Therapeutic Effect of Transpupillary Thermotherapy on Circumscribed Choroidal Hemangioma_West China Medical Journal

Authors：

 WUQian-ying ,  LÜHong-bin

Department of Ophthalmology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, China;

Corresponding author：

LÜHong-bin, Email: oculistlvhongbin@163.com

Keywords：

Choroid neoplasms; Hemangioma/therapy; Transpupillary thermotherapy; Laser therapy; Therapeutic effect

DOI：

10.7507/1002-0179.20140453

Video：

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Objective To explore the therapeutic effect of transpupillary thermotherapy (TTT) on patient with circumscribed choroidal hemangioma (CCH). Methods The clinical data of 16 patients (16 eyes) with circumscribed choroidal hemangioma (CCH) from December 2011 to December 2012, which had been diagnosed by clinical general examination, fundus fluorescein angiography (FFA), and B-scanning ultrasound examination were retrospectively analyzed. The follow-up period was 6-24 months (mean 14 months). Results Among the 8 eyes with peripheral retinal detachment in 16 cases of CCH, the peripheral subretinal fluid was completely absorbed in 6 eyes, and partially absorbed in 2 eyes after TTT. The resultant visual acuity after treatment improved in 12 eyes, and maintained no change in 4 eyes. The results of B-scanning ultrasound examination showed that the thickness of tumor went down in 12 eyes obviously. The results of FFA revealed a significant decrease of the leakage in tumor in all of 16 cases and no complication was observed. Conclusion TTT is an effective therapy for CCH.

Citation： WUQian-ying, LÜHong-bin. Therapeutic Effect of Transpupillary Thermotherapy on Circumscribed Choroidal Hemangioma. West China Medical Journal, 2014, 29(8): 1476-1478. doi: 10.7507/1002-0179.20140453 Copy

