Objective To observe clinical effects of burn wounds treatment with bovine amnion and to screen the best method of preparing and storing of bovine amnion. Methods From January 2004 to January 2005,We selected randomly 58 patients with superficial Ⅱ° wound, deepⅡ° wound, autografting area for removal of eschars and tangential excision, fetching skin area or residual burn wound . Using auto-control, every burn wound was divided into 3 parts and was treated with 3 dressings: bovine amnion dealt with by 0.1% chlorhexidine（group A）, bovine amnion dealt with by 0.4% glutaraldehyde（group B） and vaseline gauze dressing（group C as control）. The clinical effects were compared between different groupsand the method of preparing and storing bovine amnion was evaluated. Results The dressing texture of group A was softer than that of group B, and its flexibility was fine. The pretreatment was not necessary for dressing in group A. When the dressing was used on burn wounds in groups A and B, painwas slight, but pain was obvious in group C; healing time in groups A and B was much less than that in group C, showing statistically significant difference(P＜0.01). There was no statistically significant difference in healing time between groups A and B (P＞0.05). The infection ratio of burn wound in deepⅡ° wound and residual burn wound of groups A and B is much lower than that of group C, showing statistically significant difference (P＜0.05); in theother burn wounds there was no significant difference (P＞0.05). There was no statistically significant difference between groups A and B (P＞0.05). Conclusion Bovine amnion could make benefit on burn wounds healing, reduce infection ratio of burn wounds, could be used on different kinds of burn wounds. The clinical effect between bovine amnion dealt with by glutaraldehyde and by chlorhexidine is similar. Whereas the latter is more easy to be popularized.
目的 研究银离子联合水凝胶敷料和传统敷料对术后感染伤口的治疗作用。方法 对我院普外科行手术治疗后伤口发生感染的患者进行前瞻性研究，随机纳入新型敷料组（银离子联合水凝胶）和传统敷料组，收集患者一般基线资料，比较2组的创面愈合率、创面愈合时间及换药费用。结果 根据纳入和排除标准，最终新型敷料组纳入42例患者，传统敷料组纳入58例患者，2组患者基线资料一致（P＞0.05）。治疗6d后的创面愈合率新型敷料组明显高于传统敷料组（P＜0.05）；创面愈合时间新型敷料组明显短于传统敷料组（P＜0.05）；换药费用2组间比较差异无统计学意义（P＞0.05）。结论 银离子联合水凝胶敷料具有较好的控制伤口感染、促进伤口的生长及促进伤口愈合的作用。
Skin trauma is a global public health issue, and chronic wound healing is complex. Its care faces problems such as long cycles and poor outcomes. In recent years, research on novel wound dressings and nursing methods has gradually increased, but there is still a lack of systematic summary of nanomaterials dressings for repairing chronic skin wounds. This article reviews the application and nursing effects of nanomaterials dressings in chronic wound repair, explores their potential, and looks forward to the research directions of chronic wound prevention, science popularization, and service system construction, providing a reference for the clinical application of nanomaterials.
Three-dimensional (3D) printing is a low-cost, high-efficiency production method, which can reduce the current cost and increase the profitability of skin repair material industry nowadays, and develop products with better performance. The 3D printing technology commonly used in the preparation of skin repair materials includes fused deposition molding technology and 3D bioprinting technology. Fused deposition molding technology has the advantages of simple and light equipment, but insufficient material selection. 3D bioprinting technology has more materials to choose from, but the equipment is cumbersome and expensive. In recent years, research on both technologies has focused on the development and application of materials. This article details the principles of fused deposition modeling and 3D bioprinting, research advances in wound dressings and tissue engineering skin production, and future developments in 3D printing on skin tissue repair, including cosmetic restoration and biomimetic tissue engineering. Also, this review prospects the development of 3D printing technology in skin tissue repairment.
目的 探讨瘢痕或皮肤肿瘤切除后创面使用皮能快愈敷料（PELNAC，商品名：皮耐克）结合自体刃厚皮覆盖的治疗效果。 方法 回顾分析2010年1月－2013年1月收治的两组瘢痕或皮肤肿瘤切除术后创面分别使用不同皮片覆盖的治疗效果。A组6例，采用PELANC与自体刃厚皮片复合移植；B组10例，采用自体中厚皮片移植修复。随访近期、远期，对比评估两组创面存活的皮片外观，弹性；供皮区愈合情况。 结果 两组患者皮片完全成活，外观好，弹性佳，较术前明显改善。与B组相比，A组供皮区愈合时间短，愈合后色素沉着轻微，无明显疤痕形成。 结论 采用PELNAC与自身刃厚皮片复合移植修复瘢痕或肿瘤切除后创面，既能够显著改善外观、功能，达到理想的创面修复效果，又不会造成供皮区的继发性瘢痕增生，是一种理想的创面修复方式。
目的 观察AQUACEL-Ag®亲水性纤维敷料对肛周脓肿患者术后创面愈合的作用。方法 将49例肛周脓肿术后患者按随机数字表法随机分为试验组（25例）和对照组（24例），分别予AQUACEL-Ag®亲水性纤维敷料换药（1 次/3d）和无菌凡士林纱布换药（1次/d），并观察2组患者的换药时创面疼痛程度、创面愈合时间、创面换药次数、创面愈合率及换药时创面分泌物培养结果。结果 试验组在创面疼痛、愈合时间、创面换药次数及换药时分泌物培养转阴时间方面均优于对照组（P＜0.05）；动态监测创面愈合率：第3d时2组间比较差异无统计学意义（P＞0.05），第9、15、21d时试验组创面愈合率明显高于对照组（P＜0.05）。结论 从本组有限的数据看，AQUACEL-Ag®亲水性纤维敷料对肛周脓肿患者术后创面愈合有重要作用。