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find Keyword "复发性" 82 results
  • 复发难治性套细胞淋巴瘤的治疗进展

    套细胞淋巴瘤(MCL)是一组以t(11;14)和细胞周期蛋白D1阳性过度表达为特征的侵袭性非霍奇金淋巴瘤(NHL),约占NHL发病的3%~10%,预后较差,生存期仅为3~5年。复发难治性MCL预后极差,第1次复发后,中位生存期仅1~2年,现有治疗方法仍不能治愈MCL,许多新的作用于细胞周期和凋亡通路的药物,如蛋白酶体抑制剂、免疫调节剂、雷帕霉素靶蛋白抑制剂、组蛋白去乙酰化酶抑制剂取得了令人鼓舞的疗效,为复发难治性MCL患者带来新的希望。现就近年国际上复发难治性MCL的治疗进展作一综述。

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  • Clinical Analysis of Reoperation for Recurrent Gastric Cancer

    目的:探讨胃癌术后复发的临床特点及再手术适应症。方法:回顾性分析我院2000年1月至2009年1月收治的46例复发性胃癌再次手术病例的临床资料。结果:术中探查发现30例侵及毗邻器官,16例淋巴结转移,术后生存5年以上1例、3年以上18例、1年以上3例、1年以内死亡15例。结论:术后定期胃镜检查有助于复发性胃癌的早期诊断和提高手术率。选项择身体素质好、肿瘤复发局限者采取再次手术治疗,可延长生存时间,提高疗效。

    Release date:2016-09-08 10:01 Export PDF Favorites Scan
  • 32例复发性念珠菌性外阴阴道炎的临床分析

    摘要:目的:探讨导致复发性念珠菌性外阴阴道炎的致病因素。方法:回顾性分析我院3年来门诊复发性念珠菌性外阴阴道炎的的治疗情况。结果:糖尿病是导致复发性念珠菌性外阴阴道炎的重要因素之一。结论:糖尿病的诊治在降低念珠菌性外阴阴道炎反复发作中起重要作用。

    Release date:2016-09-08 10:12 Export PDF Favorites Scan
  • Status and progress of surgical treatment of postoperative recurrent hepatocellular carcinoma

    ObjectiveTo summarize the current status and progress of surgical treatment for postoperative recurrent hepatocellular carcinoma (HCC).MethodThe literatures about studies of surgical treatment of postoperative recurrent HCC were reviewed.ResultsThe surgical operation was an effective method for the treatment of recurrent HCC. The operation methods included re-hepatectomy and salvage liver transplantation. There was no uniform standard for the indication of re-hepatectomy, but the basic principles were the same. At present, the indication of salvage liver transplantation was mainly based on Milan criteria. For patients with recurrent HCC who met the operation indications, surgical operation could improve the long-term survival rate of patients and benefit the patients.ConclusionIt migh prolong the survival time and improve the long-term survival rate of patients with recurrent HCC when the appropriate patients and reasonable surgical methods are chosen according to the surgical indications, the tumor situation of initial hepatectomy, postoperative recurrence time, and other factors.

    Release date:2021-04-30 10:45 Export PDF Favorites Scan
  • HCG联合地屈孕酮治疗复发性早期流产

    目的 探讨HCG联合地屈孕酮治疗复发性早期流产的治疗效果。 方法 2007年6月-2009年6月将76例有复发性早期流产史并诊断为黄体功能不全的患者作为观察组,随机分为HCG+地屈孕酮组和单用黄体酮治疗两组。HCG+地屈孕酮组各治疗12周。另选正常早孕健康妇女38例为对照组,无任何处理。检测血清P、E2和HCG水平以评估治疗结果,记录妊娠结果及行统计学分析。 结果 8周之前,HCG+孕酮组与对照组相比,HCG、E2、P的水平明显低于正常对照组孕妇,有统计学意义(Plt;0.05)。HCG+孕酮组与黄体酮组相比无差;8~12 周, HCG、E2、P的水平接近于正常对照组孕妇,无统计学意义(P>0.05)。与黄体酮组比较P有统计学意义(Plt;0.05)。妊娠情况:HCG+孕酮组38例,足月妊娠分娩成功37例(97%),黄体酮组38例,足月妊娠分娩26例(68%),两组相比无有统计学意义(P>0.05)。 结论 HCG联合地屈孕酮治疗复发性早期流产疗效好,可明显提高妊娠成功率。

    Release date:2016-09-08 09:47 Export PDF Favorites Scan
  • Clinical application and effectiveness of patellar tunnel locator in medial patellofemoral ligament reconstruction surgery

