Analysis of the occurrence and influencing factors of fatigue in asthma patients_West China Medical Journal

Authors：

QIN Fujia ¹ ,  CUI Miaoling ² , NONG ying ³

1. Graduate School of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China;
2. Department of Nursing, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China;
3. Department of Respiratory Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China;

Corresponding author：

CUI Miaoling, Email: cuimiaoling@126.com

Keywords：

Bronchial asthma; Fatigue; Influencing factors; Depression

DOI：

10.7507/1002-0179.201909024

Video：

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Objective To investigate the fatigue of asthma patients, and to analyze its influencing factors, and provide a reference for clinical intervention.Methods The convenience sampling method was adopted to select asthma patients who were in clinic of the First Affiliated Hospital of Guangxi Medical University from November 2018 to March 2019. The patients’ lung function were measured. And questionnaires were conducted, including general data questionnaire, Chinese version of Checklist Individual Strength-Fatigue, Asthma Control Test, Chinese version of Self-rating Depression Scale. Relevant data were collected for multiple stepwise linear regression analysis.Results Finally, 120 patients were enrolled. The results of multiple stepwise linear regression analysis showed that age, education level, place of residence, time period of frequent asthma symptoms, degree of small airway obstruction, Asthma Control Test score and degree of depression were the influencing factors of fatigue in asthma patients (P≤0.05). Multivariate linear stepwise regression analysis showed that degree of small airway obstruction, degree of depression and time period of frequent asthma symptoms were the main influencing factors of fatigue in asthma patients, which could explain 51.8% of the variance of fatigue (ΔR²=0.518).Conclusions The incidence of fatigue in asthma patients is at a relatively high level. Medical staff should pay attention to the symptoms of fatigue in asthma patients. For asthma patients, it is recommended to strengthen standardized diagnosis and treatment, reduce the onset of symptoms at night and eliminate small airway obstruction. Psychological intervention methods are needed to improve patients’ depression, reduce fatigue symptoms, and improve quality of life.

Citation： QIN Fujia, CUI Miaoling, NONG ying. Analysis of the occurrence and influencing factors of fatigue in asthma patients. West China Medical Journal, 2021, 36(1): 45-49. doi: 10.7507/1002-0179.201909024 Copy

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2.	Van Herck M, Spruit MA, Burtin C, et al. Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease. J Clin Med, 2018, 7(12): 471.
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11.	王天芳, 张翠珍, 刘雁峰. 慢性疲劳综合征病人的疲劳、抑郁、焦虑与生活事件的特点及其相关性分析. 中国行为医学科学, 2000, 9(2): 84.
12.	Peters JB, Rijssenbeek-Nouwens LH, Bron AO, et al. Health status measurement in patients with severe asthma. Respir Med, 2014, 108(2): 278-286.
13.	王文雅. 2010-2011 年北京地区 14 岁以上人群哮喘患病情况及相关危险因素的流行病学调查. 北京: 北京协和医学院, 2013:1-100.
14.	徐艺园, 王凯, 王佳音, 等. 疲劳产生相关机制研究进展. 科学技术创新, 2019(23): 50-51.
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18.	房莉颖, 李圣青, 吴林. 支气管哮喘与抑郁相关性研究. 陕西医学杂志, 2016, 45(9): 1120-1122.
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1. 张晓岩, 林江涛. 2017 年全球哮喘防治倡议指南解读. 中国实用内科杂志, 2017, 37(8): 709-711.
2. Van Herck M, Spruit MA, Burtin C, et al. Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease. J Clin Med, 2018, 7(12): 471.
3. Small S, Lamb M. Fatigue in chronic illness: the experience of individuals with chronic obstructive pulmonary disease and with asthma. J Adv Nurs, 1999, 30(2): 469-478.
4. 倪平, 陈京立, 刘娜. 护理研究中量性研究的样本量估计. 中华护理杂志, 2010, 45(4): 378-380.
5. 中华医学会儿科学分会呼吸学组肺功能协作组, 《中华实用儿科临床杂志》编辑委员会. 儿童肺功能系列指南(二): 肺容积和通气功能. 中华实用儿科临床杂志, 2016, 31(10): 744-750.
6. 罗国标, 张灵娟, 刘国清, 等. 肺功能中不同气道功能指标联合筛查用于慢性阻塞性肺疾病早期诊断价值及预后判断研究. 心肺血管病杂志, 2019, 38(4): 377-381.
7. Vercoulen JH, Swanink CM, Fennis JF, et al. Dimensional assessment of chronic fatigue syndrome. J Psychosom Res, 1994, 38(5): 383-392.
8. 吴春薇, 刘占东, 张拥波, 等. 个人疲劳强度问卷中译本在脑梗死患者中的临床应用与评价. 中国康复理论与实践, 2008, 14(2): 116-118.
9. Schatz M, Sorkness CA, Li JT, et al. Asthma control test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists. J Allergy Clin Immunol, 2006, 117(3): 549-556.
10. 段泉泉, 胜利. 焦虑及抑郁自评量表的临床效度. 中国心理卫生杂志, 2012, 26(9): 676-679.
11. 王天芳, 张翠珍, 刘雁峰. 慢性疲劳综合征病人的疲劳、抑郁、焦虑与生活事件的特点及其相关性分析. 中国行为医学科学, 2000, 9(2): 84.
12. Peters JB, Rijssenbeek-Nouwens LH, Bron AO, et al. Health status measurement in patients with severe asthma. Respir Med, 2014, 108(2): 278-286.
13. 王文雅. 2010-2011 年北京地区 14 岁以上人群哮喘患病情况及相关危险因素的流行病学调查. 北京: 北京协和医学院, 2013:1-100.
14. 徐艺园, 王凯, 王佳音, 等. 疲劳产生相关机制研究进展. 科学技术创新, 2019(23): 50-51.
15. Demyttenaere K, De Fruyt J, Stahl SM. The many faces of fatigue in major depressive disorder. Int J Neuropsychopharmacol, 2005, 8(1): 93-105.
16. Michel P, Bogousslavsky J. Shared mechanisms of ischaemic and haemorrhagic stroke: still a lot to learn. J Neurol Neurosurg Psychiatry, 2006, 77(1): 1.
17. Bossola M, Di Stasio E, Giungi S, et al. Fatigue is associated with serum interleukin-6 levels and symptoms of depression in patients on chronic hemodialysis. J Pain Symptom Manage, 2015, 49(3): 578-585.
18. 房莉颖, 李圣青, 吴林. 支气管哮喘与抑郁相关性研究. 陕西医学杂志, 2016, 45(9): 1120-1122.
19. Yohannes AM, Baldwin RC, Connolly MJ. Depression and anxiety in elderly patients with chronic obstructive pulmonary disease. Age Ageing, 2006, 35(5): 457-459.

West China Medical Journal

Analysis of the occurrence and influencing factors of fatigue in asthma patients

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