west china medical publishers
Keyword
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Keyword "心脏" 1107 results
  • In vitro experience with tissue engineered heart valve leaflets

    Objective To investigate the possibility of creation of tissue engineered heart valve leaflets in vitro . Methods Aorta were obtained from 9 hybrid young pigs. The endothelial cell, fibroblast and smooth muscle cells were isolated and cultured to get enough cell. The expanded fibroblast, smooth muscle cell,and endothelial cells were seeded on the polymers sequentially. The cell polymer constructs were sent for scanning electron microscopy(SEM) examination after cultured for 7, 14, and 28 days. Histological examination were performed after the cell polymer constructs cultured for 28 days. Results SEM showed that the number of cells on the polymers increased as the culture time prolonged, with the formation of matrix. After 28 days, there were a great number of cells and large amount of matrix on the scaffolds. The confluent cell had covered a large area of the polymers. Hematoxylin and eosin(HE) stain showed large amount of cells attached to the polymers. Conclusion With the viability of the cultured cellular scaffolds,it is possible to create tissue engineered heart valve leaflets in vitro.

    Release date:2016-08-30 06:27 Export PDF Favorites Scan
  • Changes of the Level of G Protein in Newborn Guinea-pig Myocardium Undergoing Global Ischemic Reperfusion

    ObjectiveTo study the changes of levels of α subunits of stimulatory (Gsα) and inhibitory guanine nucleotide binding protein (Giα) in newborn guinea pig (0 2 days old) myocardium undergoing global ischemic reperfusion, and influences on the changes by St.Thomas Ⅱ and cold blood cardioplegic solution.MethodsThirty newborn guinea pigs were randomly assigned to three groups. GroupⅠ ( n = 10): the newborn hearts suffered by hypothermic global ischemia; group Ⅱ( n =10): the newborn hearts arrested by St. Thomas Ⅱ , and group Ⅲ ( n = 10): the newborn hearts arrested by cold blood cardioplegic solution. Levels of Gsα and Giα were investigated with Western blot analysis.ResultsNo differences of levels of Gsα and Giα were found in three groups before ischemia ( P gt;0.05). The level of Gsα after ischemia was significantly decreased than before ischemia in groupⅠand group Ⅱ ( P lt; 0 01), whereas no pronounced changes in group Ⅲ ( P gt;0.05) were noted after ischemia. The level of Gsα in group Ⅲ was not significantly changed after reperfusion compared with before ischemia( P gt;0 05), and it was much higher than those in groupⅠand group Ⅱ ( P lt; 0 01). Level of Giα was found not markedly changed in group Ⅲ after reperfusion compared with that before ischemia, but was notable higher in groupⅠand group Ⅱ( P lt;0.01). ConclusionsSignificant decrease of level of Gsα, whereas marked increase of level of Giα are found in myocardium of newborn guinea pig undergoing hypothermic (20℃) ischemic reperfusion. No impact of St. Thomas Ⅱ on these changes is verified, but recovery to the level of Gsα and Giα before ischemia is achieved by cold blood cardioplegic solution after ischemia and reperfusion. Unbalance between Gsα and Giα is the one of the mechanisms of ischemic reperfusion injury for immature myocardium.

    Release date:2016-08-30 06:24 Export PDF Favorites Scan
  • Open heart operation on neonates with critical congenital heart disease 推荐 CAJ下载 PDF

    Objective To summarize the experience of open heart operation on neonates with critical and complex congenital heart diseases and evaluate the methods of perioperative management. Methods From May 2001 to January 2003, 12 patients of neonates with congenital heart diseases underwent emergency operation. Their operating ages ranged from 6 to 30 days, the body weights were 2.8 to 4.5 kg. Their diagnoses included D-transposition of the great arteries in 4 cases, ventricular septal defect with atrial septal defect in 5 cases, complete atrioventricular septal defect, obstructed supracardiac total anomalous pulmonary venous drainage and cardiac rhabdomyomas in 1 case respectively. 12 cases were operated under moderate or deep hypothermic cardiopulmonary bypass. Results All cases were observed in ICU for 2-11 days and discharged 7-19 days after operation. The postoperative complications included low cardiac output, mediastinal infection, respiratory distress syndrome, systemic capillary leak syndrome and acute renal failure. All cases were cured and the follow-up (from 6 months to 2 years) showed satisfactory outcome. Conclusion A particular cardiopulmonary bypass and proper perioperative management is very important to ensure the successful outcome. Peritoneal dialysis is an effective and safe method for treating acute renal failure after cardiac operation in neonates.

