目的:研究O型RhD阳性孕妇(其丈夫为非O型)血清IgG抗-A(抗-B)抗体效价与新生儿溶血病(HDN)的关系。方法:应用微柱凝胶技术对382例O型RhD阳性孕妇进行了免疫性IgG抗A(B)抗体效价检测及对其新生儿进行HDN(①新生儿ABO、Rh系统定型;②新生儿直抗实验;③游离IgG测定;④放散实验)的检测。结果:382例O型RhD阳性孕妇中IgG抗-A(B)效价 lt;64者330例(占总数86.39%),抗体效价≥64者13.61%。其中发生HDN 5例,抗-A 3例,抗-B12例,总发生率1.31%.结论:夫妇血型不合应及时检测孕妇IgG抗体,随着孕妇体内IgG抗体效价的增高,新生儿ABO溶血病的发病率也随之升高。孕妇产前应定时进行IgG抗体检测,了解效价与新生儿溶血病发病率之问的关系,对于预防新生儿溶血病极为有效。
Citation：
JIANG Jun,XU Ying.. Analysis of the Relationship between the Valence of IgG Antibody In Pregnant Women with Blood Type O and the Rate of Hemolytic Disease in the Newborn. West China Medical Journal, 2009, 24(7): 1761-1763. doi:
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- 1. 万忠和.大剂量静脉注射免疫球蛋白治疗新生儿ABO溶血病18例的疗效观察[J]. 新医学, 2001, 32 (8):480-481.
- 2. DRABIKCLARY K, REDDY V V, BENJAMIN WH, et al. Severe hemolyticdisease of the newborn in a group B AfricanAmerican infant delivered by a group O mother[J]. Ann Clin Lab Sci, 2006, 36 (2):205-207.
- 3. YANG S M, WUQY, LUO H Q, et al. Correlation of newborn hemolytic disease with ABO antibodies in sera of pregnant women[J]. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2005, 13 (5):875-877.
- 4. 高峰.输血与输血技术[M]//刘达庄．免疫血液学,北京:人民卫生出版社, 2003, 99-103.
- 5. 吴定昌,邱月燕,邱小兰,等.微柱凝胶清检测孕妇红细胞血型IgG抗A(B)效价方法的探讨[J]. 中国优生与遗传杂志, 2006, 14 (7):19, 46.
