Clinical research progress of sarcopenia and frailty in maintenance hemodialysis patients_West China Medical Journal

Authors：

HE Maoxin ¹ ,  YUAN Huaihong ¹ , YANG Yujie ¹ , YU Shaobin ² , FU Ping ²

1. Department of Nephrology, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Nephrology / Kidney Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YUAN Huaihong, Email: yuanhuaihong@wchscu.cn

Keywords：

Maintenance hemodialysis; sarcopenia; frailty

DOI：

10.7507/1002-0179.202202025

Video：

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Abstract Full text Figures/Tables Video References Cited by

The incidence of sarcopenia and frailty in maintenance hemodialysis patients are high, and there are often comorbidities, which easily lead to more complications, thus increasing the hospitalization rate and reducing the quality of life of patients. This article reviews the definition, physiological mechanism, incidence and diagnosis, relationship and treatment strategies of sarcopenia and frailty in maintenance hemodialysis patients, in order to better prevent and intervene the occurrence of sarcopenia and frailty and provide a reference for prevention and treatment.

Citation： HE Maoxin, YUAN Huaihong, YANG Yujie, YU Shaobin, FU Ping. Clinical research progress of sarcopenia and frailty in maintenance hemodialysis patients. West China Medical Journal, 2022, 37(11): 1720-1725. doi: 10.7507/1002-0179.202202025 Copy

