ObjectiveTo explore the association between the ZJU index and obstructive sleep apnea hypopnea syndrome (OSAHS) and to develop a prediction model based on ZJU index. MethodsClinical data of patients diagnosed by polysomnography were retrospectively collected from January 2021 to July 2024. Participants were categorized into OSAHS and non-OSAHS groups, and the general data of the two groups were compared. Regression analysis was performed to analyze the influencing factors of OSAHS, a prediction model of OSAHS was constructed based on the ZJU index, and the diagnostic efficacy was evaluated by using the subject's work characteristics (ROC) curve and calibration curve. Rusults A total of 211 patients were included in this study, including 165 in the OSAHS group and 46 in the non-OSAHS group. The multifactorial results showed that ZJU index and gender were the influencing factors for the occurrence of OSAHS (P<0.05), and a prediction model was constructed by combining the ZJU index with gender, and the area under the ROC curve (AUC) was 0.786 (95%CI: 0.717-0.85). The sensitivity was 51.5% and the specificity was 91.3%. The calibration curve showed good agreement between predicted and actual results. ConclusionZJU index is associated with OSAHS, and the prediction model constructed by ZJU index combined with gender could be well used to predict the occurrence of OSAHS.
Objective To understand the current situation of dietary organophosphate esters (OPEs) exposure, its effect on human health and its role in the occurrence and development of digestive system disease. Method We searched, analyzed and summarized the relevant literatures on the exposure of OPEs in diet and its effects on digestive system health. Results OPEs had long-term, extensive, and continuous exposure in diet. Although the exposure levels of different OPEs were different in time and space, its impact on digestive system health could not be ignored. OPEs might play a potential role in digestive system injury and tumorigenesis through the activation of inflammation related pathways and the expression change of cancer-related gene. Conclusions OPEs exposure may be a potential risk factor for digestive system injury and tumor. Further exploration of its pathogenic mechanism is of great significance to the screening of high risk factors, disease prevention, and health care.
