Gibson等首先发现7例慢性咳嗽患者表现为慢性刺激性干咳或咳少许黏痰，诱导痰嗜酸粒细胞增高，糖皮质激素治疗效果良好；但患者肺通气功能正常，无气道高反应性 (AHR)，峰流速(PEF)变异率正常，无法诊断为支气管哮喘，因而称之为嗜酸粒细胞性支气管炎(EB)。研究结果发表于 1989年国际著名杂志柳叶刀(Lancet)。从Gibson等提出 EB的诊断以来，受到国内外广大专家的重视，虽然目前对 EB是否是一种独立的疾病或哮喘的早期阶段尚存在一些争议，但愈来愈多的证据表明EB是一种独立的疾病 。下面从EB的定义、病因、病理免疫特征、临床表现、治疗反应及预后等方面对此问题进行讨论，说明EB是一种独立的疾病。
Citation：
LAI Kefang. Eosinophilic bronchitis is a distinct entity. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(6): 412-413. doi:
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| 1. |
Gibson PG，Denburg J，Dolovich J，et al．Chronic COUgh：eosinophilic bronchitis without astIlma．Lancet，1989，1：1346．1348.
|
| 2. |
O BIightling CE．Chronic Cough Due to Nonasthmatic Eosinophilic Bron— chitis．ACCP Evidence—Based Clinical Practice Guidelines．Chest．20o6.
|
| 3. |
Thomson NC，Chaudhuri R．Why is eosinophilic bronchitis not asthma? Am J Respir Crit Care Med．2004，170：4-5.
|
| 4. |
罗炜，赖克方，陈如冲，等．嗜酸粒细胞性支气管炎气道炎症病理特征的探讨．中国病理和生理杂志，2006，22：943-947.
|
| 5. |
Niimi A ，Matsumoto H，Minakuchi M ，et al．Airway remodeling in cough—variant asthma．Lancet，2000，356：564-565.
|
| 6. |
KanazawaH，Nomura S，Yoshikawa J．Role of microvascular permeability on physiologicdifferences in asthma and eosinophilic bronchi— tis．Am J Respir Crit Care Med，2004，169：1125-1130.
|
| 7. |
Sastre B，Fern6ndez-Nieto M，Molld R，et al．Increased prostaglandin E2 levels in the airw ay of patients with eosinophilic bronchitis．Allergy，2008，63：58-66.
|
| 8. |
Brightling CE，Bradding P，Symon F，et al．Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med，2002，346：1699- 1705.
|
| 9. |
Hartney JM ，Coggins KG，Tilley SL，et al．Prostaglandin E2 protects lower airways against bronchoconstriction．Am J Physiol Lung Cell Mol Physiol，2006，290：L105一L1 13. 9 Brightling CE，Ward R，Wohmann G，et al．Induced sputum inflam— matory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med，2000，162(3 Pt 1)：878—882.
|
| 10. |
Berry MA，Hargadon B，McKenna S，et al．Observational study ofthe natural history of eosinophilic bronchitis．Clin Exp Allergy，2005， 35：598-601.
|
| 11. |
Brightling CE，Ward R，Goh KL，et al．Eosinophilic bronchitis is an important cause of chronic cough．Am J Respir Crit Care Med．1999.
|
| 12. |
：116—121.
|
| 13. |
：406-410.
|
- 1. Gibson PG，Denburg J，Dolovich J，et al．Chronic COUgh：eosinophilic bronchitis without astIlma．Lancet，1989，1：1346．1348.
- 2. O BIightling CE．Chronic Cough Due to Nonasthmatic Eosinophilic Bron— chitis．ACCP Evidence—Based Clinical Practice Guidelines．Chest．20o6.
- 3. Thomson NC，Chaudhuri R．Why is eosinophilic bronchitis not asthma? Am J Respir Crit Care Med．2004，170：4-5.
- 4. 罗炜，赖克方，陈如冲，等．嗜酸粒细胞性支气管炎气道炎症病理特征的探讨．中国病理和生理杂志，2006，22：943-947.
- 5. Niimi A ，Matsumoto H，Minakuchi M ，et al．Airway remodeling in cough—variant asthma．Lancet，2000，356：564-565.
- 6. KanazawaH，Nomura S，Yoshikawa J．Role of microvascular permeability on physiologicdifferences in asthma and eosinophilic bronchi— tis．Am J Respir Crit Care Med，2004，169：1125-1130.
- 7. Sastre B，Fern6ndez-Nieto M，Molld R，et al．Increased prostaglandin E2 levels in the airw ay of patients with eosinophilic bronchitis．Allergy，2008，63：58-66.
- 8. Brightling CE，Bradding P，Symon F，et al．Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med，2002，346：1699- 1705.
- 9. Hartney JM ，Coggins KG，Tilley SL，et al．Prostaglandin E2 protects lower airways against bronchoconstriction．Am J Physiol Lung Cell Mol Physiol，2006，290：L105一L1 13. 9 Brightling CE，Ward R，Wohmann G，et al．Induced sputum inflam— matory mediator concentrations in eosinophilic bronchitis and asthma. Am J Respir Crit Care Med，2000，162(3 Pt 1)：878—882.
- 10. Berry MA，Hargadon B，McKenna S，et al．Observational study ofthe natural history of eosinophilic bronchitis．Clin Exp Allergy，2005， 35：598-601.
- 11. Brightling CE，Ward R，Goh KL，et al．Eosinophilic bronchitis is an important cause of chronic cough．Am J Respir Crit Care Med．1999.
- 12. ：116—121.
- 13. ：406-410.