1.	吴芳, 王福诩, 周红卫. 维持性血液透析患者蛋白质能量消耗临床研究进展. 中国血液净化, 2019, 18(2): 127-130.
2.	Garcia-Canton C, Rodenas A, Lopez-Aperador C, et al. Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services. Ren Fail, 2019, 41(1): 567-575.
3.	Yoneki K, Kitagawa J, Hoshi K, et al. Association between frailty and bone loss in patients undergoing maintenance hemodialysis. J Bone Miner Metab, 2019, 37(1): 81-89.
4.	Yadla M, John JP, Mummadi M. A study of clinical assessment of frailty in patients on maintenance hemodialysis supported by cashless government scheme. Saudi J Kidney Dis Transpl, 2017, 28(1): 15-22.
5.	López-Montes A, Martínez-Villaescusa M, Pérez-Rodríguez A, et al. Frailty, physical function and affective status in elderly patients on hemodialysis. Arch Gerontol Geriatr, 2020, 87: 103976.
6.	杜兰玉, 胡霞, 王向弘, 等. 380 例维持性血液透析患者衰弱现状及其对预后的影响. 护理学报, 2018, 25(20): 37-41.
7.	陈管洁, 张海林, 尹丽霞, 等. 维持性血液透析患者认知功能障碍与衰弱的相关性. 护理学杂志, 2021, 36(6): 27-31.
8.	Ren H, Gong D, Jia F, et al. Sarcopenia in patients undergoing maintenance hemodialysis: incidence rate, risk factors and its effect on survival risk. Ren Fail, 2016, 38(3): 364-371.
9.	Lamarca F, Carrero JJ, Rodrigues JC, et al. Prevalence of sarcopenia in elderly maintenance hemodialysis patients: the impact of different diagnostic criteria. J Nutr Health Aging, 2014, 18(7): 710-717.
10.	董志娟, 张海林. 维持性血液透析患者肌少症发生的危险因素分析. 护理学杂志, 2018, 33(9): 20-24.
11.	李兰, 温贤秀, 夏琪, 等. 维持性血液透析患者肌少症患病率的 meta 分析. 现代预防医学, 2021, 48(22): 4214-4218.
12.	江山秀. 维持性血液透析患者衰弱风险预测模型的构建. 湖州: 湖州师范学院, 2022.
13.	Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
14.	Yoowannakul S, Tangvoraphonkchai K, Vongsanim S, et al. Differences in the prevalence of sarcopenia in haemodialysis patients: the effects of gender and ethnicity. J Hum Nutr Diet, 2018, 31(5): 689-696.
15.	Giglio J, Kamimura MA, Lamarca F, et al. Association of sarcopenia with nutritional parameters, quality of life, hospitalization, and mortality rates of elderly patients on hemodialysis. J Ren Nutr, 2018, 28(3): 197-207.
16.	Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet, 2013, 381(9868): 752-762.
17.	Kutner NG, Zhang R, Allman RM, et al. Correlates of ADL difficulty in a large hemodialysis cohort. Hemodial Int, 2014, 18(1): 70-77.
18.	Bao Y, Dalrymple L, Chertow GM, et al. Frailty, dialysis initiation, and mortality in end-stage renal disease. Arch Intern Med, 2012, 172(14): 1071-1077.
19.	García-Prat L, Martínez-Vicente M, Perdiguero E, et al. Autophagy maintains stemness by preventing senescence. Nature, 2016, 529(7584): 37-42.
20.	Noce A, Bocedi A, Campo M, et al. A pilot study of a natural food supplement as new possible therapeutic approach in chronic kidney disease patients. Pharmaceuticals (Basel), 2020, 13(7): 148.
21.	Romani A, Bernini R, Noce A, et al. Potential beneficial effects of extra virgin olive oils characterized by high content in minor polar compounds in nephropathic patients: a pilot study. Molecules, 2020, 25(20): 4757.
22.	Honda H, Qureshi AR, Axelsson J, et al. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr, 2007, 86(3): 633-638.
23.	Raj DS, Sun Y, Tzamaloukas AH. Hypercatabolism in dialysis patients. Curr Opin Nephrol Hypertens, 2008, 17(6): 589-594.
24.	Sun DF, Chen Y, Rabkin R. Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. Kidney Int, 2006, 70(3): 453-459.
25.	Deleaval P, Luaire B, Laffay P, et al. Short-term effects of branched-chain amino acids-enriched dialysis fluid on branched-chain amino acids plasma level and mass balance: a randomized cross-over study. J Ren Nutr, 2020, 30(1): 61-68.
