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find Keyword "眼" 1035 results
  • Vitreous surgery for severe ocular trauma

    Objective To summarize the visual outcome of patients with severe ocular trauma treated with vitreous surgery. Methods Clinical data of 188(191 eyes) with severe ocular trauma treated with vitreous surgery in a period from November 1996 to April 1998 were analysed retrospectively. Results The study included penetrating injury in 56 eyes, foreign bodies in the posterior segment in 70 eyes, blunt injury in 41 eyes , and globe rupture in 24 eyes. Main complications included endophthalmitis in 35 eyes, choroidal bleeding in 20 eyes, retinal detachment in 60 eyes, and vitreous hemorrhage in 97 eyes. Post-opera-tively, out of 188 eyes, except for 3 of patients too young to examine, visual acuity improved in 133(70.7%), including 85(45.2%) with visal acuity 0.02-1.0, 46(24.5%) remained unchanged; and 9(4.8%) had worse vision. Among 34 with no-light-perception, 12 had light-perception or over. Conclusion A majority of severe trauma eyes can be salvaged with considerable visual recovery after adequate and timely vitreous surgery. (Chin J Ocul Fundus Dis,1999,15:4-6)

    Release date:2016-09-02 06:08 Export PDF Favorites Scan
  • Clinical histopathological and misdiagnostic analysis of 359 cases of intraocular tumors

    Objective To probe the clinical character,the histopathological classification and misdiagnoses of intraocular tumors. Methods The clinical and pathological data of 359 patients with intraocular tumor diagnosed clinically between 1980~2000 were retrospectively analyzed. Results There were 300 cases of malignant tumor and 23 cases of benign tumor respectively. Non-oncologic malady and benign tumor misdiagnosed as tumor or malignant tumor were 40 cases. The two leading malignant tumors were retinoblastoma and melanoma. Conclusion The clinical and pathological analysis of intraocular tumor is beneficial to the correct clinical diagnosis and treatment. (Chin J Ocul Fundus Dis,2002,18:28-30)

    Release date:2016-09-02 06:01 Export PDF Favorites Scan
  • CORRECTION OF ENOPHTHALMOS DEFORMITY CAUSED BY ORBITAL BLOW-OUT FRACTURES USINGMEDPOR IMPLANTATION

    Objective To study the surgical reconstruction for correction of enophthalmos deformity caused by orbital blowout fractures. Methods From December 1996 to March 2004, 56 cases of enophthalmos deformity caused by orbital blow-out fracture were repaired. There were 37 cases diplopia, 35 cases with worsened visual acuity than pretrauma. Typical sub-ciliary incision was employed to expose the fractured area.The dissection was done beneath the medial and inferior obital periosteum. The fracture areas were exposed and the tissues protrusing to sinus maxillaries were released through the space between fractural bones. After the medial and inferior orbital walls and orbital floors were exposed,the herniated orbital contents were released and reduced to the orbital cavity. The fractured orbital walls were repaired precisely with Medpor which were fixed to the area beneaththe periosteum with 2 plates at least. Results All 56 cases ofenophthalmos deformity caused by orbital blow-out fracture repaired with this technique recovered well and their facial appearance improved greatly. With a follow-up ranged from 2 months to 5 years, the degree of enophthalmos stabilized at within 2 mm, no relapse and other complications occurred. Of 34 patients with diplopia, 27 were improved. Of the 35 cases with worsened visual acuity, 9 were improved with different degree. No diplopia or visual acuity worsening occurred. Conclusion It is safe and effectiveto correct the orbital blow-out fractures. The earlier it is repaired, thebetter the effect will be. Medpor with its advantages like better histocompatibility, easier sculpturing, moderate hardness, lower absorptivity, fewer complications and permanence effect is the preferable implantation material for correcting enophthalmos deformity.