    ObjectiveTo evaluate the operability and effectiveness of a self-developed patellar bone canal locator (hereinafter referred to as “locator”) in the reconstruction of the medial patellofemoral ligament (MPFL). Methods A total of 38 patients with recurrent patellar dislocation who met the selection criteria admitted between January 2022 and December 2022 were randomly divided into study group (the patellar canal was established with a locator during MPFL reconstruction) and control group (no locator was used in MPFL reconstruction), with 19 cases in each group. There was no significant difference in baseline data between the two groups (P>0.05), such as gender, age, body mass index, disease duration, patella Wiberg classification, constituent ratio of cartilage injury, Caton index, tibia tubercle-trochlear groove, and preoperative Lysholm score, Kujal score, Tegner score, visual analogue scale (VAS) score, and so on. The Lysholm score, Kujal score, Tegner score, and VAS score were used to evaluate knee joint function before operation and at 3 days,1 month, 3 months, and 6 months after operation. The ideal prepatellar cortical thickness and canal length were measured before operation, and the actual prepatellar cortical thickness and canal length after operation were also measured, and D1 (the distance between the ideal entrance and the actual entrance), D2 (the ideal canal length minus the actual canal length), D3 (the ideal prepatellar cortical thickness minus the actual prepatellar cortical thickness) were calculated.ResultsPatients in both groups were followed up 6-8 months (mean, 6.7 months). The incision length and intraoperative blood loss in the study group were smaller than those in the control group, but the operation time was longer than that in the control group, the differences were significant (P<0.05). There was no complication such as incision infection, effusion, and delayed healing in both groups, and no further dislocation occurred during follow-up. One patient in the study group had persistent pain in the anserine area after operation, and the symptoms were relieved after physiotherapy. The VAS score of the two groups increased significantly at 3 days after operation, and gradually decreased with the extension of time; the change trends of Lysholm score, Kujal score, and Tegner score were opposite to VAS score. Except that the Lysholm score and Kujal score of the study group were higher than those of the control group at 3 days after operation, and the VAS score of the study group was lower than that of the control group at 3 days and 1 month after operation, the differences were significant (P<0.05), there was no significant difference in the scores between the two groups at other time points (P>0.05). Patellar bone canal evaluation showed that there was no significant difference in preoperative simulated ideal canal length, prepatellar cortical thickness, and postoperative actual canal length between the two groups (P>0.05). The postoperative actual prepatellar cortical thickness of the study group was significantly smaller than that of the control group (P<0.05). D1 and D3 in the study group were significantly higher than those in control group (P<0.05), but there was no significant difference in D2 between the two groups (P>0.05). ConclusionThe locator can improve the accuracy of MPFL reconstruction surgery, reduce the possibility of intraoperative damage to the articular surface of patella and postoperative patellar fractures.

    Release date:2023-10-11 10:17 Export PDF Favorites Scan
  • 18 例以下呼吸道受累为首发表现的复发性多软骨炎临床分析

    目的分析以下呼吸道受累为首发表现的复发性多软骨炎的临床特征,以提高诊断和治疗水平。方法收集四川大学华西医院 2015 年 1 月至 2018 年 12 月收治的以下呼吸道受累为首发表现的复发性多软骨炎住院患者 18 例临床资料,进行回顾性分析,并进行相关文献复习。结果18 例患者中,男 13 例,女 5 例,年龄 26~71 岁。症状:咳嗽 17 例(94%),咳痰 16 例(89%),气紧 15 例(83%),发热 7 例(39%),声嘶 6 例(33%),胸痛 4 例(22%)。计算机体层成像(CT)及支气管镜发现狭窄或黏膜肿胀增厚 17 例(94%)。1 例行气管切开,安置气管套管。11 例单用糖皮质激素治疗,6 例使用糖皮质激素联合免疫抑制剂治疗,1 例放弃治疗。结论复发性多软骨炎患者在疾病早期临床症状无特异性,易造成不重视,同时易出现误诊漏诊。CT、气管镜检查及正电子发射计算机体层成像对确诊有较大临床意义。糖皮质激素和免疫抑制剂治疗有效。

    Release date:2021-04-25 10:17 Export PDF Favorites Scan
  • Clinical Features and Common Etiologies of Recurrent Acute Pancreatitis