26.	Mitch WE, Price SR. Mechanisms activated by kidney disease and the loss of muscle mass. Am J Kidney Dis, 2001, 38(6): 1337-1342.
27.	Kalantar-Zadeh K, Kopple JD, Deepak S, et al. Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire. J Ren Nutr, 2002, 12(1): 17-31.
28.	Roshanravan B, Gamboa J, Wilund K. Exercise and CKD: skeletal muscle dysfunction and practical application of exercise to prevent and treat physical impairments in CKD. Am J Kidney Dis, 2017, 69(6): 837-852.
29.	Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-M156.
30.	GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733.
31.	Carney EF. The impact of chronic kidney disease on global health. Nat Rev Nephrol, 2020, 16(5): 251.
32.	朱亚杰. 老年维持性血液透析患者衰弱相关因素及规律脚踏车运动的干预效果评价. 延安: 延安大学, 2022.
33.	Lee SW, Lee A, Yu MY, et al. Is frailty a modifiable risk factor of future adverse outcomes in elderly patients with incident end-stage renal disease?. J Korean Med Sci, 2017, 32(11): 1800-1806.
34.	Lee HJ, Son YJ. Prevalence and associated factors of frailty and mortality in patients with end-stage renal disease undergoing hemodialysis: a systematic review and meta-analysis. Int J Environ Res Public Health, 2021, 18(7): 3471.
35.	吴淑琳, 宋洁, 肖萍, 等. 维持性血液透析患者衰弱发生率及影响因素的系统评价. 中华护理教育, 2021, 18(4): 352-357.
36.	Nitta K, Hanafusa N, Tsuchiya K. Role of frailty on outcomes of dialysis patients. Contrib Nephrol, 2018, 195: 102-109.
37.	Nitta K, Tsuchiya K. Recent advances in the pathophysiology and management of protein-energy wasting in chronic kidney disease. Ren Replace Ther, 2016, 2(1): 1-12.
38.	蔡康琴, 李伟, 王莉, 等. 血液透析患者衰弱现状的调查研究. 护理学杂志, 2019, 34(11): 24-27.
39.	叶丽钦, 周莹, 张海林, 等. 维持性血液透析患者衰弱及其表型对生活质量的影响研究. 中华护理杂志, 2018, 53(9): 1072-1077.
40.	Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 2020, 21(3): 300-307.e2.
41.	Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 2014, 15(2): 95-101.
42.	韩君, 王君俏, 谢博钦, 等. Fried 衰弱表型和 FRAIL 量表及埃德蒙顿衰弱评估量表在社区高龄老年人衰弱筛查中一致性和适用性的比较研究. 中国全科医学, 2021, 24(21): 2669-2675.
43.	Ensrud KE, Ewing SK, Cawthon PM, et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc, 2009, 57(3): 492-498.
44.	Metsemakers WJ, Morgenstern M, McNally MA, et al. Fracture-related infection: a consensus on definition from an international expert group. Injury, 2018, 49(3): 505-510.
45.	武力, 郑燕蓉, 柴源. 老年住院患者衰弱程度与肌肉减少症严重程度的相关性分析. 现代医学, 2020, 48(5): 647-651.
46.	Delgado C, Doyle JW, Johansen KL. Association of frailty with body composition among patients on hemodialysis. J Ren Nutr, 2013, 23(5): 356-362.
47.	宋良晨, 蔡晓燕, 敖强国, 等. 衰弱对老年男性慢性肾脏病患者发生肌少症的影响. 中华老年心脑血管病杂志, 2020, 22(3): 249-252.
48.	Gielen E, Beckwée D, Delaere A, et al. Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses. Nutr Rev, 2021, 79(2): 121-147.
49.	翟婉春, 吴树敏, 黄海群. 运动训练对改善维持性血液透析患者衰弱症的研究进展. 中国保健营养, 2021, 31(9): 8-9.
50.	董欣, 莫懿晗, 王秀华, 等. 抗阻运动对老年肌少症危险人群肌肉量、肌力和活动能力的影响. 中国护理管理, 2021, 21(8): 1190-1195.
51.	Kirkman DL, Mullins P, Junglee NA, et al. Anabolic exercise in haemodialysis patients: a randomised controlled pilot study. J Cachexia Sarcopenia Muscle, 2014, 5(3): 199-207.
52.	Abdala R, Elena Del Valle E, Negri AL, et al. Sarcopenia in hemodialysis patients from Buenos Aires, Argentina. Osteoporos Sarcopenia, 2021, 7(2): 75-80.
53.	孙超, 侯莉明, 简伟明, 等. 我国 60 岁以上老年人群肌少症患病率及相关因素调查. 中华老年医学杂志, 2021, 40(8): 981-986.
54.	Stockton KA, Mengersen K, Paratz JD, et al. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int, 2011, 22(3): 859-871.
55.	Lin YL, Chen SY, Lai YH, et al. Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients. BMC Nephrol, 2019, 20(1): 54.
56.	Rolland Y, Onder G, Morley JE, et al. Current and future pharmacologic treatment of sarcopenia. Clin Geriatr Med, 2011, 27(3): 423-447.

