Objective We studied the change of psychological behavior and quality of life in children with epilepsy, to explore the treatment strategy to improve their psychological behavior and quality of life. Methods Collected forty children with epilepsy from Hebei General Hospital during March 2015 to October 2015 and 40 normal children in this study. "Epilepsy patients quality of life scale", "Daily life ability scale" and "Sense of uncertainty in hospitalized patients disease scale" test were performed to the participants. The difference of daily psychological behavior ability, sense of uncertainty in illness and quality of life between the two groups were analyzed. Results The epilepsy children’s daily life ability and the quality of life are lower than normal children (P<0.05), the disease uncertainty is higher than normal children (P<0.05). Conclusion The epilepsy children had serious psychological and behavior disorders and lower life quality. Some medical intervention should be taken to alleviate the psychological burden, improve the ability of daily life, reduce the uncertainty in illness, and comprehensively improve the quality of life of children with epilepsy.
In vitro hemolysis testing for blood pumps currently faces several challenges, including randomness in control group selection, and numerous sources of uncertainty in the testing methods. These issues lead to high uncertainty, insufficient result credibility, and limited comparability, which hinders the effective evaluation of blood damage induced by blood pumps. This study aims to address these limitations by developing a magnetically-levitated blood pump benchmark model and optimizing the hemolysis testing protocol to reduce result uncertainty. A magnetic bearing was utilized to minimize blood damage, and the injection molding was employed to enhance the machining precision of the pump. The experimental procedures, including blood collection, test loop setup, and the testing process, were optimized to effectively control experimental uncertainty. The results showed that the performance curve of the benchmark pump model was flat, and the coefficient of variation for the hydraulic experimental results was less than 5%. The secondary flow path exhibited good blood washout with no thrombus formation. Under low-flow condition, the average normalized index of hemolysis (NIH) was 0.014 g/100L, with a coefficient of variation of 19.50%. Under high-flow condition, the average NIH was 0.045 g/100L, with a coefficient of variation of 16.45%. The hemolysis values under both conditions were lower than the Abbott CentriMag. In conclusion, we designed a benchmark blood pump model with excellent hemocompatibility and optimized hemolysis testing protocol, which led to low uncertainty in experimental results. The benchmark and optimized hemolysis protocol help to improve the credibility and comparability of in vitro hemolysis testing data, providing a reliable solution for both the industry and regulatory agencies to assess hemocompatibility.
This is the fifth paper in the evidence-based medicine glossary series. In this paper, we mainly introduce the systematic error（bias）and random error in medical research, review the definition and classification of bias made by different institutions and individuals. We also identify and categorize more than 10 types of bias in systematic review, which are considered the best evidence in evidence-based medicine. Additionally, we introduce some methods to reduce and eliminate bias, explaine six subject headings related to bias in MeSH, and introduce a new glossary — uncertainty in metrology.