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find Author "张海波" 44 results
  • 低温保护时心肌快速冷挛缩的研究进展

    心肌低温保护时快速冷挛缩(rapid cooling contracture,RCC)现象近来日益受到人们重视。快速冷挛缩现象是指快速制冷诱发的非去极化的心肌挛缩。其机制可能与心肌细胞内温度依赖性Ca2+快速升高有关。降温过程中,肌浆网内存Ca2+迅速释放,并与肌钙蛋白相结合,引起蛋白构象发生变化,通过粗、细肌丝相对滑行而产生心肌收缩。快速冷挛缩的危害为能量的消耗、冠状血管阻抗增大、心脏功能降低、Ca2+超负荷等方面,尤其对于未成熟心肌危害更大。目前有些学者提出用心肌温保护和预防Ca2+超负荷等方法来避免其危害的发生。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • 第四届安贞心脏瓣膜介入治疗新技术高峰论坛暨心脏全瓣膜介入技术Workshop培训工坊会议纪要

    Release date:2023-08-31 05:57 Export PDF Favorites Scan
  • Chinese expert consensus on surgical treatment of congenital heart disease (11): Coarctation of the aorta and interrupted aortic arch

    Coarctation of the aorta and interrupted aortic arch are congenital anomalies affecting the aortic arch. Because of the poor natural prognosis, many patients will need early surgical repair or even emergency surgery. With the improvement of the surgical techniques, cardiopulmonary bypass techniques and perioperative intensive care, surgical mortality has now dramatically decreased. However, aortic arch restenosis, left ventricular outflow tract obstruction and long-term hypertension are problems that may be still encountered during the follow-up period. By reviewing large amounts of literature and discussing among experts, we achieved a consensus on many aspects of the management strategy. We hope this consensus will help Chinese colleagues further improve the overall surgical outcomes of coarctation of aorta and interrupted aortic arch.

    Release date:2020-12-07 01:26 Export PDF Favorites Scan
  • Surgical Treatment of Sinus Venosus Atrial Septai Defect

    Objective To summarize the experiences of surgical treatment of sinus venosus atrial septal defect (SVASD). Methods There were 32 patients of SVASD, all of them were associated with totally or partially right anomalous pulmonary venous connection. There were 25 cases of superior SVASD, 22 cases underwent double-patch procedure, 3 cases underwent Warden procedure. In 7 cases of inferier SVASD, 3 cases of Scimitar syndrome underwent ASD repair by pericardial patch and at the same time the anomalous pulmonary vein was divided and reimplanted to the posterior wall of left atrium, 4 cases of them underwent single-patch ASD repair. Results The surgical results were satisfying and no patient died, 28 patients were in sinus rhythm and echocardiography showed neither obstruction of caval vein and right pulmonary vein nor residual interatrial shunt. Conclusion SVASD mostly associated with right anomalous pulmonary venous connection according to its special anatomic structure. Preserving the function of sinus node and avoiding of obstruction of caval vein should be routinely considered when superior SVASD was repaired. The heart function of Scimitar syndrome should be followed-up for a long time for it usually associated with right lung hypoplasia.

    Release date:2016-08-30 06:18 Export PDF Favorites Scan
  • 一期手术纠治主肺动脉窗及伴发畸形

    目的 总结一期手术纠治主-肺动脉窗及伴发畸形的临床经验,以提高手术疗效。 方法 我科共收治26例主-肺动脉窗患者,男14例,女12例;年龄1.4±1.6岁;体重7.8±3.8kg。其中单纯主-肺动脉窗8例,合并主动脉弓中断、右肺动脉异常起源于主动脉、法洛四联症、房间隔缺损、室间隔缺损、二尖瓣反流和气管狭窄等18例。25例患者一期手术经主动脉切口补片关闭瘘口纠治主-肺动脉窗,同时纠治伴发的畸形;1例放弃治疗。 结果 全组无手术死亡。2例伴主动脉弓中断、动脉导管未闭和右肺动脉起源于升主动脉的新生儿术后3d延迟关胸;1例术后出血,3h后再次开胸止血。术后随访22例,随访时间1个月~4年。所有患者无明显的主动脉瓣上狭窄和肺动脉分支狭窄,2例残留轻度二尖瓣反流,1例残留轻至中度二尖瓣反流。 结论 主-肺动脉窗患者早期易发生肺动脉高压,一经诊断应立即手术。手术方式首选修补主肺动脉窗及一期纠治伴发畸形。尽管主-肺动脉窗可合并各种心内外畸形,但早期手术纠治可获得较好的中长期疗效。

    Release date:2016-08-30 06:09 Export PDF Favorites Scan
  • Investigation on the Examinees' Cognitive Level of X-ray Radiation