1. 吴芳, 王福诩, 周红卫. 维持性血液透析患者蛋白质能量消耗临床研究进展. 中国血液净化, 2019, 18(2): 127-130.
2. Garcia-Canton C, Rodenas A, Lopez-Aperador C, et al. Frailty in hemodialysis and prediction of poor short-term outcome: mortality, hospitalization and visits to hospital emergency services. Ren Fail, 2019, 41(1): 567-575.
3. Yoneki K, Kitagawa J, Hoshi K, et al. Association between frailty and bone loss in patients undergoing maintenance hemodialysis. J Bone Miner Metab, 2019, 37(1): 81-89.
4. Yadla M, John JP, Mummadi M. A study of clinical assessment of frailty in patients on maintenance hemodialysis supported by cashless government scheme. Saudi J Kidney Dis Transpl, 2017, 28(1): 15-22.
5. López-Montes A, Martínez-Villaescusa M, Pérez-Rodríguez A, et al. Frailty, physical function and affective status in elderly patients on hemodialysis. Arch Gerontol Geriatr, 2020, 87: 103976.
6. 杜兰玉, 胡霞, 王向弘, 等. 380 例维持性血液透析患者衰弱现状及其对预后的影响. 护理学报, 2018, 25(20): 37-41.
7. 陈管洁, 张海林, 尹丽霞, 等. 维持性血液透析患者认知功能障碍与衰弱的相关性. 护理学杂志, 2021, 36(6): 27-31.
8. Ren H, Gong D, Jia F, et al. Sarcopenia in patients undergoing maintenance hemodialysis: incidence rate, risk factors and its effect on survival risk. Ren Fail, 2016, 38(3): 364-371.
9. Lamarca F, Carrero JJ, Rodrigues JC, et al. Prevalence of sarcopenia in elderly maintenance hemodialysis patients: the impact of different diagnostic criteria. J Nutr Health Aging, 2014, 18(7): 710-717.
10. 董志娟, 张海林. 维持性血液透析患者肌少症发生的危险因素分析. 护理学杂志, 2018, 33(9): 20-24.
11. 李兰, 温贤秀, 夏琪, 等. 维持性血液透析患者肌少症患病率的 meta 分析. 现代预防医学, 2021, 48(22): 4214-4218.
12. 江山秀. 维持性血液透析患者衰弱风险预测模型的构建. 湖州: 湖州师范学院, 2022.
13. Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 2019, 48(1): 16-31.
14. Yoowannakul S, Tangvoraphonkchai K, Vongsanim S, et al. Differences in the prevalence of sarcopenia in haemodialysis patients: the effects of gender and ethnicity. J Hum Nutr Diet, 2018, 31(5): 689-696.
15. Giglio J, Kamimura MA, Lamarca F, et al. Association of sarcopenia with nutritional parameters, quality of life, hospitalization, and mortality rates of elderly patients on hemodialysis. J Ren Nutr, 2018, 28(3): 197-207.
16. Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet, 2013, 381(9868): 752-762.
17. Kutner NG, Zhang R, Allman RM, et al. Correlates of ADL difficulty in a large hemodialysis cohort. Hemodial Int, 2014, 18(1): 70-77.
18. Bao Y, Dalrymple L, Chertow GM, et al. Frailty, dialysis initiation, and mortality in end-stage renal disease. Arch Intern Med, 2012, 172(14): 1071-1077.
19. García-Prat L, Martínez-Vicente M, Perdiguero E, et al. Autophagy maintains stemness by preventing senescence. Nature, 2016, 529(7584): 37-42.
20. Noce A, Bocedi A, Campo M, et al. A pilot study of a natural food supplement as new possible therapeutic approach in chronic kidney disease patients. Pharmaceuticals (Basel), 2020, 13(7): 148.
21. Romani A, Bernini R, Noce A, et al. Potential beneficial effects of extra virgin olive oils characterized by high content in minor polar compounds in nephropathic patients: a pilot study. Molecules, 2020, 25(20): 4757.
22. Honda H, Qureshi AR, Axelsson J, et al. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr, 2007, 86(3): 633-638.
23. Raj DS, Sun Y, Tzamaloukas AH. Hypercatabolism in dialysis patients. Curr Opin Nephrol Hypertens, 2008, 17(6): 589-594.
24. Sun DF, Chen Y, Rabkin R. Work-induced changes in skeletal muscle IGF-1 and myostatin gene expression in uremia. Kidney Int, 2006, 70(3): 453-459.
25. Deleaval P, Luaire B, Laffay P, et al. Short-term effects of branched-chain amino acids-enriched dialysis fluid on branched-chain amino acids plasma level and mass balance: a randomized cross-over study. J Ren Nutr, 2020, 30(1): 61-68.
26. Mitch WE, Price SR. Mechanisms activated by kidney disease and the loss of muscle mass. Am J Kidney Dis, 2001, 38(6): 1337-1342.