    Objective To analyze the clinical features, common etiologies, prevention measurements of recurrent acute pancreatitis (AP). Methods The clinical characteristics and imaging examination data of 43 patients with recurrent AP were analyzed retrospectively, which was compared with the results of 258 patients with primary AP. The recurrence etiologies were analyzed. Results There were no significant differences on the fever, jaundice, abdominal pain relief time, pancreatic local complications, and ratio of severe AP between two groups (P>0.05). Comparion of etiologies between recurrent AP and primary AP, cholecystitis and diet factor (alcoholic) had priority in patients with primary AP (P=0.038, P=0.006, respectively), but the hyperlipidemic, duodenal nipple disease, and small stone in the common bile duct were the major etiologies in patients with recurrent AP (P=0.007, P=0.008, respectively). No relapse was found within the follow up for 3 months to 2 years (the average time was 14.2 months). Conclusion Find out the exact etiology and performe correct therapy are the key to the treatment and prevention of recurrent AP.

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
  • Early-term effectiveness of Latarjet procedure by coracoid osteotomy with preserving coracoacromial ligament for recurrent anterior shoulder dislocation

    Objective To evaluate the early-term effectiveness of Latarjet procedure with double EndoButtons fixation for recurrent anterior shoulder dislocation by coracoid osteotomy with preserving coracoacromial ligament. Methods Between January 2021 and June 2023, 19 patients with recurrent anterior shoulder dislocations were treated by arthroscopic Latarjet procedure with double EndoButtons fixation, all of which underwent coracoid osteotomy with preserving the coracoacromial ligament. There were 11 males and 8 females, with an average age of 23.3 years (range, 17-32 years). Shoulder dislocations ranged from 3 to 11 times, with an average of 6.4 times. The disease duration ranged from 3 to 35 months, with an average of 12.9 months. All apprehension tests were positive. Imaging examination showed that the defect width of the ipsilateral glenoid bone was 13%-26%, with an average of 19.8%. After operation, the shoulder range of motion was examined, including flexion lift, lateral external rotation, extension 90° external rotation, and internal rotation. Shoulder joint function was evaluated by Walch-Duplay score, American Association for Shoulder and Elbow Surgery (ASES) score, and Rowe score. Imaging examinations were taken to observe the position and shaping of coracoid. Results All incisions healed by first intention and no nerve or vessel injury occurred. All patients were followed up 9-24 months (mean, 14.5 months). There was no recurrence of shoulder dislocation and the apprehension tests were negative during follow-up. There was no significant difference in the shoulder range of motion (flexion lift, lateral external rotation, extension 90° external rotation, and internal rotation) between preoperation and at last follow-up (P>0.05). The Walch-Duplay score, ASES score, and Rowe score significantly improved when compared with those before operation (P<0.05). Postoperative imaging showed that coracoid graft was at the same level with the glenoid in all cases; the center of coracoid graft was located between 3 to 5 o’clock. During follow-up, there was no glenohumeral joint degeneration, the acromiaohumeral distance was not reduced when compared with preoperation, and the coracoid bone gradually formed concentric circles with the humeral head. Conclusion The Latarjet procedure with double EndoButtons fixation can effectively treat recurrent anterior shoulder dislocation by coracoid osteotomy with preserving coracoacromial ligament, and the early-term effectiveness is satisfactory.

    Release date:2024-06-14 09:52 Export PDF Favorites Scan
  • Clinical characteristics of dynamic benign tracheobtonchial stenosis: two cases report

    Objective To improve the knowledge on dynamic benign central airway stenosis through two typical cases. Methods The clinical features, imaging findings, and bronchial morphologic changes of two cases characterized by dynamic benign central airway stenosis were retrospectively analyzed. The etiologies for the two cases were tracheobronchomalacia (TBM) and excessive dynamic airway collapse (EDAC), respectively. Results Central airway stenosis and reversible airway obstruction were common clinical characteristics for the two cases. However, there were identifiable differences on imaging findings and bronchial morphologic changes between the two cases. Multidetector computed tomography showed sabre-sheath trachea and narrowed trachea in coronal position for TBM, while small sized trachea in exhalation phase and narrowed trachea in sagittal position for EDAC. Bronchoscopy displayed narrowed airway, swelling mucosa, and the absence of annular cartilage for TBM, while crescent airway with membranacea part protruding to lumen in inspiration phase, and the integrity of annular cartilage for EDAC. Conclusion Multidetector computed tomography and bronchoscopy examinations are valid methods to distinguish TBM and EDAC, which are both characterized by dynamic benign central airway stenosis.

    Release date:2018-05-28 09:22 Export PDF Favorites Scan
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