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AN EXPERIMENTAL STUDY OF BONE GRAFTS NOURISHED BY VENOUS BLOOD

The paper introduced bone graft nourished by venous blood, compared with vascularized and conventional bone graft in the animal experiment. B、h(?)ological, radiological methods and tatracycline labeling, the results confirmed that the bone gra(?) nourished by venous blood is inferior to the vascularized bone graft, but is significantly superior to the conventional bone graft in the survival amount, vitality of osteocytes and bone union. The survival mechanism and practicality of bone graft nourished by venous blood were preliminarily discussed in the paper.

TRANSPLANTATION OF THE CUTANEOUS ILIAC FLAP FOR THE REPAIR OF BONE AND SOFT TISSUE DEFECT OF METATARSAL

Objective To investigate the effect of transplantation of the cutaneous iliac flap on repairing bone and soft tissue defect of metatarsal. Methods From October 1999 to December 2003, the cutaneous iliac flap was designed for the repair of bone and soft tissue defect of metatarsal in 4 male patients, whose ages ranged from 26 to 47, with skin graft for the coverage of the iliac flap. The duration of injury ranged from 1 to 5 months. The length of the defect ranged from 4 to 7 cm and the defect area ranged from 5 cm×3 cm to 9 cm×5 cm. Results One week after transplantation, complete survival of iliac flap was observed in 3 cases and partial survival in 1 case (but later proved survived). Callus was seen 1 month after transplantation and Kwires were removed 4months after transplantation. Patients were followed up for 5 to 24 months. There were no ulcers. The ability of walking and bearing was satisfying as well asthe function and shape. Conclusion With satisfying restoration of function and shape, transplantation of the cutaneous iliac flap with skin graft is an alternative to treat bone and soft tissue defect of metatarsal with one stage surgery.

COMPARATIVE STUDY ON GRAFT OF AUTOGENEIC ILIAC BONE AND TISSUE ENGINEERED BONE

OBJECTIVE: To compare the clinical results of repairing bone defect of limbs with tissue engineering technique and with autogeneic iliac bone graft. METHODS: From July 1999 to September 2001, 52 cases of bone fracture were randomly divided into two groups (group A and B). Open reduction and internal fixation were performed in all cases as routine operation technique. Autogeneic iliac bone was implanted in group A, while tissue engineered bone was implanted in group B. Routine postoperative treatment in orthopedic surgery was taken. The operation time, bleeding volume, wound healing and drainage volume were compared. The bone union was observed by the X-ray 1, 2, 3, and 5 months after operation. RESULTS: The sex, age and disease type had no obvious difference between groups A and B. all the wounds healed with first intention. The swelling degree of wound and drainage volume had no obvious difference. The operation time in group A was longer than that in group B (25 minutes on average) and bleeding volume in group A was larger than that in group B (150 ml on average). Bone union completed within 3 to 7 months in both groups. But there were 2 cases of delayed union in group A and 1 case in group B. CONCLUSION: Repair of bone defect with tissue engineered bone has as good clinical results as that with autogeneic iliac bone graft. In aspect of operation time and bleeding volume, tissue engineered bone graft is superior to autogeneic iliac bone.

踝关节牵张术联合同种异体骨软骨移植治疗距骨骨软骨损伤一例

THE USE OF DEEP-FREEZING ALLOGRAFT IN REVSION TOTAL HIP REPLACEMENT

fter total hip replacement ,massive bone defect occured freqently due to wearing and loosening of the prcathesis.The use of deep-freezing allograft to su pport a new implant was an attractive solution. Deep-freezing decreased the immune antigenicity of the transplanted allograft.From 1972 to 1990. the deep-freezing allografts were used in rcvision total hip replacement in 212 cases,in which 187 cases(198 hips) were followed-up for over 1 year.The general effective rate was 85%....

TREATMENT OF OSTEONECROSIS OF FEMORAL HEAD BY CORE DECOMPRESSION COMBINING WITH AUTOLOGOUS CORTICAL SUSTAINING BONE AND CANCELLOUS BONE GRAFT

Objective To study the effect of core decompression combining with autologous cortical sustaining bone and cancellous bone graft in treating osteonecrosis of the femoral head (ONFH). Methods From February 2004 to May 2008, 64 patients (77 hi ps) with ONFH were treated with core decompression combining with autologous cortical sustaining bone and cancellous bone graft, including 45 males and 19 females and aging 23 to 60 years with an average age of 43 years. There were 51 cases of unilateral ONFH and 13 cases of bilateral ONFH. ONFH was caused by alcohol in 39 cases(47 hi ps), by steroid in 21 cases (26 hi ps), and by trauma in 4 cases (4 hi ps). The disease course was 1-12 years. The pain time was 2-14 months (average 7 months). All the cases underwent imageology and postoperation pathology examination to confirm the diagnosis of ONFH. According to Association Research Circulation Osseous (ARCO) international classification of osteonecrosis, 17 cases (23 hips) were classified as stage I A, 2 cases (3 hips) as stage I B, 21 cases (24 hips) as stage II A, 2 cases (2 hips) as stage II B, 4 cases (4 hips) as stage II C, and 18 cases (21 hips) as stage III A. The outcome was evaluated both cl inically by Harris score and radiologically by imageology. Results A total of 59 cases (69 hips) were followed up for 12-62 months with an average of 32.1 months. The Harris score was 87.12 ± 8.68 at 12 months after operation, showing significant difference (P lt; 0.05) when compared with the preoperative one (68.38 ± 14.49). The results were excellent in 39 hips, good in 18 hips, fair in 6 hips, and poor in 6 hip; and the excellent and good rate was 82.6%. Radiographic evaluation was 21 hips (30.4%) of grade I, 42 hips (60.9%) of grade II, and 6 hips (8.7%) of grade III. One case had the compl ication of il ium bone donor site, 21 cases had l ittle pain or numbness, and the other cases had no uncomfortable compl ication. Conclusion The method of core decompression combining with autologous cortical sustaining bone and cancellous bone graft can improve the means of bone grafts, prevent the collapse of the femoral head, and is less traumatic than common procedures. Cl inical effects are obvious and effective.

