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波前像差技术在弱视中的应用

摘要:近年来，波前像差技术在眼科学中的研究和应用发展迅速，已成为目前眼科学的研究热点之一。其在儿童弱视中的应用也在不断发展，本文就波前像差与弱视的关系及其在弱视诊断、治疗中的应用做一综述。

弱视儿童不同遮盖方式生活质量评定分析

目的 比较弱视儿童行眼罩遮盖和 Bangeter 压抑膜遮盖的生活质量评分。 方法 选择 2014 年 11 月—2015 年 9 月视光门诊 7～12 岁弱视儿童 98 例，自愿选用眼罩或 Bangeter 压抑膜遵医嘱进行遮盖，6 个月后复诊时采用弱视儿童生活质量评估量表进行评分对比。 结果 眼罩遮盖组和Bangeter 压抑膜组男童的生活质量评分的平均得分[（6.00±3.34）、（8.79±4.48）分]均低于女童[（7.30±3.46）、（10.11±4.46）分]，差异均有统计学意义（t=2.032、2.654；P<0.05）。Bangeter 压抑膜组男、女童的视力状况、心理状况、社会交往、疾病担心得分亦明显高于眼罩遮盖组，差异均有统计学意义（P<0.05）。 结论 运用 Bangeter 压抑膜遮盖可提高弱视儿童的生活质量。

先天性玻璃体囊肿合并弱视1例

The pathogenetic mechanism of cortical deficit in people with strabismic amblyopia detected by functional MRI

Objective To detecte the pathogenetic mechanism of cortical deficit in persons with strabismic amblyopia by blood oxygenation level dependent-functional magnetic resonance imaging(BOLD-fMRI)． Methods The data of BOLD-fMRI of occipital visual cortex in 11 persons with strabismic amblyopia and 8 healthy ones were collected by 1．5T MRI system．The results of binocular pixel exponent in strabismic amblyopia group was compared with that in the normal group and the result of and average activation of cortical neuron in strabismic amblyopia group was analyzed.Results The binocular pixel exponent was lower in the strabismic amblyopia group(14．13％±4．55％)than that in the normal group(47．82％±5．34％)(PConclusions The reduction of cortical binocular cells and the undersampling and coding of higher-spatial-frequency components of visual stimuli may be related to the strabismic amblyopia．BOLD-fMRI may provide a new path to detecte the pathoffenetic mechanism of cortical deficit in people with strabismic amblyopia. (Chin J Ocul Fundus Dis，2004，20：19-22)

Characteristics of the multifocal visual evoked potentials in anisometropic amblyopes

Objective To investigate the characteristic of the multifocal visual evoked potentials(MVEP)and the visual function across the visual field in anisometropic amblyopes and isometropic amblyopes. Methods MVEP from 32 anisometropic amblyopic eyes and 31 control eyes were tested. Results In anisometropic amblyopic eyes,the latencies of MVEP were significantly prolonged．The amplitudes of MVEP were significantly attenuated in the central region of the visual field,and these phenomena gradually reduced with the increase of the eccentricity． Conclusion The visual function of anisometropic amblyopic eyes is reduced more significantly in the central region than in the peripheral region of the visual field. (Chin J Ocul Fundus Dis,20000,16:27-29)

Clinical Observation of Children Amblyopia

【摘要】 目的 探讨儿童弱视治疗效果与疗程的关系。 方法 对2002年5月-2007年5月收治的25例弱视患儿进行戴镜、遮盖、红光闪烁及精细作业训练。3个月复查一次，12个月重新验光，随访12~60个月。 结果 25例弱视患儿经12~60个月随访，25例患儿均治愈，治愈疗程最少3个月，最长达60个月，平均24个月。 结论 儿童弱视只要早期发现，在12岁之前进行干预，早期治疗均可获得治愈。【Abstract】 Objective To discuss the relationship between the effect and duration of the treatment for children amblyopia. Methods Patients diagnosed as amblyopia were administered wearing glasses, occlusion, flashing red, and fine training from May 2002 to May 2007. Reexamination was done 3 months later after the treatment, and the refraction examination was done after 12 months. The follow-up time was from 12 to 60 months. Results The results showed that all of the 25 amblyopic children were cured. The treatment duration was from three months to 50 months with an average of 24 months. Conclusion As long as the amblyopia is detected at the early stage and treated before age 12, all the children can be cured.

The interpretation of recommendation statement of US Preventive Services Task Force for vision screening in children aged 6 months to 5 years old

单侧原发性视网膜色素变性伴对侧弱视眼一例

Meta-analysis of subfoveal choroidal thickness changes in amblyopia based on spectral-domain optical coherence tomography

ObjectiveTo evaluate the changes in subfoveal choroidal thickness (SFCT) in amblyopic eyes.MethodsA evidence-based medicine study. Chinese and English as search terms for amblyopia and choroid was used to search literature in Wanfang, CNKI, and PubMed of National Library of Medicine. Incomplete or irrelevant literature and review literature were excluded. The literature was meta-analyzed using STATA 15.0. The weighted mean difference (WMD) and 95% confidence interval (CI) were selected as the estimated value of effect size, and subgroup analysis and sensitivity analysis were used to detect the source of heterogeneity.ResultsAccording to the search strategy, 75 articles were initially retrieved, and 15 articles were finally included for meta-analysis. A total of 650 patients with amblyopia, aged 3 to 65 years old, were included. The enhanced depth imaging technology of spectral domain optical coherence tomography was used to measure SFCT. The results of meta analysis showed that SFCT of amblyopic eyes was more effective than the contralateral eye (WMD=18.89 μm, 95% CI 14.81-22.98 μm, P＜0.001) and normal eyes were thicken (WMD=39.49 μm, 95% CI 33.88-45.09 μm, P＜0.001). There was no statistically significant difference in SFCT between anisometropic and strabismic amblyopia eyes (WMD=－5.03 μm, 95% CI －19.50-9.44 μm, P=0.495).ConclusionsThe SFCT of amblyopic eyes in amblyopic patients is thicker than that of the contralateral eye and normal eyes. There is no difference in SFCT between anisometropia and strabismus amblyopia.

烟毒性弱视一例