    Release date:2016-09-01 09:29 Export PDF Favorites Scan
  • The protective effects of heat-shock response on the retinae of rats after retinal ischemic reperfusion injury

    Objective To analyze the protective effects of heat-shock response on the retinae of the rats after retinal ischemic reperfusion injury.Method Twenty Wistar rats (20 eyes) were divided into 4 groups: intracameral perfusion group (group P), intracameral perfusion after quercetin injection group (group P+Q), intracameral perfusion after heat shock group (group P+H), and in tracameral perfusion after quercetin injection and heat shock group (group P+Q+H ). According to the standard program established by International Society for Clinical Visual Electrophysiology, we recorded the results of the dark-adapted electroretinogram (D-ERG ),oscillatory potentials (OPs),and light-adapted ERG (L-ERG) of the rats with intraocular hypertension after induced by heat shock response. The expressions of HSP 70 of the rats in all groups were observed by Western blotting.Results The expression of HSP 70 of the rats in group P+H was the highest in all groups, but the expressions of HSP70 in group P+Q and P+Q+H were inhibited significantly. The amplitudes of a and b wave of ERG and O2 wave of OPs decreased, and the delitescence of them were delayed significantly in rats after intracameral perfusion. The amplitude of b wave of D-ERG and O2 wave of OPs in group P+H were higher than which in group P. Zero hour after perfusion, the amplitudes of all waves in group P+H increased significantly (Plt;0.05). Twenty-four hours after perfusion, the retinal functional resumption of the rats in group P+H was better than which in group P. In group P+Q and P+Q+H, the delitescences of all waves of ERG and O2 wave of OPs were the longest and the amplitudes were the lowest, and some waves even disappeared.Conclusions The heat-shock response may improve the recovery ability of the retinal cells after injury of ischemic reperfusion.(Chin J Ocul Fundus Dis,2003,19:117-120)

    Release date:2016-09-02 06:00 Export PDF Favorites Scan
  • Inhibitive effect of E2F decoy oligodeoxynucleotide on proliferation of human retinal pigment epithelial cells in vitro

    Objective To investigate the inhibitive effect of E2F decoy oligodeoxynucleotides (E2F decoy ODNs) on cultured human retinal pigment epithelial (HRPE) cells.Methods E2F decoy ODNs or scramble decoy ODNs at varied concentrations were put into the HRPE cells mediated by lipofectamineTM2000. The proliferative activity of HRPE was detected by methythiazolyl-terazollium assay, and the competitive combinative activity of E2F decoy ODNs and transcription factor E2F was detected by electrophoresis mobility-shift assay. Results The proliferation of HRPE was inhibited markedly by E2F decoy ODNs at the concentration of 0.2 μmol/L (P=0.002) in a dose-dependent manner but not by scrambled decoy. The results of electrophoresis mobility-shift assay showed that the combinative activity of transcription factor E2F was abolished completely by E2F decoy ODNs. Conclusions E2F decoy ODNs may sequence-specifically inhibit the combinative activity of transcripti on factor E2F,and inhibit the proliferation of HRPE cells.(Chin J Ocul Fundus Dis,2004,20:182-185)

    Release date:2016-09-02 05:58 Export PDF Favorites Scan
  • 慢性重度苯中毒致眼底出血三例

    Release date:2016-09-02 06:00 Export PDF Favorites Scan
  • 视网膜色素上皮细胞凋亡相关疾病的治疗现状及展望

    细胞凋亡是生理或病条件下的一种由遗传基因控制的细胞主动死亡形式,对维持机 体的正常发育以及内环境的稳定起重要作用。细胞凋亡平衡的破坏可导致多种疾病的发生发 展。现介绍基因治疗、细胞因子或生长因子、视网膜移植对视网膜色素上皮(retinal pigme nt epithelial,RPE)细胞凋亡所致疾病的治疗现状及前景。 (中华眼底病杂志,2001,17:82-83)

    Release date:2016-09-02 06:03 Export PDF Favorites Scan
  • Bibliometrical analysis of domestic and international publications in neuro-ophthalmology