    Release date:2016-08-30 06:27 Export PDF Favorites Scan
  • 经胸微创膜部室间隔缺损封堵术围术期炎症因子的变化

    Release date: Export PDF Favorites Scan
  • 上腔静脉右肺动脉分流术治疗三尖瓣闭锁

    目的 总结上腔静脉右肺动脉分流术治疗三尖瓣闭锁(TA)的临床经验。 方法 2004年10月至2008年4月,采用上腔静脉右肺动脉分流术治疗TA 10例,男8例,女2例 ;年龄2~13岁,平均年龄5.6岁;体重10.0~33.5 kg,平均体重16.4 kg。TA合并大动脉错位(右位心)2例,房室间隔缺损3例,永存左上腔静脉1例。均在常温非体外循环下手术,切断上腔静脉,近端缝合,远端与右肺动脉做端侧吻合;1例合并永存左上腔静脉患者行双侧上腔静脉肺动脉吻合术。 结果 全组无死亡患者,术后末梢血氧饱和度由74%±9%上升至92%±5%。所有患者紫绀明显减轻,顺利出院。随访10例,分别随访6~36个月,血氧饱和度86%±3%,活动能力明显改善。 结论 上腔静脉右肺动脉分流术治疗TA效果满意,是比较理想的术式。

    Release date:2016-08-30 05:59 Export PDF Favorites Scan
  • 十字交叉心的外科治疗

    目的 总结4例十字交叉心外科治疗的临床经验,以提高对该病的认识。 方法 2004年3月~2008年1月手术治疗4例十字交叉心患者(平均年龄3.2岁;平均体重10.9 kg)。1例采用心内隧道修补术(intravetricular tunnel rapair IVR),1例采用双向Glenn手术,1例采用双侧双向Glenn术,1例采用IVR+大动脉转位术(arterial switch operation, ASO)。 结果 住院死亡1例,为采用IVR者,死于低心排血量综合征。2例行双向Glenn手术患者术后随访6~12个月,生长发育良好,SpO2 88%左右;1例行IVR+ ASO者,随访6个月,心脏较术前略缩小,生长发育良好。结论 十字交叉心病理解剖复杂,必须根据不同的解剖特点选择不同的手术方法,明确的术前诊断是优化手术方式的先决条件。

    Release date:2016-08-30 06:09 Export PDF Favorites Scan
  • 先天性心脏病心脏不停跳心内直视手术

    摘要 目的 介绍体外循环心脏不停跳下心内直视手术治疗先天性心脏病心内畸形的应用体会。 方法 327例先天性心脏病心内畸形行浅低温体外循环心脏不停跳心内直视手术。常规建立体外循环,置左心房引流管,降温至32±1℃并维持,仅阻断上、下腔静脉,不阻断升主动脉,维持灌注压在60mmHg左右,在心脏不停跳下施行心脏畸形矫正术,方法同心脏停搏手术。 结果 死亡7例,死亡率2.1%,其余均痊愈出院,随访1~13个月,恢复良好。 结论 心脏不停跳下心内直视手术有较好的心肌保护作用,能减少并发症的发生,并简化操作,缩短体外循环时间。

    Release date:2016-08-30 06:33 Export PDF Favorites Scan
  • 体外循环心脏手术病人的视力及视诱发电位观察

    体外循环(CPB)心脏手术后病人的视功能损害,国外已有报道,其主要原因是缺氧、缺血、低温等造成缺血性视神经癍,大脑枕叶病变及视网膜栓塞或梗死所致。我们观察23例患者术前术后的视力及5例患者视诱发电位(visual evoked potential,VEP)的变化。说明CPB心脏手术后可引起或加速缺血性视神经病变的发生和发展;VEP对视功能损害的检查更有价值。 (中华眼底病杂志,1993,9:158-159)

    Release date:2016-09-02 06:35 Export PDF Favorites Scan
  • 58例穿透性心脏损伤的临床分析

    目的分析穿透性心脏损伤(PCT)患者的临床特点以及诊治中应注意的问题。方法对13家医院2002年1月至2004年7月的58例PCT患者的临床资料进行回顾性分析。按急诊时临床表现、损伤结局和术前是否进行辅助检查分为临床型和亚临床型,生存组和死亡组,检查组和未检查组三种不同分组,结合临床数据和创伤评分数据对各组的临床分析进行统计学处理。结果PCT发病率仍较高,刀伤是主要致伤原因。临床型患者入院时循环状况更差,损伤严重度更重;死亡组损伤程度重,院内术前时问短,失血休克型患者死亡率更高;检查组院内术前时间更长,能提供确诊线索的价值有限。结论临床分型对PCT患者的临床救治具有很好的指导作用,辅助检查的作用有限,缩短院内术前时间是提高抢救患者成功率的关键。

    Release date:2016-08-30 06:26 Export PDF Favorites Scan
  • The Affecting Factors on Sinus Rhythms Maintenance after Electric Cardioversion for Atrial Fibrillation in Patients after Cardiac Valve Replacement

    Objective To explore the affecting factors on sinus rhythm maintenance after electric cardioversion for patients with atrial fibrillation (Af) after cardiac valve replacement. Methods One hundred fifty two valvular disease patients with Af after cardiac valve replacement were randomized to 2 groups: Amiodarone group and control group (without anti arrhythmic drugs) after cardioversion. Af recurrence was observed during one year follow up. Results (1) No significant difference of Af recurrence betwe...

    Release date:2016-08-30 06:35 Export PDF Favorites Scan
111 pages Previous 1 2 3 ... 111 Next

Format

Content