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find Keyword "单心室" 26 results
  • The Value and Significance of Brain Natriuretic Peptide in Evaluating the Heart Function of Functional Single Ventricle after TCPC Procedure

    Objective To investigate the value and significance of the changes of plasma level of brain natriuretic peptide(BNP) in evaluating ventricle performance of functional single ventricle after total cavopulmonary connection (TCPC). Methods We studied 11 patients with functional single ventricle undergone TCPC procedure after 2.1 years, who were followed-up at our ward between April 2004 and November 2004, 7 of them were males and 4 of them were females (TCPC group). The clinical heart function of patients was scored according to the modified scoring system described by Ross. We obtained 3ml blood samples from the extremital vein of all subjects. Blood was collected into chilled tubes containing EDTA and aprotinin (4.5mg and 1 500u/ml blood, respectively). The blood samples were promptly centrifuged (-4℃, 3 000r/min for 10 min) and the plasma was separated. BNP concentration was determined using immunoradiometric assay kits. Magnetic resonance imaging (MRI) examination was undertaken in 6 patients of TCPC group to analyse the relative factors with the change of BNP. Control group included 9 healthy children. Results (1) Median plasma BNP level for TCPC group and control group was 400pg/ ml (IQR200-690) and 110 pg/ml (IQR90-190), respectively. There was a significant difference in plasma BNP between them (P=0. 003). (2) The results of the index of heart function of TCPC group determined by MRI were 65. 76±8. 65 ml/m2 in end-diastolic volume index, 31. 90±6. 36ml/m2 in end-systolic volume index, 39.09±11.76ml/m2 in stroke volume index, 0. 52± 0. 06 in ejection fraction(EF), 2.38±0.58L/min·m2 in cardiac index (CI), 103.49±21.57g/m2 in mass index and 1.57±0.24 in mass/EDV. (3) The plasma BNP level for TCPC group was significant correlation with operation ages(r=0.632, P=0.041 ). There was no correlation between plasma BNP level with EF, CI, score of Ross, gender, ages, percutaneous oxygen saturation(SpO2) and the type of dominant ventricle, respectively. Conclusions Raised concentration of plasma BNP in patients 2 years after undertaken TCPC procedure indicates that nervous-endosecretory system is still under stress condition. This pattern suggests that neurohormonal activation is primarily related to the altered postoperative physiology. the significance of BNP in patients of functional single ventricle after undertaken TCPC is different from tat in biventricular physiology patiens. The plasma BNP level could not be correctly evaluated the cardiac function after TCPC operation.

    Release date:2016-08-30 06:23 Export PDF Favorites Scan
  • Surgical Treatment for Atrioventricular Valve Regurgitation in Patients with Single Ventricle

    目的 总结单心室瓣膜反流的外科治疗经验,观察治疗效果。 方法 回顾性分析2006年7月至2012年1月上海交通大学医学院附属新华医院61例单心室患者的临床资料,其中男36例,女25例;手术年龄2个月至 20岁;体重2~58 kg。右心室型41例,左心室型13例,未定型型7例。根据瓣膜反流程度不同分为3组,无/微量反流组:28例,瓣膜未行处理;轻/中度反流组:21例,瓣膜未行处理;重度反流组:12例,手术同期行瓣膜成形。收集所有患者住院及随访资料,分析轻/中度反流组、重度反流组瓣膜反流变化趋势,以及影响瓣膜反流的因素。结果 住院死亡5例,住院死亡率8.2% (5/61)。重度反流组患者行瓣膜成形术后反流程度较术前明显减轻(由术前4.00级下降至术后2.08级)。随访56例,随访时间6~38个月,重度反流组随访10例,随访期间死亡2例,其余8例中重度反流2例,中度反流3例,轻度反流2例,微量反流1例;瓣膜反流程度增加趋势明显(由术后平均2.08级增加至平均2.75级)。轻/中度反流组随访19例,随访中无死亡,其中反流程度增加至重度3例(原1例轻度反流,2例中度反流),反流程度由轻度增加至中度3例,瓣膜反流程度由术后平均2.33级增加为平均2.58级。轻/中度反流组瓣膜反流增加率与无/轻微反流组比较差异无统计学意义(瓣膜反流增加率为31.5% vs. 19.2%,χ2=0.36,P=0.55)。单因素分析结果显示,瓣膜反流增加者在随访过程中心功能较瓣膜反流无变化或减轻者明显降低(术后左心室射血分数53.11%±5.61% vs. 59.65%±3.32%,t =-5.49,P=0.00),而左心室舒张期末容积较瓣膜反流无变化或减轻者明显增加(t =2.58,P=0.01)。 结论 单心室合并重度瓣膜反流行瓣膜成形术近期效果较好,但随着心功能下降、心室扩张,瓣膜反流程度加重趋势明显;轻/中度瓣膜反流可暂不进行处理,但部分患者瓣膜反流有增加趋势,提示应注重术后随访。

