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find Keyword "干扰素" 60 results
  • Clinical Characteristics of Dynamic in the Treatment of HBeAg Postive Chronic Hepatitis B with IFN-α

    目的:观察α干扰素治疗HBeAg(+)慢性乙型肝炎患者过程中病毒学及血清学动态变化情况,通过早期疗效预测终末疗效。方法:观察144例HBeAg(+)慢性乙型肝炎患者经α干扰素治疗24WK及随访24WK 过程中HBV-DNA以及HBeAg变化情况.结果:经α干扰素治疗12、24、48WK时,HBV-DNA下降到可检测值以下病例数分别为32、32、31例;同期HBeAg发生血清转换病例数分别为16、17、21例。结论:干扰素治疗12WK时患者病毒学及血清学结果可早期预测终末疗效。

    Release date:2016-09-08 10:04 Export PDF Favorites Scan
  • Antivirus Therapy of Lamivudine Resistant Chronic Hepatitis B Patients

    目的 采用干扰素和阿德福韦酯治疗慢性乙型肝炎患者经拉米夫定治疗后出现YMDD变异,比较两种治疗策略的临床疗效。 方法 选择2002年2月-年12月经100 mg拉米夫定治疗后出现YMDD变异的慢性乙型肝炎患者76例。其中,男52例,女24例;年龄18~55岁,平均年龄33岁。服用100 mg拉米夫定52~156周发生YMDD变异,HBV DNA低于治疗前水平,丙氨酸转移酶(alanine aminotransferase,ALT)lt;2×ULN/L患者分为A组(26例),继续用100 mg拉米夫定治疗48周;服用100 mg拉米夫定52~156周发生YMDD变异,HBV DNA定量检测高于或等于治疗前水平,ALTgt;2×ULN/L,根据患者自愿分为B组(27例)和C组(23例)。B组用100 mg拉米夫定联合10 mg阿德福韦酯治疗48周;C组用干扰素治疗48周。分别观察3组ALT复常率及HBV DNA转阴率、HBeAg阳性患者血清学转换率。 结果 治疗48周时,B、C组患者ALT复常率分别是74.1%和78.3%,明显高于A组的34.6%,差异有统计学意义(Plt;0.05);B、C组患者HBV DNA转阴率分别是77.7%和73.9%,明显高于A组的11.5%,差异有统计学意义(Plt;0.05);3组HBeAg阳性患者血清学转换率比较,差异均无统计学意义(Pgt;0.05)。 结论 慢性乙型肝炎患者经拉米夫定治疗后出现YMDD变异,继续用拉米夫定治疗疗效不理想,改用干扰素或联合阿德福韦酯治疗更安全有效。

    Release date:2016-09-08 09:47 Export PDF Favorites Scan
  • Clinical Study on Varicella Treated with IFN-α

    目的:探讨干扰素治疗水痘的效果。方法:将151例水痘患者随机分为3组, 治疗组Ⅰ给予干扰素100 万U/ 次,im,隔日1 次,连用3 次,治疗组Ⅱ同时予以干扰素局部外涂于水痘处, 2 次/ d;对照组病毒唑10 mg/ (kg·d),im, 一日2 次,连用5 天。除以上治疗外,3组均同时根据病情给予退热、止痒、抗炎等对症治疗。观察3组患者症状、体征变化。结果:治疗组患者症状、体征恢复所用时间明显优于对照组,同时还发现局部外涂干扰素于水痘处,其皮疹瘙痒、结痂恢复天数明显缩短。结论:干扰素治疗水痘可减轻症状,缩短病程,配合局部外用效果更佳。

    Release date:2016-09-08 09:56 Export PDF Favorites Scan
  • 难治性哮喘中Th1/Th2失衡机制

    【摘要】 支气管哮喘是一种由多种细胞包括气道的炎性细胞、结构细胞和细胞组分参与的气道慢性炎症性疾病。临床上少数患者通过充分的哮喘治疗包括使用全身性激素治疗后仍不能有效控制, 通常称为“难治性哮喘”。免疫反应在难治性哮喘发病机制中起重要作用,而Th1/Th2失衡贯穿于难治性哮喘发病的整个过程。现就难治性哮喘中Th1/Th2失衡机制,以及影响因子(干扰素-γ、白介素-12、白介素-4、白介素-17,白介素-33和转化生长因子-β等)的研究作一综述,以深入探讨难治性哮喘的发病机制。

