Objective To examine the feasibility and efficacy of narcotic drugs and the first Psychotropic drugs of Category handover procedures, which based on CA certification electronic signature technology in the anesthesia information management system. Methods The handover of narcotic drugs and the first class psychotropic drugs in 30 operating rooms of the Department of Anesthesiology at West China Tianfu Hospital of Sichuan University between June and July 2023 was selected as the research object. According to the handover of narcotic drugs and the first class psychotropic drugs, the 30 operating rooms that were handed over using paper-based system in June 2023 were designated as the traditional handover group, the 30 operating rooms that were handed over using CA certification electronic signature technology in July 2023 were designated as the paperless handover group. The time spent on quality control of management of narcotic and psychoactive drugs, the time spent on the handover of narcotic and psychiatric drugs, and the users’ effort degree and satisfaction by anesthesiologists and nurses were compared between the two groups. Results The traditional handover group completed 3027 surgeries, while the paperless handover group completed 3022 surgeries. There were no statistically significant difference in the daily average number of surgeries completed in the operating rooms [(137.59±10.81) vs.(137.36±11.98) cases] and usage of narcotics drugs and the first class psychotropic drugs [(713.91 ± 7.24) vs. (716.64 ± 6.53) pills] between the TPH and paperless handover groups. The time of checking drug handover records [(35.80±3.07) vs. (3.89±0.43）min] and the cost time of drugs handover [(6.07±0.55) vs. (3.57±0.39）min] in the traditional handover group were higher than those in the paperless handover group (P<0.001). The average laborious degres [(3.17±1.17) vs. (4.34±0.70)] and the satisfaction [(3.75±1.09) vs. (4.64±0.52)] of the traditional handover group are lower than those of the paperless handover group (P<0.001). Conclusions CA certification electronic signature technology significantly enhances management efficiency, reduces non-technical workload, optimizes the healthcare experience, and enables permanent storage and real-time retrieval of electronic records. It complies with data security and ecological healthcare requirements, making it highly worthy of application.