Clinical Feature Analysis of Obstructive Sleep Apnea-hypopnea Syndrome with Pulmonary Embolism_West China Medical Journal

Authors：

 ZHOUZhong-wei , ZOUJun

Department of Respiratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

Keywords：

Obstructive sleep apnea-hyponea syndrome; Pulmonary thromboembolism; Severity of disease; Treatment

DOI：

10.7507/1002-0179.20140548

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Objective To observe the impact of obstructive sleep apnea-hyponea syndrome (OSAHS) on the severity of pulmonary thromboembolism (PTE) and its treatment strategies. Methods PTE patients hospitalized in our department between January 2006 and December 2012 were screened for this study, including 16 patients with OSAHS and 20 patients without OSAHS, and the difference in clinical characteristics such as arterial blood gas, apnea-hypopnea index, lowest pulse oxygen saturation (LSpO₂) and treatment methods were analyzed and compared between the two groups. Results As compared to PTE patients without OSAHS, the age of patients was lower[(53.4±12.1), (64.5±9.8) years; P=0.005], while body mass index[(29.3±2.2), (26.1±3.3) kg/m², P=0.002] and smoking index (150±24, 101±18; P<0.001) were higher in PTE patients with OSAHS. Additionally, significantly lower LSpO₂[(71.7±8.3), (79.4±7.1) mm Hg (1 mm Hg=0.133 kPa); P=0.005] and more lung segments (8±3, 5±2; P=0.001) were involved in PTE patients with OSAHS. In this cohort, all patients received anticoagulation and/or thrombolysis treatment, but the rate of continuous positive airway pressure (CPAP) ventilation application was significantly higher in PTE patients with OSAHS. Conclusion PTE patients with OSAHS have relatively lower age but serious condition, and both anticoagulation and CPAP should be used in the clinical treatment.

Citation： ZHOUZhong-wei, ZOUJun. Clinical Feature Analysis of Obstructive Sleep Apnea-hypopnea Syndrome with Pulmonary Embolism. West China Medical Journal, 2014, 29(10): 1801-1804. doi: 10.7507/1002-0179.20140548 Copy

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12.	冼乐武, 李涛平, 梁宗安, 等. 阻塞性睡眠呼吸暂停低通气综合征患者晚期氧化蛋白产物测定的临床意义[J]. 中国呼吸与危重监护杂志, 2011,10(3):220-223.
13.	Epstein MD, Segal LN, Ibrahim SM, et al. Snoring and the risk of obstructive sleep apnea in patients with pulmonary embolism[J]. Sleep, 2010, 33(8):1069-1074.
14.	张立强. 阻塞性睡眠呼吸暂停低通气综合征与肺血栓栓塞症的关系[J]. 中华临床医师杂志·电子版, 2013, 7(21):9-10.
15.	陈宇洁, 赵杰, 万小兵, 等. 阻塞性睡眠呼吸暂停低通气综合征患者病情程度与临床特征关系探讨[J]. 华西医学, 2007, 22(3):609.
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1. 洪昭光, 张维君, 房芳. 肺栓塞的流行病学[J]. 中华心血管病杂志, 2001, 29(5):7-8.
2. 徐巧莲, 万献尧. 急性肺栓塞的诊断和治疗[J]. 中国呼吸与危重监护杂志, 2011, 10(3):308-312.
3. 谢仕津, 梁灼萍. 阻塞性睡眠呼吸暂停低通气综合征的病因与诊治研究现状[J]. 西南军医, 2011, 13(3):505-508.
4. 王毓洲, 黄席珍. 阻塞性睡眠呼吸暂停/低通气综合征的发病机理[J]. 中国全科医学, 2002, 5(3):178-179.
5. 马国强, 代国仪, 王佳烈. 阻塞性睡眠呼吸暂停低通气综合征的研究进展[J]. 中国医药导报, 2007, 4(31):25-28.
6. 樊利萍, 王蓓, 刘卓拉. 阻塞性睡眠呼吸暂停低通气综合征与高血压的关系[J]. 临床医药实践杂志, 2008, 17(6):429-431.
7. 张向峰, 丁少芳, 朱光发, 等. 24例合并肺血栓栓塞症的阻塞性睡眠呼吸暂停低通气综合征患者临床特点及治疗分析[J]. 中国呼吸与危重监护杂志, 2011, 10(6):568-571.
8. 吴培英. 肺血栓栓塞症26例临床分析[J]. 实用心脑肺血管病杂志, 2008, 16(10):47-48.
9. 刘北林, 黎静. 肺血栓栓塞症25例临床分析[J]. 华西医学, 2009, 24(10):2617-2618.
10. 孙葵葵, 王辰, 古力夏提, 等. 深静脉血栓形成的危险因素及临床分析[J]. 中华结核和呼吸杂志, 2004, 27(11):727-730.
11. 梁民勇, 张田, 何忠. 阻塞性睡眠呼吸暂停低通气综合征合并慢性阻塞性肺疾病的治疗进展[J]. 中国社区医师·医学专业, 2012, 14(36):151, 153.
12. 冼乐武, 李涛平, 梁宗安, 等. 阻塞性睡眠呼吸暂停低通气综合征患者晚期氧化蛋白产物测定的临床意义[J]. 中国呼吸与危重监护杂志, 2011,10(3):220-223.
13. Epstein MD, Segal LN, Ibrahim SM, et al. Snoring and the risk of obstructive sleep apnea in patients with pulmonary embolism[J]. Sleep, 2010, 33(8):1069-1074.
14. 张立强. 阻塞性睡眠呼吸暂停低通气综合征与肺血栓栓塞症的关系[J]. 中华临床医师杂志·电子版, 2013, 7(21):9-10.
15. 陈宇洁, 赵杰, 万小兵, 等. 阻塞性睡眠呼吸暂停低通气综合征患者病情程度与临床特征关系探讨[J]. 华西医学, 2007, 22(3):609.
16. 刘辉国, 徐永健. 慢性阻塞性肺疾病睡眠低氧现状与诊治进展[J]. 中国实用内科杂志, 2010, 30(4):300-303.

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Clinical Feature Analysis of Obstructive Sleep Apnea-hypopnea Syndrome with Pulmonary Embolism

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