    Purpose To analyze the contents of domestic and inter national public ations in neuro-ophthalmology during the past decade. Methods CBM and Medline were separately searched in 2007, by using Medical subject heading for retrieving Chinese and English language neuro-ophthalmic articles which were published between 1997 and 2006. Results A total of 13052 Englishwritten a rticles available for analysis were contributed from more than 70 countries, mainly from USA, United Kingdom, Japan, Germany, Italy and Canada. The order of frequency was visual cortex(4496/13052,34.4%),optic nerve diseases(3870/13052,29.7%),ocular mo tility disorders(2899/13052,22.2%),visual pathway(1191/13052,9.1%)pupil dis orders(596/13052,5.6%). While a total of 3726 articles were retrieved from CBM, the order of frequency being optic nerve diseases(1854,49.8%),ocular motili ty disorders(excluding strabismus, 1357,36.4%),pupil disorders (242, 6.5%),visual cortex(202, 5.4%), visual pathway(excluding retina, optic nerve, visual cortex, 71). Researchers with diverse specialties contributed to the neuro-ophthalmic publications. Compared with international counterpart, domestic articles relate d to basic researches were much less. Conclusion Neuro-ophtha lmoloy is interdisc iplinary with a wide range of researches and various study hotspots. Domestic basic researches on neuro-ophthalmology remain to be strengthened and improved. (Chin J Ocul Fundus Dis,2008,24:99-102)

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • CRYOPRESERVATION OF HUMAN RETINAL PIGMENT EPITHELIAL CELLS AND CULTURE FROM THAWING OF FROZEN CELLS

    PURPOSE:To establish methods for cryopreservation of human retinal pigment epithelial cells (RPEs)and cell culture from thawing of frozen cells. METHODS:Primary cultured RPEs or its first or second passages,added with 10 dimetbylsulfoxide,were kept in --20℃ for 1 to 2 hours,and then further froze to -40~C over night before being placed in liquid nitrogen. The frozen cells were thawed in 60℃ within 2 minutes. Trypan blue staining and immunocytochemical staining with anti-human keratin were performed for cell viability and differentiation. The growth curve was also determined by calculating the total number of cells/well/day. RESULTS:The viable rate from frozen RPEs was 90%. No differences were observed for growth activity between cultures from frozen cells and controls. The cells were positive with anti-human keratin staining. The logarithmic growth phase was during I to 4 days and the doubling time yeas 1.55 days. CONCLUSION: Cryopreservation of RPEs in liquid nitrogen can maintain biological activities of cells with normal growth and features after thaw- ing. This will provide cell lines for in vitro experiments and possibly for cell banks for RPE transplantation for some fundus diseases. (Chin J Ocul Fundus Dis,1997,13:157-159)

    Release date:2016-09-02 06:12 Export PDF Favorites Scan
  • 睡眠对癫痫及癫痫发作的影响

    癫痫是由多种原因导致的脑部神经元高度同步化异常放电所致、以具有持久性的致痫倾向为特征的脑部疾病。越来越多的研究证实,睡眠与癫痫具有十分紧密的关系,睡眠觉醒节律对癫痫发作及发作间期痫样放电有显著影响。不同类型癫痫及癫痫发作有着不同的昼夜节律,额叶癫痫较颞叶癫痫更易在睡眠中发作,但颞叶癫痫更易在睡眠中继发全面性发作。此外,不同类型癫痫发作会在特定的睡眠时相而增多,部分性发作及部分继发全面性发作在非快速动眼期睡眠明显增多,特别是在2期睡眠,而在快速动眼期睡眠则很少出现。非快速动眼期睡眠会促进发作间期痫样放电的发生,相反,快速动眼期睡眠则会抑制发作间期痫样放电的传播,进而限制其脑区的分布范围,从而有利于临床中对致痫灶的定位。

    Release date:2019-03-21 11:04 Export PDF Favorites Scan
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