27. Kalantar-Zadeh K, Kopple JD, Deepak S, et al. Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire. J Ren Nutr, 2002, 12(1): 17-31.
28. Roshanravan B, Gamboa J, Wilund K. Exercise and CKD: skeletal muscle dysfunction and practical application of exercise to prevent and treat physical impairments in CKD. Am J Kidney Dis, 2017, 69(6): 837-852.
29. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 2001, 56(3): M146-M156.
30. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 2020, 395(10225): 709-733.
31. Carney EF. The impact of chronic kidney disease on global health. Nat Rev Nephrol, 2020, 16(5): 251.
32. 朱亚杰. 老年维持性血液透析患者衰弱相关因素及规律脚踏车运动的干预效果评价. 延安: 延安大学, 2022.
33. Lee SW, Lee A, Yu MY, et al. Is frailty a modifiable risk factor of future adverse outcomes in elderly patients with incident end-stage renal disease?. J Korean Med Sci, 2017, 32(11): 1800-1806.
34. Lee HJ, Son YJ. Prevalence and associated factors of frailty and mortality in patients with end-stage renal disease undergoing hemodialysis: a systematic review and meta-analysis. Int J Environ Res Public Health, 2021, 18(7): 3471.
35. 吴淑琳, 宋洁, 肖萍, 等. 维持性血液透析患者衰弱发生率及影响因素的系统评价. 中华护理教育, 2021, 18(4): 352-357.
36. Nitta K, Hanafusa N, Tsuchiya K. Role of frailty on outcomes of dialysis patients. Contrib Nephrol, 2018, 195: 102-109.
37. Nitta K, Tsuchiya K. Recent advances in the pathophysiology and management of protein-energy wasting in chronic kidney disease. Ren Replace Ther, 2016, 2(1): 1-12.
38. 蔡康琴, 李伟, 王莉, 等. 血液透析患者衰弱现状的调查研究. 护理学杂志, 2019, 34(11): 24-27.
39. 叶丽钦, 周莹, 张海林, 等. 维持性血液透析患者衰弱及其表型对生活质量的影响研究. 中华护理杂志, 2018, 53(9): 1072-1077.
40. Chen LK, Woo J, Assantachai P, et al. Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 2020, 21(3): 300-307.e2.
41. Chen LK, Liu LK, Woo J, et al. Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 2014, 15(2): 95-101.
42. 韩君, 王君俏, 谢博钦, 等. Fried 衰弱表型和 FRAIL 量表及埃德蒙顿衰弱评估量表在社区高龄老年人衰弱筛查中一致性和适用性的比较研究. 中国全科医学, 2021, 24(21): 2669-2675.
43. Ensrud KE, Ewing SK, Cawthon PM, et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc, 2009, 57(3): 492-498.
44. Metsemakers WJ, Morgenstern M, McNally MA, et al. Fracture-related infection: a consensus on definition from an international expert group. Injury, 2018, 49(3): 505-510.
45. 武力, 郑燕蓉, 柴源. 老年住院患者衰弱程度与肌肉减少症严重程度的相关性分析. 现代医学, 2020, 48(5): 647-651.
46. Delgado C, Doyle JW, Johansen KL. Association of frailty with body composition among patients on hemodialysis. J Ren Nutr, 2013, 23(5): 356-362.
47. 宋良晨, 蔡晓燕, 敖强国, 等. 衰弱对老年男性慢性肾脏病患者发生肌少症的影响. 中华老年心脑血管病杂志, 2020, 22(3): 249-252.
48. Gielen E, Beckwée D, Delaere A, et al. Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses. Nutr Rev, 2021, 79(2): 121-147.
49. 翟婉春, 吴树敏, 黄海群. 运动训练对改善维持性血液透析患者衰弱症的研究进展. 中国保健营养, 2021, 31(9): 8-9.
50. 董欣, 莫懿晗, 王秀华, 等. 抗阻运动对老年肌少症危险人群肌肉量、肌力和活动能力的影响. 中国护理管理, 2021, 21(8): 1190-1195.
51. Kirkman DL, Mullins P, Junglee NA, et al. Anabolic exercise in haemodialysis patients: a randomised controlled pilot study. J Cachexia Sarcopenia Muscle, 2014, 5(3): 199-207.
52. Abdala R, Elena Del Valle E, Negri AL, et al. Sarcopenia in hemodialysis patients from Buenos Aires, Argentina. Osteoporos Sarcopenia, 2021, 7(2): 75-80.
53. 孙超, 侯莉明, 简伟明, 等. 我国 60 岁以上老年人群肌少症患病率及相关因素调查. 中华老年医学杂志, 2021, 40(8): 981-986.
54. Stockton KA, Mengersen K, Paratz JD, et al. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int, 2011, 22(3): 859-871.
55. Lin YL, Chen SY, Lai YH, et al. Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients. BMC Nephrol, 2019, 20(1): 54.
56. Rolland Y, Onder G, Morley JE, et al. Current and future pharmacologic treatment of sarcopenia. Clin Geriatr Med, 2011, 27(3): 423-447.

West China Medical Journal

Clinical research progress of sarcopenia and frailty in maintenance hemodialysis patients

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