    Release date:2016-08-30 05:47 Export PDF Favorites Scan
  • Surgical management of total cavopulmonary connection procedure in functional single ventricle with separate hepatic venous drainage

    ObjectiveTo investigate the management of hepatic vein (HV) in patients with functional single ventricle (FSV) and separate hepatic venous drainage (SHVD) undergoing total cavopulmonary connection (TCPC) and evaluate this kind of surgery.MethodsThe clinical data of 32 consecutive patients with SHVD who underwent modified TCPC operation from August 2005 to January 2017 in our center were retrospectively analyzed. There were 25 males and 7 females with an average age of 2-19 (8.0±5.0) years and body weight of 11-66 (25.4±15.8) kg.ResultsThere were 20 patients with heterotaxy syndrome and 12 patients with other types of FSV. SHVD was diagnosed preoperatively in 27 patients, among whom 20 patients were connected by intra-extracardiac Gore-Tex conduit, and the other 7 patients were connected by extracardiac Gore-Tex conduit. Because of the missed diagnosis of SHVD, the other 5 patients showed severe decrease of blood oxygen saturation in the early postoperative period and underwent re-operation soon. The postoperative blood oxygen saturation was 92.0% (90.0%, 96.0%), central venous pressure was 10-23 (15.5±3.5) mm Hg, mechanical ventilation assisted time was 16.0 (7.5, 24.0) h, and ICU stay time was 3.0 (2.0, 5.5) d. There were 3 early and 1 late deaths.ConclusionIntra-extracardiac conduit is an effective and feasible modified TCPC operation for patients with FSV and SHVD, while the surgical details need to be formulated in combination with individual anatomical structure. Preoperative missed diagnosis of SHVD must be avoided. Otherwise, after TCPC, a large amount of stealing blood from HV with low circulation pressure into atrium would lead to unacceptable hypoxemia.

    Release date:2022-05-23 10:52 Export PDF Favorites Scan
  • Strategy of surgical management for pulmonary atresia with intact ventricular septum and mid-term follow-up

    ObjectiveTo evaluate the surgical strategy and follow-up for pulmonary atresia with intact ventricular septum (PA/IVS) in our heart center.MethodsFrom January 2008 to December 2018, 151 patients with PA/IVS were divided into two groups: a one-stage surgery group (26 patients), including 17 males and 9 females at an average age of 14.7±13.2 months, and a staged surgery group (125 patients) including 72 males and 53 females at an average age of 6.4±6.3 months. The clinical effectiveness of the two groups were analyzed.ResultsAll patients were followed up for 1-11 years. Eighteen patients died and 19 patients were lost to follow-up. The 1-year, 5-year and 10-year survival rate was 90.2%, 87.0%, and 85.2%, respectively. Two patients died in the one-stage surgery group. Twelve patients died after initial surgery, and 4 patients died after final operation in the staged surgery group. The Z value of tricuspid valve (P=0.013) and severe right ventricular dysplasia (P=0.025) were the risk factors of postoperative death in the patients with PA/IVS. Furthermore, 58 patients completed final operation, and the total number of the final operation (including one-stage radical surgery) accounted for 55.6% (84/151). Five patients accepted the re-operation intervention in the medium-term follow-up. The rest of the patients recovered well. Only 2 patients were classified as grade Ⅲ in cardiac function, and the rest patients were classified as gradeⅠ-Ⅱ.ConclusionAccording to the degree of right ventricular hypoplasia, the age at operation and the presence or absence of coronary artery malformation, the individualized surgical strategy could significantly improve the success rate of PA/IVS, and early completion of right ventricular decompression operation is conducive to improve the chance for biventricular repair.

