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find Keyword "恶性肿瘤" 158 results
  • SEGMENTAL RESECTION OF MALIGNANT TUMOR OF LOWER FEMUR AND REPLANTATION SUBSTITUTION OF THE THIGH BY DISTAL LEG

    T ree cases of sarcomas of theJ we femur were treated by region-a?ir? ation with overdosage of me-chlorethamine for 3 weeks and there-after a high amputation was done,and the distal leg was replantedwith the length that the anklewould act as a knee joint and thefoot pointing backword. Follow-upfor 1 -5 years discovered no me-tastasie of the tumor and the artifi-cial limb showed a better function.

    Release date:2016-09-01 11:41 Export PDF Favorites Scan
  • Effect of facial artery musculo-mucosal flap in reconstructing defects of tongue and mouth floor

    Objective To explore the effect of facial artery musculo-mucosal (FAMM) flap to reconstruct tongue and floor of mouth defects. Methods Between January 2011 and January 2016, 24 cases of tongue and floor of mouth defects were repaired with FAMM flap after tumor resection. There were 16 males and 8 females, aged from 38 to 70 years with an average of 55 years. The disease duration was from 1 week to 6 months with an average of 4 months. The defect located at the floor of mouth in 4 cases, at the tongue in 15 cases, and both tongue and floor of mouth in 5 cases. There were 2 cases of carcinoma at the floor of mouth, 2 cases of adenoid cystic carcinoma at the floor of mouth, 14 cases of carcinoma at the tongue, 1 case of adenoid cystic carcinoma at the tongue, and 5 cases of carcinoma at the tongue and floor of mouth. The size of defect ranged from 4 cm×3 cm to 8 cm×7 cm. Three ipsilateral and 21 contralateral FAMM flaps were harvested (5 cases were repaired with FAMM flap and submental muscle island flap due to the large defect area). The size of FAMM flap ranged from 5 cm×4 cm to 5 cm×5 cm, the size of submental muscle island flap ranged from 4 cm×3 cm to 5 cm×4 cm. Results All flaps survived after operation, without local necrosis. Wound dehiscence at donor site occurred in 5 cases, and healed after cleaning; primary healing was obtained in the other 19 cases. All the patients were followed up 8 months to 5 years with an average of 2 years and 4 months. No obvious facial deformity or fistula of the floor of mouth occurred after operation. Injury of the submandibular branch of the facial nerve was observed in 16 patients, who returned to normal at 3 months. All 24 patients had limitation of mouth opening after operation, which disappeared after 12 months. The functions of speech, chewing, and swallowing were normal. Conclusion FAMM flap has many advantages of simple operation, good repair, high flap survival rate, and less injury at donor site for repairing tongue and floor of mouth defects.

    Release date:2017-04-12 11:26 Export PDF Favorites Scan
  • THE SIGNIFICANCE OF TUMOR SUPRESSOR GENES INACTIVATION IN CARCINOGENESIS OF MULTIPLE PRIMARY NEOPLASM

    Objective To investigate the effect of tumor suppressor gene on tumourigenesis in multiple primary malignant neoplasm (MPMN).Methods The retrospective analysis was used to summarize several common tumor suppressor genes correlation to MPMN. Results At current study of the tumor suppressor genes, the common genes studied in MPMN were p53, APC, p16, BRCA1, BRCA2 and PTEN/MMAC1, etc. The same mutation of tumor suppressor genes could be detected from PMNNs. Conclusion There are significant relations between MPMN and inactivation of tumor suppressor gene. By the study of tumor suppressor gene, it can reveal some common rules of tumourigenesis of MPMN.

    Release date:2016-09-08 02:01 Export PDF Favorites Scan
  • 脾脏原发性恶性肿瘤(附8例报告)

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  • 原发性输卵管肝样腺癌一例

    Release date:2020-04-23 06:56 Export PDF Favorites Scan
  • Mohs Surgery Combining with Plastic Surgery to Treat Craniofacial Cutaneous Malignant Tumors

    目的:探讨头面部皮肤恶性肿瘤采用Mohs手术和整形技术联合应用的治疗效果。方法:37例皮肤恶性肿瘤分为Mohs治疗组12例,普通手术组25例,并对切取肿瘤创面采用肌皮瓣、皮瓣、游离皮片,或直接缝合方式修复。结果: Mohs治疗组病例伤口Ⅰ期愈合,皮瓣全部成活,随访2年无复发。普通手术组病例伤口及皮瓣愈合好,但在2年随访中有4例复发(16%)。结论: Mohs手术和整形技术联合应用是治疗皮肤恶性肿瘤的最佳方法。

    Release date:2016-09-08 10:12 Export PDF Favorites Scan
  • Nuclear Factor-κB and Colon Cancer

    ObjectiveTo explore the relationship between nuclear factor κB (NFκB) and the occurrence, metastasis, and treatment of colon cancer. MethodsThe literature on the structure and the property of molecular biology of NFκB, the relationship between NFκB and apopotosis, malignant tumor and colon cancer were reviewed.ResultsNFκB had action of antiapopotosis. The occurrence of malignant tumor had close relation with the oncogene by NFκB, the metastasis of malignant tumor was that cell of cancer escaped the killing and supervising of immunity by NFκB. NFκB affected the occurrence and metastasis of colon cancer by regulating cmyc, Cox2, ICAM1.Conclusion NFκB has important action in the occurrence and metastasis of colon cancer. It will become a new target of treatment.