1.	李凤鸣. 中华眼科学[M]. 2版. 北京:人民卫生出版社, 2005:2053-2054.
2.	张承芬, 董方因, 陈有信, 等.眼底病学[M]. 北京:人民卫生出版社, 1998:570.
3.	Zografos L, Bercher L, Chamot L, et al. Cobalt-60 treatment of choroidal hemangiomas[J]. Am J Ophthalmol, 1996, 121(2):190-199.
4.	Aizman A, Finger PT, Shabto U, et al. Palladium 103(103Pd) plaque radiation therapy for circumscribed choroidal hemangioma with retinal detachment[J]. Arch Ophthalmol, 2004, 122(11):1652-1656.
5.	Ritland JS, Eide N, Tausjo J. External beam irradiation therapy for choroidal haemangiomas. Visual and anatomical results after a dose of 20 to 25 Gy[J]. Acta Ophthalmologica Scandinavica, 2001, 79(2):184-186.
6.	Madreperla SA, Hungerford JL, Plowman PN, et al. Choroidal hemangiomas:visual and anatomic results of treatment by photocoagulation or radiation therapy[J]. Ophthalmology, 1997, 104(11):1773-1778.
7.	Hannouche D, Frau E, Desjardins L, et al. Efficacy of proton therapy in circumscribed choroidal hemangiomas associated with serious retinal detachment[J]. Ophthalmology, 1997, 104(11):1780-1784.
8.	吴又凯, 张清, 卜菊芬, 等. 氪红激光透热治疗视网膜下新生血管及脉络膜血管瘤的疗效分析[J]. 中国实用眼科杂志, 2003, 21(3):213-215.
9.	李春霞, 吉红云, 嵇金宝, 等. 孤立型脉络膜血管瘤的激光治疗[J]. 临床眼科杂志, 2005, 13(5):396-397.
10.	郭小健, 朱小华, 唐朝珍, 等. 孤立型脉络膜血管瘤的氩激光治疗观察[J]. 实用预防医学, 2004, 11(1):60-62.
11.	彭晓燕, 王光璐. 经瞳孔温热疗法治疗孤立性脉络膜血管瘤[J]. 中华眼底病杂志, 2002, 18(3):25-27.
12.	Madreperla SA. Choroidal hemangioma treated with photodynamic therapy using verteporfin[J]. Arch Ophthalmol, 2001, 119(11):1606-1610.
13.	Anand R, Augsburger JJ, Shields JA. Circumscribed choroidal hemangiomas[J]. Arch Ophthalmol, 1989, 107(9):1338-1342.
14.	Landau IM, Steen B, Seregard S. Photodynamic therapy for circumscribed choroidal haemangioma[J]. Acta Ophthalmologica Scandinavica, 2002, 80(5):531-536.
15.	Jurklies B, Anastassiou G, Ortmans S, et al. Photodynamic therapy using verteporfin in circumscribed choroidal haemangioma[J]. Br J Ophthalmol, 2003, 87(1):84-89.
16.	Shields JA, Shields CL, Materin MA, et al. Changing concepts in management of circumscribed choroidal hemangioma:the 2003 J. Howard Stokes Lecture, Part 1[J]. Ophthalmic Surg, Lasers Imaging, 2004, 35(5):383-394.
17.	Gupta M, Singh AD, Rundle PA, et al. Efficacy of photodynamic therapy in circumscribed choroidal haemangioma[J]. Eye (London, England), 2004, 18(2):139-142.
18.	Singh AD, Kaiser PK, Sears JE, et al. Photodynamic therapy of circumscribed choroidal haemangioma[J]. Br J Ophthalmol, 2004, 88(11):1414-1418.
19.	Michels S, Michels R, Simader C, et al. Verteporfin therapy for choroidal hemangioma:a long-term follow-up[J]. Retina (Phila, Pa), 2005, 25(6):697-703.
20.	Vicuna-Kojchen J, Banin E, Averbukh E, et al. Application of the standard photodynamic treatment protocol for symptomatic circumscribed choroidal hemangioma[J]. Ophthalmologica, 2006, 220(6):351-355.
21.	Desmettre T, Maurage CA, Mordon S. Heat shock protein hyperexpression on chorioretinal layers after transpupillary thermotherapy[J]. Invest Ophthalmol Vis Sci, 2001, 42(12):2976-2980.
22.	张承芬, 董方田, 陈有信, 等. 经瞳孔温热疗法治疗限局性脉络膜血管瘤[J]. 中华眼科杂志, 2005, 41(10):23-27.
23.	陈蕾, 万超. 经瞳孔温热疗法治疗局限性脉络膜血管瘤的疗效观察[J]. 中国激光医学杂志, 2005, 14(5):295-299.
24.	Garcia-Arumi J, Ramsay LS, Guraya BC. Transpupillary thermotherapy for circumscribed choroidal hemangiomas[J]. Ophthalmology, 2000, 107(2):351-356.
25.	Gunduz K. Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma[J]. Surv Ophthalmol, 2004, 49(3):316-327.