    ObjectiveTo study the examinees' cognitive level of the X-ray radiation, and to provide references for popularizing radiation protection knowledge. MethodWe chose patients who were checked in the Department of Radiology in our hospital between August 30 and October 29, 2013 as our study subjects, and carried out investigation by anonymous questionnaires. The investigation content included the respondents' basic information, ways to obtain the radiation knowledge, how well the patients knew about the fundamental radiation knowledge and their attitudes towards radiological examination and so on. A total of 2 315 patients were investigated, and 2 315 questionnaires were issued. Finally all questionnaires were retreated. ResultsAmong the 2 315 patients, 2026 (87.52%) knew the radiation symbol and 1 821 (78.66%) knew that X-ray radiation was harmful to the human body. Different age, gender, occupation, educational level and previous X-ray examination made significant differences in the fundamental knowledge on X-ray (P<0.05) . Attitudes towards X-ray examination was significantly different due to different age, occupation, and educational level (P<0.05) . Most examinees got the X-ray fundamental radiation knowledge from the publicity and medical staff in hospitals. ConclusionsTo make the examinees keep right attitudes and behaviors in radiographic examination, further effective methods of popularizing the basic knowledge of radiation should be carried out. Those publicity and medical staff in hospitals are the main force in the popularization of radiation knowledge.

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  • 膜式氧合器在胎羊体外循环中的运用

    目的 为了改进胎羊体外循环技术,探讨膜式氧合器在胎羊体外循环中的应用. 方法 将健康怀孕山羊8只,采用Dideco 901膜式氧合器和滚轴泵建立胎羊体外循环,常温(37℃)转流60分钟,氧合器内充低氧混合气体(8% O2和92% N2),监测胎羊的血压、心率、血气、血清乳酸和胎盘血管阻力. 结果 胎羊体外循环中动脉氧分压(PO2)和二氧化碳分压(PCO2)维持在宫内生理水平,胎羊心搏有力,血压正常.但胎羊pH值缓慢下降(P<0.05),血清乳酸值明显增高(P<0.01),胎盘血管阻力显著上升(P<0.01).停体外循环后胎羊出现低氧、高碳酸血症和酸中毒. 结论 胎羊体外循环影响胎盘功能,膜式氧合器可以代替胎盘气体交换功能,体外循环中胎羊生理低水平PO2是否适合其需要值得探讨.

    Release date:2016-08-30 06:32 Export PDF Favorites Scan
  • Indications for transcatheter interventions in tricuspid regurgitation

    Tricuspid regurgitation (TR) is a common but often neglected valvular heart disease. Growing evidence has highlighted its association with poor prognosis and the complexity of its management. In recent years, transcatheter tricuspid valve intervention (TTVI) has emerged as a promising minimally invasive approach, with accumulating evidence supporting its safety and short-term efficacy. Transcatheter approaches offer a new therapeutic alternative for high-risk TR patients, but the clinical indications for TTVI are still being refined. This review summarizes recent advancements in TTVI technology, compares the indications for surgical and transcatheter therapies, and discusses the critical role of right heart function and pulmonary circulation in therapeutic decision-making.

    Release date:2025-10-27 04:22 Export PDF Favorites Scan
  • Expert recommendations for standardized perioperative management after transapical transcatheter aortic valve implantation

    The technique of transcatheter aortic valve implantation has become increasingly mature. Although the transapical approach has a certain degree of minimally invasive trauma, it still has the characteristics such as heart beating without cardiopulmonary bypass, and the low technical requirements of catheter guide wire. In particular, the valve path is short and coaxial, which is easy to manipulate, and pure regurgitation and stenosis can be easily operated and are not subject to the limit of peripheral artery stenosis. It is still one of China's main approaches for transcatheter aortic valve replacement. Its perioperative management still has specific features and differs from the femoral artery approach. In addition, there is little relevant literature abroad. Therefore, domestic experts in this field were organized to discuss the development of perioperative management specifications to provide reference and techniques support for developing this field in China and further improve the quality of clinical operation and perioperative management. It will provide more safe and more effective medical services to these patients.

    Release date:2023-07-10 04:06 Export PDF Favorites Scan
  • Single Stage Repair of Interrupted Aortic Arch with Associated Cardiac Anomalies

    Abstract:Objective To summarize the experiences of single stage repair of interrupted aortic arch (IAA) associated with cardiac anomalies. Methods From Jan. 2000 to Dec. 2005, 48 patients admited in hospital and 35 patients were operated, the mean age at operation was 1.1 years. The associated anomalies included 23 cases of ventricular septal defect, 2 cases of transposition of great arteries, 3 cases of aortopulmonary window with aortic origin of right pulmonary artery, 2 cases of truncus arteriosus, 2 cases of double outlet right ventricle, 2 cases of stenotic fifth arch and 1 case of aberrant origin of right subclavian artery with mild hypoplastic decending aorta. Among them, 34 patients underwent single stage repair and 1 kid underwent palliative correction. Results There were 4 surgical deaths. The sequelae included one diaphragm paralysis and one 3rd degree of atrioventricular block. Only 5 kids recurred mild stenosis of aortic arch anastomosis and 2 death occurred during 3 months to 4 years of follow-up. Conclusion Though early surgical mortality for primary single stage repair is now relatively low, if appropriate interventions has been accomplished during perioperative period, but outcomes of IAA remain of concern, especially in patients with associated lesions.

    Release date:2016-08-30 06:23 Export PDF Favorites Scan
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