    Release date:2016-09-08 09:26 Export PDF Favorites Scan
  • 慢性丙型肝炎抗病毒治疗个体化疗程选择

    丙型肝炎病毒感染后大多数患者转为慢性感染,若不及时正确地进行治疗,相当比例患者会产生严重临床后果,丙型肝炎患者一旦确诊应积极行抗病毒治疗。根据病毒基因型及患者治疗过程中病毒学应答情况来预测疗效并相应调整治疗方案,成为目前抗病毒治疗的研究热点。

    Release date:2016-09-08 09:18 Export PDF Favorites Scan
  • Diagnostic Value of Interferon-γ Release Assay (TB-IGRA) for Tuberculosis in the Tibetan

    ObjectiveTo evaluate the diagnostic value of interferon-gamma release assay (TB-IGRA) for tuberculosis in the Tibetan. MethodsFrom January 2014 to December 2014, suspected Tibetan tuberculosis patients were enrolled from AVIC 363 Hospital and underwent TB-IGRA test. All patients were also underwent smear test for Mycobacteria. The diagnostic value of TB-IGRA test for Tibetan TB patients was analyzed. ResultsA total of 77 suspected Tibetan tuberculosis patients were included. According to the diagnostic criteria, of the 77 suspected patients, 50 were diagnosed as TB patients, and 27 were diagnosed as not-TB patients. The sensitivity and specificity of TB-IGRA test was 86% and 81.5%. While the sensitivity and specificity of smear test were 22% and 100%, respectively. ConclusionThe TB-IGRA test is superior to smear test, and is the fast and sensitivity test for diagnosing Tibetan TB patients.

    Release date:2016-10-02 04:54 Export PDF Favorites Scan
  • Efficacy and safety of pegylated interferon α-2a initially combined with entecavir in treatment of HBeAg-positive chronic hepatitis B: a meta-analysis

    ObjectivesTo systematically review the efficacy and safety of pegylated interferon α-2a (Peg-IFNα-2a) combined with entecavir (ETV) versus Peg-IFNα-2a alone in treatment of HBeAg-positive chronic hepatitis B (CHB) patients.MethodsThe Cochrane Library, PubMed, Web of Science, EMbase, CNKI, VIP and WanFang Data databases were electronically searched to collect randomized controlled trials (RCTs) on Peg-IFNα-2a combined with ETV for HBeAg-positive CHB from inception to March, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 12 RCTs involving 1 130 patients were included. The results of meta-analysis showed that: compared with Peg-IFNα-2a monotherapy, Peg-IFNα-2a combined with ETV could improve the rate of serum HBV-DNA clearance (RR=2.55, 95%CI 1.83 to 3.55, P<0.000 01), ALT normalization (RR=2.37, 95%CI 1.76 to 3.20, P<0.000 01) and HBeAg seroconversion (RR=2.88, 95%CI 1.18 to 7.03, P=0.02) after 12 weeks of treatment. Additionally, it could improve the rate of serum HBV-DNA clearance (RR=2.10, 95%CI 1.74 to 2.53, P<0.000 01), AST normalization (RR=1.87, 95%CI 1.15 to 3.04, P=0.01), ALT normalization (RR=1.70, 95%CI 1.46 to 1.99, P<0.000 01), serum HBeAg clearance (RR=2.14, 95%CI 1.62 to 2.83, P<0.000 01), HBeAg seroconversion (RR=2.51, 95%CI 1.65 to 3.82, P<0.000 01) and serum HBsAg clearance (RR=2.78, 95%CI 1.06 to 7.31, P=0.04) after 24 weeks of treatment. It could also improve the rate of serum HBV-DNA clearance (RR=1.63, 95%CI 1.32 to 2.02, P<0.000 01), AST normalization (RR=2.75, 95%CI 1.82 to 4.16, P<0.000 01), ALT normalization (RR=1.47, 95%CI 1.33 to 1.63, P<0.000 01), serum HBeAg clearance (RR=1.65, 95%CI 1.42 to 1.91, P<0.000 01), HBeAg seroconversion (RR=1.91, 95%CI 1.51 to 2.41, P<0.000 01) and serum HBsAg clearance (RR=1.57, 95%CI 1.07 to 2.31, P=0.02) after 48 weeks of treatment. There was no statistically significance of adverse reactions in groups.ConclusionsCurrent evidence shows that Peg-IFNα-2a combined with ETV is superior to Peg-IFNα-2a monotherapy in the treatment of HBeAg-positive CHB, and does not increase the incidence of adverse reactions. Due to the limited quality and quantity of the included studies, more high quality studies are required to verify the above conclusion.

