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Advance in Study of MicroRNA in Invasion and Metastasis of Breast Cancer

ObjectiveTo summarize the relationship of microRNA (miRNA) to metastasis and invasion of breast cancer. MethodDomestic and international publications involving the relationship of miRNA to breast cancer were screened and reviewed. ResultsmiRNA played a key role in the process of breast cancer metastasis. According to its function, it could be distinguished from cancer-promoting gene (such as miR-21, miR-10b, etc.) to suppressor gene (such as miR-31, let-7, etc.). ConclusionThe more detailed experimental studies about the relationship of miRNA to metastasis and invasion of breast cancer need to be researched in order to provide a new method for the diagnosis and treatment of breast cancer metastasis and invasion.

Targeted Therapies in Fontan Patients Due to Single Ventricle:Recent Advances

The success of staged Fontan palliation for patients with single ventricle is related to low pulmonary vascular resistance (PVR). The complications of high PVR in Fontan physiology are numerous, such as low exercise tolerance, low cardiac output, ventricular function failure and protein-losing enteropathy; eventually it leads to failing Fontan. Therefore, a low PVR is crucial in Fontan patients. Now, targeted therapies decreasing PVR has been an advanced research hotspot in Fontan patients. In this review we present an overview of the safety and efficacy of the therapy with bosentan or sildenafil on elevated pulmonary artery pressure and pulmonary vascular resistance in Fontan patients.

可吸收螺钉改良Dewar术治疗陈旧性Ⅲ度肩锁关节脱位

Epidemiological characteristics and progress in diagnosis and treatment of esophageal cancer with human immunodeficiency virus/acquired immune deficiency syndrome

Human immunodeficiency virus (HIV) infection mainly attacks the human immune system, causing a variety of opportunistic infections and tumors, among which neoplastic diseases are serious and life-threatening. In recent years, with the popularization of highly effective anti-retroviral virus, the disease spectrum of HIV infected people has changed greatly, the incidence of non-acquired immune deficiency syndrome (AIDS) related tumors has increased significantly, and the diagnosis rate of esophageal cancer patients with HIV/AIDS has also increased. However, there is no consensus on how to standardize the diagnosis and treatment of esophageal cancer patients with HIV/AIDS. This article reviews the epidemiological characteristics, diagnosis and treatment of esophageal cancer patients with HIV/AIDS.

碱性成纤维细胞生长因子促进人血管内皮细胞αv整合素的表达及意义

获得性免疫缺陷综合征合并巨细胞病毒视网膜炎的高效抗逆转录病毒治疗

高效抗逆转录病毒治疗（HAART）能重建机体对巨细胞病毒（CMV）在内的许多病原的免疫反应，不仅可以减少包括CMV视网膜炎在内的CMV感染性疾病的危险，还可以延长获得性免疫缺陷综合征患者的生存期，提高生存率。但有必要加强HAART期间患者的免疫重建炎症综合征的监护。

咳嗽, 活动后气促, 左肺大片致密影

钩钢板治疗锁骨外侧端骨折伴肩锁关节脱位

超声造影与 MRI 增强扫描在高强度聚焦超声治疗子宫肌瘤中的疗效监测

目的 比较超声造影（contrast-enhanced ultrasound，CEUS）与 MRI 增强扫描在高强度聚焦超声（high intensive focused ultrasound，HIFU）治疗子宫肌瘤中的疗效监测作用。 方法 选取 2013 年 1 月—2014 年 12 月采用 HIFU 治疗的 179 例子宫肌瘤患者（共 234 个肌瘤），对治疗前肌瘤体积及治疗后非灌注区肌瘤消融体积分别采用 CEUS 和 MRI 增强扫描检查。 结果 CEUS 和 MRI 增强扫描在治疗前肌瘤体积对比中差异有统计学意义（P<0.05），在治疗后非灌注区肌瘤消融体积对比中差异无统计学意义（P>0.05）。对治疗后残留两者均可有效检出。 结论 CEUS 和 MRI 增强扫描在 HIFU 治疗前都是治疗必须的检查，两者不可替代；两者均是治疗后疗效评价的有效方法，但 CEUS 比 MRI 增强扫描在治疗中更具灵活性、可重复性，在一定程度上可替代 MRI 增强扫描。

传染病医院保洁人员感染知识知晓程度调查与分析

目的了解保洁员对感染知识的掌握情况。 方法2012年3月－5月结合《医院感染管理办法》和《消毒技术规范》的部分章节及相关参考文献，采用自行设计的调查表，对52名保洁员的职业防护知识进行不记名问卷调查。 结果保洁员对感染知识缺乏，六步洗手法的知晓率仅为30.7%；摘手套后洗手的执行率为21.1%；工作中坚持戴口罩者仅占28.9%。 结论保洁员在日常工作中存在较为严重的医院感染隐患，应采取适合的培训方法，加大对保洁员的培训力度，加强对其工作过程的监督与管理，提高工作质量，有效控制医院感染。