    Release date:2016-08-28 04:48 Export PDF Favorites Scan
  • 侧颌颈皮瓣修复颧颞部恶性肿瘤术后软组织缺损

    目的总结应用侧颌颈皮瓣修复颧颞部恶性肿瘤切除术后软组织缺损的效果。 方法2010年10月-2014年2月,应用同侧侧颌颈皮瓣修复颧颞部皮肤癌术后软组织缺损5例。男2例,女3例;年龄50~ 74岁,平均65岁;病程3个月~5年,平均约18个月。肿瘤类型:基底细胞癌2例,鳞癌3例。瘤体位于颧颞相连部位,大小约3.5 cm×2.0 cm~7.0 cm×5.0 cm。病灶切除后皮肤软组织缺损范围为5.0 cm×3.5 cm~8.5 cm×6.0 cm。术中切取皮瓣范围8.5 cm×4.0 cm~12.0 cm×5.0 cm,蒂宽2.5~3.0 cm,长2.0~4.0 cm。 结果术后皮瓣全部成活,供区切口均I期愈合。5例均获随访,随访时间6个月~2年,平均14.5个月。皮瓣色泽与受区皮肤相近;2例因蒂部稍宽,皮瓣蒂端转角有“猫耳朵”凸现,但颜面部外观整体满意。移位皮瓣耐受性好,皮瓣成活、软组织缺损创面完全修复后进一步放疗,放疗后皮瓣无溃疡、坏死。随访期间肿瘤无复发。 结论侧颌颈皮瓣修复颧颞部恶性肿瘤切除后软组织缺损符合整形修复原则,且能耐受进一步放疗,是一种简便、安全、有效的治疗方法。

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  • Application of Ultrasonic Harmonic Scalpel in The Open Surgical Treatment of Gastrointestinal Cancer

    目的 探讨超声刀(ultrasonic harmonic scalpel,UHS)在消化道恶性肿瘤开腹手术中的应用价值。方法 回顾性分析2009年10月至2011年10月期间广西壮族自治区人民医院普通外科-小儿外科收治并由同一手术者进行消化道恶性肿瘤开腹手术的186例患者的临床资料,根据接受手术的种类(UHS开腹手术或传统电刀开腹手术)将其分为UHS组(86例)和传统电刀组(100例),比较2组患者的手术切口长度、手术时间、术中出血量、术后3d引流量、术后住院时间以及住院总费用。结果 UHS组手术切口长度、手术时间、术中出血量以及术后住院时间均短于(少于)传统电刀组(P<0.05);术后3d引流量和住院总费用2组间比较差异均无统计学意义(P>0.05)。结论 将UHS应用于消化道恶性肿瘤开腹手术可获得较好的效果,能提高手术操作的效率,具有很好的应用前景。

    Release date:2016-09-08 10:36 Export PDF Favorites Scan
  • Disease burden and changing trend of respiratory tract malignancies from 1990 to 2021 in China

    ObjectiveTo comprehensively analyze the disease burden of respiratory cancers in China from 1990 to 2021, and predict the trend of disease burden changes from 2022 to 2031, in order to improve its prevention and treatment strategies. MethodsData from the Global Burden of Disease (GBD) 2021 database were extracted and analyzed for the disease burden of nasopharyngeal cancer, laryngeal cancer, and tracheal, bronchial and lung cancers (hereinafter referred to as lung cancer) in China from 1990 to 2021. The Joinpoint 4.9.1.0 software was utilized to analyze the corresponding trends. The grey prediction model [GM (1,1)] was employed to forecast the disease burden of respiratory cancers in China from 2022 to 2031. ResultsThe disease burden of respiratory cancers attributed to tobacco and occupational carcinogens in China raised year by year from 1990 to 2021. Among the respiratory cancers, lung cancer led in terms of incidence, mortality, and disability-adjusted life years (DALY) and their respective age-standardized rates from 1990 to 2021, followed by nasopharyngeal cancer, with laryngeal cancer being the lowest. Analysis via the Joinpoint regression model indicated that, overall, the disease burden of nasopharyngeal and laryngeal cancers in China decreased during this time period, while that of lung cancer increased. From a gender perspective, the disease burden of male patients with nasopharyngeal, laryngeal, and lung cancers was significantly higher than that of female patients from 1990 to 2021. Compared to the global average, the disease burden of respiratory cancers in China from 1990 to 2021 was still relatively heavy. As of 2021, the middle-aged and elderly population above 50 years old was the primary group suffering from the disease burden of respiratory cancers in China. The prediction model showed that the age-standardized rate of nasopharyngeal cancer in China would decline from 2022 to 2031; the age-standardized incidence rate of laryngeal cancer in China would increase, while its age-standardized mortality rate and DALY rate would both decrease; the age-standardized rates of lung cancer in China would all increase. ConclusionIn the past 30 years, the disease burden of nasopharyngeal and laryngeal cancers in China has lightened, but the overall disease burden of lung cancer is still on the rise. Compared to the global average, the disease burden of respiratory cancers in China is still relatively heavy. The disease burden in male patients is significantly higher than that in female patients, and the population above 50 years old is the main group suffering from the disease burden. In the next 10 years, the disease burden of respiratory cancers in China will still tend to increase. Therefore, targeted prevention and treatment strategies for men and the middle-aged and elderly populations remain key challenges that urgently need to be addressed in China's response to respiratory cancers.

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