    Release date:2020-05-28 10:21 Export PDF Favorites Scan
  • Review and Prospect of Total Cavopulmonary Connection

    Fontan operation is still a main procedure for treatment of complex congenital heart disease, such as univentricular heart. Fontan procedure has undergone many revisions since its introduction in 1968. The earlyapplied atriumpulmonary connection has been replaced by total cavopulmonary connection. The midterm and late results of both the intraatrial lateral tunnel and extracardiac total cavopulmonary connections were compared and analyzed in this article. Extracardiac conduit is better. The Fontan circulation failure would appear at last because of nopump function of the right ventricle. Once Fontan circulation failure occurred and could not recover by medicine, heart transplantation is mandatory, but the source of donor heart is lacking. The study of mechanical cavopulmonary assist device, to “biventricularize” the univentricular Fontan circulation, has been developed, which is quite promising. Following the development of diagnostic and treatment techniques for fetal heart disease, the treatment procedure of complex congenital heart disease has been broadened in recent years, such as to prevent the severe aortic stenosis from developing into hypoplastic left heart syndrome with fetal cardiac intervention so as to increase the chance of biventricular repair, and to terminate gestation to decrease its birth rate of complex heart abnormalities, which could not be completely repaired to date.

    Release date:2016-08-30 05:56 Export PDF Favorites Scan
  • Effects of fenestration on long-term results of extracardiac total cavopulmonary connection patients in different risk levels

    ObjectiveTo evaluate the long-term effects of fenestration on patients at different risk levels, who performed external conduit total cavo-pulmonary connection operation.MethodsThis was a retrospective analysis which enrolled 383 patients undergoing external conduit total cavo-pulmonary connection in Fuwai Hospital from 2008 to 2015. Based on the preoperative data and whether fenestration in the operation, the whole cohorts were divided into four subgroups: a high risk group with fenestration(mean age: 10.53±7.06 years, 55 males), a high risk group with non-fenestration(mean age: 9.30±7.83 years, 43 males), a low risk group with fenestration(mean age: 8.91±7.13 years, 65 males) and a low risk group with non-fenestration(mean age: 8.23±5.34 years, 67 males). Then we collected and analyzed the perioperative data and long-term prognosis of this cohorts in different risk levels.ResultIn the high-risk group, the duration of chest drainage in fenestration group was significantly shorter than that of the non-fenestration group (12.39±12.03 d vs. 23.30±15.36 d, P=0.001). The incidence of delayed chest drainage in the fenestration group was lower than that in the non-fenestration group (25.0% vs. 47.1%, P=0.002). In addition, the length of hospital stay was shorter than that of the non-fenestration group (18.91±12.79 d vs. 29.68±37.77 d, P=0.004), with significant statistical difference. In the low risk group, there were 3 (2.7%) and 2 (1.6%) deaths at the follow-up in the non-fenestration and fenestration groups respectively (P=0.761). And 1 patient (1.3%), 1 patient (1.4%) died in the fenestration and non-fenestration group (P=0.593) in high risk group. However, there was no statistically significant difference among the fenestration and non-fenestration groups in terms of long-term intestinal protein loss syndrome and arrhythmia in different risk level groups.ConclusionFenestration can reduce the incidence of early complications and hospital stay, effectively, especially for the high-risk patient. Fenestration is recommended for high-risk patients with external conduit total cavo-pulmonary connection operation.

