目的:探讨脑梗死出血转化(HT)的病因,发生率,临床表现和影像学特点及预后。方法:对我院2002年1月至2008年7月96例脑梗死出血转化患者进行回顾性分析。结果:糖尿病、高血压、心房纤颤、血脂异常、大面积脑梗死是HT的主要病因,其发生率为20.3%,第一周为62.5%,第二周为31.2%,两周后为6.3%,其临床表现为头痛、呕吐、肢体无力加重、意识障碍加深,CT或MRI表现为非血肿型与血肿型,死亡率为16.7%。结论:对神经症状及体征加重的患者,尤其是大面积脑死患者,应及早查复查CT或MRI,有利于HT的早期诊治。
Citation:
QING Shaohua,GU Chengwu,HE Hui.. Clinical Analysis of 96 Patients with Hemorrhagic Transformation after Cerebral Infarction. West China Medical Journal, 2009, 24(2): 269-270. doi:
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- 1. Bayramoglu M,Karatas M,Leblebici B,et al.Hemorrhagic transformation in stroke patients[J].Am J Phys Med Rehabil,2003,82(1):48-52..
- 2. Silva Y,Leira R,Tejada J,et al.Molecular signatures of vascular injury are associated with early growth of intracerebral hemorrhage[J].Stroke.2005,36(1):86-91..
- 3. Tong DC,Adami A,Moseley ME,et al.Relationship between apparent diffusion coefficient and subsequent hemorrhagic transformation following acute ischemic stroke[J].Stroke,2000,31(10):2378-2384..
- 4. Kerenyi L,Kardos L,Szasz J,et al.Factors influencing hemorrhagic transformation in ischemic stroke:a clinicopathological comparison[J].Eur J Neurol,2006,13(11):1251-1255..
- 5. 段辽江,齐中华,李胜.出血性脑梗死52例临床分析[J].大连医科大学学报,2007,29(2):151-152..
- 6. Castellanos M,Sobrino T,Millan M,et al.Serum cellular fibronectin and matrix metalloproteinase9 as screening biomarkers for the prediction of parenchymal hematoma after thrombolytic therapy in acute ischemic stroke:a multicenter confirmatory study[J].Stroke.2007,38(6):1855-1859..
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