1. 李凤鸣. 中华眼科学[M]. 2版. 北京:人民卫生出版社, 2005:2053-2054.
2. 张承芬, 董方因, 陈有信, 等.眼底病学[M]. 北京:人民卫生出版社, 1998:570.
3. Zografos L, Bercher L, Chamot L, et al. Cobalt-60 treatment of choroidal hemangiomas[J]. Am J Ophthalmol, 1996, 121(2):190-199.
4. Aizman A, Finger PT, Shabto U, et al. Palladium 103(103Pd) plaque radiation therapy for circumscribed choroidal hemangioma with retinal detachment[J]. Arch Ophthalmol, 2004, 122(11):1652-1656.
5. Ritland JS, Eide N, Tausjo J. External beam irradiation therapy for choroidal haemangiomas. Visual and anatomical results after a dose of 20 to 25 Gy[J]. Acta Ophthalmologica Scandinavica, 2001, 79(2):184-186.
6. Madreperla SA, Hungerford JL, Plowman PN, et al. Choroidal hemangiomas:visual and anatomic results of treatment by photocoagulation or radiation therapy[J]. Ophthalmology, 1997, 104(11):1773-1778.
7. Hannouche D, Frau E, Desjardins L, et al. Efficacy of proton therapy in circumscribed choroidal hemangiomas associated with serious retinal detachment[J]. Ophthalmology, 1997, 104(11):1780-1784.
8. 吴又凯, 张清, 卜菊芬, 等. 氪红激光透热治疗视网膜下新生血管及脉络膜血管瘤的疗效分析[J]. 中国实用眼科杂志, 2003, 21(3):213-215.
9. 李春霞, 吉红云, 嵇金宝, 等. 孤立型脉络膜血管瘤的激光治疗[J]. 临床眼科杂志, 2005, 13(5):396-397.
10. 郭小健, 朱小华, 唐朝珍, 等. 孤立型脉络膜血管瘤的氩激光治疗观察[J]. 实用预防医学, 2004, 11(1):60-62.
11. 彭晓燕, 王光璐. 经瞳孔温热疗法治疗孤立性脉络膜血管瘤[J]. 中华眼底病杂志, 2002, 18(3):25-27.
12. Madreperla SA. Choroidal hemangioma treated with photodynamic therapy using verteporfin[J]. Arch Ophthalmol, 2001, 119(11):1606-1610.
13. Anand R, Augsburger JJ, Shields JA. Circumscribed choroidal hemangiomas[J]. Arch Ophthalmol, 1989, 107(9):1338-1342.
14. Landau IM, Steen B, Seregard S. Photodynamic therapy for circumscribed choroidal haemangioma[J]. Acta Ophthalmologica Scandinavica, 2002, 80(5):531-536.
15. Jurklies B, Anastassiou G, Ortmans S, et al. Photodynamic therapy using verteporfin in circumscribed choroidal haemangioma[J]. Br J Ophthalmol, 2003, 87(1):84-89.
16. Shields JA, Shields CL, Materin MA, et al. Changing concepts in management of circumscribed choroidal hemangioma:the 2003 J. Howard Stokes Lecture, Part 1[J]. Ophthalmic Surg, Lasers Imaging, 2004, 35(5):383-394.
17. Gupta M, Singh AD, Rundle PA, et al. Efficacy of photodynamic therapy in circumscribed choroidal haemangioma[J]. Eye (London, England), 2004, 18(2):139-142.
18. Singh AD, Kaiser PK, Sears JE, et al. Photodynamic therapy of circumscribed choroidal haemangioma[J]. Br J Ophthalmol, 2004, 88(11):1414-1418.
19. Michels S, Michels R, Simader C, et al. Verteporfin therapy for choroidal hemangioma:a long-term follow-up[J]. Retina (Phila, Pa), 2005, 25(6):697-703.
20. Vicuna-Kojchen J, Banin E, Averbukh E, et al. Application of the standard photodynamic treatment protocol for symptomatic circumscribed choroidal hemangioma[J]. Ophthalmologica, 2006, 220(6):351-355.
21. Desmettre T, Maurage CA, Mordon S. Heat shock protein hyperexpression on chorioretinal layers after transpupillary thermotherapy[J]. Invest Ophthalmol Vis Sci, 2001, 42(12):2976-2980.
22. 张承芬, 董方田, 陈有信, 等. 经瞳孔温热疗法治疗限局性脉络膜血管瘤[J]. 中华眼科杂志, 2005, 41(10):23-27.
23. 陈蕾, 万超. 经瞳孔温热疗法治疗局限性脉络膜血管瘤的疗效观察[J]. 中国激光医学杂志, 2005, 14(5):295-299.
24. Garcia-Arumi J, Ramsay LS, Guraya BC. Transpupillary thermotherapy for circumscribed choroidal hemangiomas[J]. Ophthalmology, 2000, 107(2):351-356.
25. Gunduz K. Transpupillary thermotherapy in the management of circumscribed choroidal hemangioma[J]. Surv Ophthalmol, 2004, 49(3):316-327.

West China Medical Journal

Therapeutic Effect of Transpupillary Thermotherapy on Circumscribed Choroidal Hemangioma

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