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  • 单心室心脏分期术后机械循环支持的临床经验

    目的 探讨单心室心脏分期手术后循环衰竭行机械辅助的临床结果及治疗意义。 方法 2008 年 1 月至 2017 年 6 月上海儿童医学中心 89 例患者心脏术后行机械辅助,其中单心室心脏手术后行机械辅助 4 例(4.5%)。3 例为 Glenn 术后,1 例为 B-T 分流术后。辅助方式均为正中经胸的静脉-动脉体外膜肺氧合(V-A ECMO)技术。3 例 ECMO 插管方式为右心房单根静脉回流, 1 例 Glenn 术后加用上腔静脉插管增加静脉引流量。单心室转流期间 ECMO 按常规管理。分析单心室术后需要机械辅助支持的原因、辅助方式、插管特点及临床结果。 结果 4 例单心室机械辅助病例,3 例 ECMO 撤机成功,1 例因持续性肺动脉高压放弃治疗。辅助时间为 104(55~504)h。治疗中 1 例,1 例长期随访中,出院 2 例,其中 1 例出院后 2 周在当地死亡,死亡原因不明。 结论 单心室术后的辅助循环脱机成功率较低。应根据患儿临床情况尽早启用,以提高存活率。非搏动性血流与搏动性血流的机械辅助效果尚待临床验证。针对 Fontan 循环衰竭患儿的长期心室辅助装置辅助是机械辅助领域最具挑战性的热点。

    Release date:2017-12-29 02:05 Export PDF Favorites Scan
  • Surgical treatment strategy and outcome of functional univentricular heart with total anomalous pulmonary vein drainage

    Objective To explore the surgical management method and outcome of functional univentricular heart with total anomalous pulmonary vein drainage (UVH-TAPVD). Methods We reviewed the surgical procedures and results for 44 UVH-TAPVD patients in our hospital between the year 2010 and 2016. There were 34 males and 10 females. The age of the patients was 312 (77-4 220) d when they accepted the first surgical treatment. Results There were 8 deaths in stage Ⅰ palliation, 1 death in stage Ⅱ palliation and 5 deaths during the follow-up. The overall survival rate was 68.2% (30/44). Glenn operation was undertaken in 34 patients with 5 deaths. Fontan operation was undertaken in 9 patients with 2 deaths. Conclusion Surgical strategies for UVH-TAPVD should be planned according to different anatomical and pathophysiological conditions in different patients. Staged palliations can reduce mortality and morbidity. But pulmonary venous obstruction and heterotaxy syndrome are still risk factors for these patients.

    Release date:2018-01-31 02:46 Export PDF Favorites Scan
  • Connecting hepatic vein and azygos vein by an autologous pericardial conduit to complete a Fontan procedure through a unilateral thoracotomy: A case report

    We reported a case of a six-year-old boy diagnosed of single ventricle, pulmonary atresia and interrupted inferior vena cava. After modified Blalock-Taussig shunt and bidirectional Glenn procedure, he received the Fontan procedure. The Fontan procedure was done through a unilateral thoracotomy, using an autologous pericardial conduit to connect hepatic vein and azygos vein. The result of short-term follow-up was satisfactory.

    Release date:2021-09-18 02:21 Export PDF Favorites Scan
  • Chinese expert consensus on surgical treatment of congenital heart disease (8): Series of procedures for univentricular heart

    In patients with a functionally univentricular heart, the Fontan strategy achieves separation of the systemic and pulmonary circulation and reduction of ventricular volume overload. Contemporary modifications of surgical techniques have significantly improved survival rate. However, the resulting Fontan physiology is associated with high morbidity. Despite large improvements in outcomes of contemporary Fontan patients, a large burden of disease exists in this patient population. In face of the imbalance of medical resources in China and different understanding of Fontan treatment in various regions, there is no consensus on the current status of Fontan strategy, surgical technique and perioperative treatment. By reviewing large amounts of literature, assessing survival rate and risk factors for mortality and complications of the Fontan circulation, knowledge sharing from tens of experts, we achieved a consensus on many aspects of palliation of Fontan. We hope this consensus will help Chinese colleagues further continue their efforts to improve surgical outcomes of the univentricular heart patients.

    Release date:2020-09-22 02:51 Export PDF Favorites Scan
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