Primary bronchopulmonary carcinoma occurs in the bronchial mucosa epithelium, also called lung cancer (LC), and has currently become the first cause of death of malignant tumors in China. With constant efforts of Chinese physicians, the diagnosis and management of LC has made certain progress, but standardized surgery for LC still varies to a great extent due to difference regions, nature of medical centers, and technical levels. Complete and standardized surgical resection can provide good long-term survival for patients with stageⅠ, Ⅱand partly ⅢA LC, and cannot be a substitute for other treatment, which shows the importance of standardized surgery. As the most solid member, surgery plays a decisive role in comprehensive multidisciplinary treatment of LC. Today's medical development requires thoracic surgeons to provide most standardized and individualized treatment with principles of evidence-based medicine. This review focuses on progress of standardized surgery for stage Ⅰto ⅢA LC.
【Abstract】Objective To study the surgical therapy and staging investigation about stage Ⅳ breast carcinoma. Methods The clinical data of 38 patients with stage Ⅳ breast carcinoma were summarized, and the patients were followed up. Results The stage Ⅳ patients who had isolated metastasis and removable primary tumor were treated by radical surgery with good effect. On the other hand, the stage Ⅳ patients who had extensive metastasis and primary tumor unresectable were treated by palliative operation with the living quality of patients becoming better and chemotherapy load cutting down. Conclusion The stage Ⅳ patients should be divided into stage Ⅳa and stage Ⅳb. And the stage Ⅳa patients should be treated by radical operation, and the stage Ⅳb by palliative operation.
目的 探讨十二指肠球部远端溃疡的诊断和选择合适的手术治疗。方法 对我院25例十二指肠球部远端溃疡的临床资料进行了分析。结果 术前行上消化道X线钡餐检查8例，提示十二指肠球部溃疡4例，幽门梗阻2例； 纤维胃镜检查9例，发现十二指肠球部远端溃疡7例。术前确诊7例，误诊18例。20例曾行非手术治疗，但效果差，并出现溃疡并发症，如出血、穿孔、梗阻性黄疸、胆囊内瘘、幽门梗阻、急性胰腺炎等。本次手术治愈25例，1例术后9天并发输入、输出襻粘连性肠梗阻，经再次手术而愈。结论 纤维胃镜检查是诊断本病的主要方法，手术是该病的重要治疗措施。
Objective To understand breast cancer 1 (BRCA1) gene and relationship between BRCA1 gene and breast cancer, and analyze its effect on clinical comprehensive therapy of breast cancer. Method The domestic and international studies relevant BRCA1 and breast cancer in recent years were reviewed and summarized. Results BRCA1, a tumor suppressor gene, its mutations caused structural changes and functional abnormalities, which were closely related to breast cancer. And the expression situation and mutation of BRCA1 were associated with the therapeutic effect. Conclusions Mutation of BRCA1 is closely related to occurrence and development of breast cancer in female. Comprehensive therapy ideas should be found in clinical therapy according to expression or mutation of BRCA1. Further research on BTCA1 is beneficial to explore gold standard for treatment of breast cancer.
目的总结十二指肠损伤的诊断和治疗经验。方法对我院1989年1月至2003年7月期间收治的13例十二指肠损伤患者的临床资料进行回顾性分析。本组均经手术治疗，行十二指肠单纯修补术6例，十二指肠憩室化手术1例，改良憩室化术4例（3例缝扎十二指肠），Roux-en-Y吻合术1例，T管引流及脓肿切开引流术1例。结果治愈11例； 死亡2例, 其中1例死于十二指肠瘘，另1例死于肝功能不全。结论十二指肠损伤的早期诊断和手术处理非常重要； 缝扎十二指肠的改良憩室化手术是治疗重症十二指肠损伤的一种较理想术式。
Objective We intended to get good understanding of the current role of imatinib （or glivec） in the treatment of a patient with chronic-phase chronic myeloid leukemia. Methods We attempted to find the current best evidence of imatinib for treating chronic myeloid leukemia in chronic phase by searching ACP Journal Club （1991 -Jun, 2005 ）, The Cochrane Library（Issue 2, 2005 ）and MEDLINE（1990 -Jun, 2005 ） and further critically appraised the available evidence. Results Imatinib appeared to be more effective than current standard drag treatments in terms of hematologic and cytogenetic response with better quality of life and fewer side effects. However, there was uncertainty concerning long term outcomes. Given the current evidence together with our clinical experience and considering the patient and his family members＇ values and preference, imatinib （400 mg qd） was administered to him. No obvious adverse effects occurred with 3 months follow-up. Conclusions Imatinib is effective and well tolerated in the treatment of chronic myeloid leukemia in chronic phase. Further researches on long-term follow-up data from imatinib trials are definitely needed.
目的:探讨婴儿肝炎综合征临床表现、治疗及护理。方法:对我院收治的260例婴儿肝炎综合征临床表现、治疗及护理进行回顾性分析、总结。结果:70例患儿痊愈出院,175例患儿好转出院,11例患儿经保肝治疗后肝功能及一般情况逐渐变差自动出院,4例于医院因肝功能衰竭死亡。结论:婴儿肝炎综合征住院时间长,治疗及护理的配合非常重要。