To analyze the adverse drug reactions (ADRs) induced by levetiracetam, providing a scientific basis and reference for clinical safe and rational drug use.Using Chinese search terms such as "levetiracetam", " antiepileptic", "adverse drug reaction", "side effect", and English search terms such as "levetiracetam", "antiepileptic", "adverse reaction", "ADR", "side effect", and "induced", we conducted a literature search in databases including CNKI, Wanfang Data, VIP Biomedical Database, PubMed, and Web of Science from the inception of the databases until March 1, 2025. Relevant information was extracted and statistically analyzed. A total of 39 articles were included, involving 46 patients, of which 24 were male (52.17%) and 22 were female (47.83%). ADRs involved 9 organ/systems, primarily the nervous system (39.13%), muscular system (32.61%), skin (13.04%), and urinary system (10.87%), including symptoms such as irritability, hallucinations, cognitive impairment, rhabdomyolysis, papules, and frequent urination. ADRs induced by levetiracetam affect multiple organ/systems. During clinical use, patient conditions should be regularly monitored, and the dosage should be promptly reduced or discontinued upon the occurrence of adverse reactions to mitigate clinical risks.