The Efficacy and Safety of the Combination of Metformin with Glargine in Type 2 Diabetic Subjects_West China Medical Journal

Authors：

HUMaoqing, LUO Yu, YANG Xue, et al.

The Third Affiliated Hospital of Chengdu University of Chinese Traditional Medicine Diabetes Prevention and Cure Center of Sichuan Province, Chengdu 610041, China;

Corresponding author：

Keywords：

甘精胰岛素; 二甲双胍; 2型糖尿病; 疗效; 安全性

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摘要:目的:了解甘精胰岛素联合二甲双胍治疗对口服降糖药血糖控制不理想的2型糖尿病患者的疗效和安全性。方法:对30例口服降糖药血糖控制不理想的2型糖尿病患者给与甘精胰岛素联合二甲双胍治疗,共12周。治疗前后测身高、体重、空腹血糖(FPG)、餐后2小时血糖(PPG)以及糖化血红蛋白(HbA1c)水平。了解治疗期间低血糖发生情况。结果:治疗后的FPG、PPG以及HbA1c水平明显下降,分别下降了303mmol/L、510mmol/L和198%,差异有统计学意义(P lt;005)。治疗后5330%的患者HbA1c水平 lt;70%。治疗前HbA1c水平≥70% lt;90%的患者,治疗后706%的患者HbA1c水平 lt;70%,治疗前HbA1c水平≥90%的患者,治疗后307%的患者HbA1c水平 lt;70%,两者的HbA1c达标率有明显差异(P lt;005)。治疗前后体重及BMI无明显差异(P gt;005)。30例患者中仅发生两次轻微低血糖。结论:甘精胰岛素联合二甲双胍治疗对口服降糖药治疗血糖控制不理想的2型糖尿病患者是安全有效的,尤其是对HbA1c水平 lt;90%的患者,血糖控制更好,达标率更高。

Citation： HU Maoqing,LUO Yu,YANG Xue,et al.. The Efficacy and Safety of the Combination of Metformin with Glargine in Type 2 Diabetic Subjects. West China Medical Journal, 2009, 24(5): 1144-1146. doi: Copy

1.	DAVID M, NATHAN, JOHN B, et al. Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy[J]. Diabetes Care,2008,31(12):111.
2.	叶任高,陆再英.内科学 [M]. 第6版. 北京:北京人民卫生出版社,2004:797814.
3.	LEBOVITZ HE.Treating hyperglycemia in type 2 diabetes: new goals and strategies[J].Cleve Clin J Med, 2002,69(10):809820.
4.	GILLICS PS,FIGGITT DP,LAMB HM. Insulin glargine[J].Drugs,2000,59(2):253260.
5.	GARDER AJ. Metformin: mechanisms of antihyperglycemic action, other pharmacodynamic properties, and safety perspectives[J]. Endocr Pract,1997,3(6):359370.
6.	胡茂清, 吴文莉, 罗玉等.诺和锐30联合二甲双胍治疗30例2型糖尿病患者的临床观察[J].四川医学,2008,29(7):842844.

1. DAVID M, NATHAN, JOHN B, et al. Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy[J]. Diabetes Care,2008,31(12):111.
2. 叶任高,陆再英.内科学 [M]. 第6版. 北京:北京人民卫生出版社,2004:797814.
3. LEBOVITZ HE.Treating hyperglycemia in type 2 diabetes: new goals and strategies[J].Cleve Clin J Med, 2002,69(10):809820.
4. GILLICS PS,FIGGITT DP,LAMB HM. Insulin glargine[J].Drugs,2000,59(2):253260.
5. GARDER AJ. Metformin: mechanisms of antihyperglycemic action, other pharmacodynamic properties, and safety perspectives[J]. Endocr Pract,1997,3(6):359370.
6. 胡茂清, 吴文莉, 罗玉等.诺和锐30联合二甲双胍治疗30例2型糖尿病患者的临床观察[J].四川医学,2008,29(7):842844.

West China Medical Journal

The Efficacy and Safety of the Combination of Metformin with Glargine in Type 2 Diabetic Subjects

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