.1% (8/14) respectively, the expression absence rate of Lumican mRNA was no significant association with the differentiation degree (χ2=1.576, P=0.455).
Conclusion The expression absence of tumor suppressor gene Lumican mRNA may play an important role in the tumorgenesis and influences the prognosis of gastric cancer.
Citation：
LUO Hairong,LIU Lianxin,JIANG Hongchi. Expression of Lumican mRNA in Gastric Cancer and Its Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2007, 14(5): 551-553. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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文亚渊， 刘宝华， 洪胜龙， 等. 凋亡相关基因survivin、 caspase-3及cyclin-B1在胃癌发生、 发展中的作用 [Ｊ]. 中国普外基础与临床杂志， 2006； 13（1）∶34.
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Chakravarti S, Stallings RL, SundarRaj N, et al. Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22 [Ｊ]. Genomics, 1995; 27(3)∶481.
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Leygue E, Snell L, Dotzlaw H, et al. Expression of lumican in human breast carcinoma [Ｊ]. Cancer Res, 1998; 58(7)∶1348.
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Koninger J, Giese T, di Mola FF, et al. Pancreatic tumor cells influence the composition of the extracellular matrix [Ｊ]. Biochem Biophys Res Commun, 2004; 322(3)∶943.
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Lu YP, Ishiwata T, Kawahara K, et al. Expression of lumican in human colorectal cancer cells [Ｊ]. Pathol Int, 2002; 52(8)∶519.
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| 6. |
Shinji S, Tajiri T, Ishiwata T, et al. Different expression levels of lumican in human carcinoid tumor and neuroendocrine cell carcinoma [Ｊ]. Int J Oncol, 2005; 26(4)∶873.
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| 7. |
Naito Z, Ishiwata T, Kurban G, et al. Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests [Ｊ]. Int J Oncol, 2002; 20(5)∶943.
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| 8. |
Vij N, Roberts L, Joyce S, et al. Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea [Ｊ]. Exp Eye Res, 2004; 78(5)∶957.
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- 1. 文亚渊， 刘宝华， 洪胜龙， 等. 凋亡相关基因survivin、 caspase-3及cyclin-B1在胃癌发生、 发展中的作用 [Ｊ]. 中国普外基础与临床杂志， 2006； 13（1）∶34.
- 2. Chakravarti S, Stallings RL, SundarRaj N, et al. Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22 [Ｊ]. Genomics, 1995; 27(3)∶481.
- 3. Leygue E, Snell L, Dotzlaw H, et al. Expression of lumican in human breast carcinoma [Ｊ]. Cancer Res, 1998; 58(7)∶1348.
- 4. Koninger J, Giese T, di Mola FF, et al. Pancreatic tumor cells influence the composition of the extracellular matrix [Ｊ]. Biochem Biophys Res Commun, 2004; 322(3)∶943.
- 5. Lu YP, Ishiwata T, Kawahara K, et al. Expression of lumican in human colorectal cancer cells [Ｊ]. Pathol Int, 2002; 52(8)∶519.
- 6. Shinji S, Tajiri T, Ishiwata T, et al. Different expression levels of lumican in human carcinoid tumor and neuroendocrine cell carcinoma [Ｊ]. Int J Oncol, 2005; 26(4)∶873.
- 7. Naito Z, Ishiwata T, Kurban G, et al. Expression and accumulation of lumican protein in uterine cervical cancer cells at the periphery of cancer nests [Ｊ]. Int J Oncol, 2002; 20(5)∶943.
- 8. Vij N, Roberts L, Joyce S, et al. Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea [Ｊ]. Exp Eye Res, 2004; 78(5)∶957.