关节镜下自体骨软骨移植修复软骨缺损

【摘 要】 目的　总结关节镜下自体骨软骨镶嵌移植术（osteochondral autologous transplantation，OAT）修复膝关节软骨缺损的方法及临床效果。 方法 2000 年8 月－ 2005 年6 月，采用关节镜下OAT 治疗23 例股骨髁关节软骨缺损。男15 例，女8 例；年龄16 ～ 41 岁。运动冲撞伤13 例，跌伤2 例，8 例无明显诱因或外伤史。病程1 ～ 8 个月。软骨缺损深度按照国际软骨修复协会标准分级：4 级15 例，3 级8 例。缺损范围2.0 ～ 4.0 cm2。Lysholm 评分（69.54 ± 12.36）分。 结 果 术后切口Ⅰ期愈合。15 例获随访，随访时间24 ～ 48 个月，平均33 个月。术后6 个月12 例关节症状完全消失；2 例剧烈活动后关节出现肿胀，1 例上下楼梯时前膝偶有酸痛不适，经对症治疗后痊愈。术后24 个月Lysholm 评分（94.15 ± 9.21）分，与术前比较差异有统计学意义（P lt; 0.05）。 结论 关节镜下OAT 创伤小、能恢复关节面的曲度，是治疗小面积软骨缺损有效方法之一。

带旋髂深血管蒂髂骨及髂骨膜瓣移位治疗中青年股骨颈骨折

目的 总结带旋髂深血管蒂髂骨及髂骨膜瓣移位治疗中青年股骨颈骨折的手术方法及临床疗效。 方法 2003 年4 月－ 2007 年3 月，收治22 例中青年股骨颈骨折患者。男12 例，女10 例；年龄25 ～ 53 岁，平均42 岁。均为闭合性骨折。致伤原因：交通事故伤18 例，高处坠落伤4 例。受伤至手术时间5 h ～ 43 d。新鲜骨折20 例，陈旧性骨折2 例。骨折部位分型：头下型10 例，经颈型12 例。骨折Garden 分型：Ⅲ型6 例，Ⅳ型16 例。术前Harris 髋关节功能评分（22.80 ± 8.75）分。采用带旋髂深血管蒂髂骨及髂骨膜瓣移位加空心加压螺钉治疗。 结果 术后1 例供区伤口伴液化渗出，经换药治愈；其余切口均Ⅰ期愈合。术后患者均获随访，随访时间20 ～ 60 个月，平均42 个月。21 例股骨颈骨折愈合，愈合时间3 ～ 6 个月，平均3.5 个月；1 例骨折不愈合并股骨头缺血性坏死，于术后6 个月行人工全髋关节置换术。术后14 个月Harris 评分为（86.40 ± 7.95）分，与术前比较差异有统计学意义（P lt; 0.05）。 结论 带旋髂深血管蒂髂骨及髂骨膜瓣治疗中青年股骨颈骨折可改善骨折端血运，促进骨折愈合，减少股骨头坏死的发生。

Effectiveness of free vascularized fibular graft for bone defect after resection of lower limb malignant tumor

Objective To analyze the effectiveness of free vascularized fibula grafts (FVFG) for extensive bone defects after resection of lower limb malignant bone tumors. Methods Between November 2015 and July 2018, 15 cases of lower limb malignant bone tumors were treated. There were 12 males and 3 females with an average age of 12.3 years (range, 9-21 years). There were 11 cases of osteosarcoma and 4 cases of Ewing’s sarcoma. The tumor located at middle femur in 8 cases, lower femur in 4 cases, and middle tibia in 3 cases. The disease duration was 2-6 months (mean, 3.2 months). The tumor was completely removed, and the length of the bone defect was 8-23 cm (mean, 17.7 cm). The bone defect was repaired by FVFG, and combined inactivated tumor bone was used in 8 cases of femoral bone defect. Results The average operation time was 280 minutes (range, 180-390 minutes). The average blood loss was 310 mL (range, 200-480 mL). All incisions healed by first intention. All patients were followed up 2-24 months with an average of 14.5 months. Bone healing achieved in all patients at 9-18 months (mean, 12.3 months) after operation except 1 patient which was followed up only 2 months. The fibula grafts had active metabolism and the average bone metabolism score was 184 (range, 111-257) in effected side and 193 (range, 127-259) in contralateral side. There was no difference between bilateral sides. The average Enneking score was 24.6 (range, 20-30) at last follow-up. No ankle instability or paralysis of common peroneal nerve occurred. Conclusion FVFG appeared very efficient in repair of extensive bone defect after resection of lower limb malignant bone tumor.

EXPERIMENTAL STUDY OF AUTOGENOUS ILIAC GRAFTS ON CANINE

In this experiment, bone grafts with or without perios-teum were taken from both ilium, usually a small amont ofmuscle was attached. These two types of grafts were trans-ferred respectively to the subcutaneous layer of the feet andto the defects of the metacarpus. After the operation , thespeciments were under gross and histologic examinations, andvolumetric measurment of the grafts pericdically. Vascularregeneration was found one week after operation, and thosegrafts with periosteum showed vascular regeneration and less absoption more than those with no periosteum. The vascular regeneration of the abundant iliac grafts transfered to the dcfects was more than to the subcutaneous layer.