    Release date:2019-11-19 10:03 Export PDF Favorites Scan
  • Meta-analysis of Maintenance Therapy With Interferon for Small Cell Lung Cancer

    Objectives To evaluate the efficacy of interferon (IFN) maintenance therapy in patients with small cell lung cancer (SCLC). Methods We searched MEDLINE (1966-Jan.2006), EMbase (1984-Jan.2006), The Cochrane Library(Issue 1, 2006)and the Chinese Biomedical Database (1980-Jan.2006). We checked the references in the reports of related studies and handsearched the education books of ASCO and ESMO meetings. The quality of the included trials was evaluated. Data were extracted by two reviewers independently into a specially designed extraction form. The Cochrane Collaboration’s RevMan 4.2.7 software was used for data analysis. Results Five randomized controlled trials involving 587 patients were included. The pooled result of the 5 studies showed that IFN plus chemotherapy induction treatment did not have a significant effect on 1-year (RR 1.19, 95%CI 0.88-1.6) or 2-year survival rate (RR 1.44, 95% CI 0.99-2.10). However, IFN maintenance therapy significantly increased 2-year (RR 2.08, 95%CI 1.16-3.72) and 1-year survival (RR 2.99, 95%CI 1.13-7.93). Conclusion IFN maintenance therapy may increase 2-year and 1-year survival rates after patients have achieved complete or partial response to chemotherapy. Further randomized, double-blind multi-center trials are needed to investigate this further.

    Release date:2016-09-07 02:17 Export PDF Favorites Scan
  • 恶性黑色素瘤综合治疗的护理体会

    目的 探讨恶性黑色素瘤手术结合大剂量重组干扰素α-2a治疗的护理措施,总结最佳护理方法。 方法 回顾性总结2001年1月-2011年12月138例恶性黑色素瘤手术结合大剂量重组干扰素α-2a治疗的护理措施,包括心理护理以及营养支持,伤口的观察、疼痛护理、并发症的观察与处理方法。 结果 经过密切观察及精心护理,136例患者伤口顺利愈合。 结论 术前进行心理疏导,术后密切的伤口观察,对重组干扰素α-2a使用不良反应的观察和护理等能加快患者的康复。

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  • Evidence-Based Treatment of Hepatitis C after Kidney Transplantation with Combined Interferon-α and Ribavirin

    Objective To formulate an evidence-based treatment plan for a patient with hepatitis C after kidney transplantation with combination of interferon-α and ribavirin. Methods Based on an adequate assessment of the patient’ s condition and using the principle of PICO, we searched The Cochrane Library (Issue 1, 2009), PubMed (1995 to March 2009), and CHKD (1995 to 2008.12). Results Eighteen studies were identified including 17 in English (5 case reports, 11 cohort studies, and 1 meta–analysis) and 1 in Chinese. According to the current evidence as well as the patient’ s clinical condition and preference, PEG-IFNα-2b 50 µg /week plus ribavirin 600 mg/day was given to the patient for 6 months. Conclusion Evidence-based approaches help us to prepare the anti-viral therapy plan and will improve the assessment of the efficacy and safety in kidney transplantation.

    Release date:2016-09-07 02:08 Export PDF Favorites Scan
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